MS
August 26, 2025
Clinical Sub-Phenotypes of Acute Lung Allograft Dysfunction Associated with Chronic Lung Allograft Dysfunction
Background:Chronic lung allograft dysfunction (CLAD) is the leading cause of mortality after the first year following lung transplantation (LTx). Acute lung allograft dysfunction (ALAD), defined by a ≥10% decline in FEV₁ from baseline best for at least 3 weeks, is a precursor to CLAD. However, only 40% of LTx recipients with ALAD progress to CLAD…
August 12, 2025
Comparison of Three Treatment Regimens for Latent Syphilis of Late or Unknown Duration Using Public Health Surveillance Data
Background: The CDC recommends treating latent syphilis of late/unknown duration (LSUD) with three doses of intramuscular benzathine penicillin G (BPG) or twenty-eight days of oral doxycycline. This recommendation lacks high-quality evidence. Methods: Using public health surveillance data from King County, Washington, we conducted a retrospective cohort study comparing rates of serological cure (>=2-titer RPR decline)…
A study on the association between educational attainment and substance use disorder from ages 33 to 47, and the moderating role of perceived neighborhood social cohesion
A study on the association between educational attainment and substance use disorder from ages 33 to 47, and the moderating role of perceived neighborhood social cohesion. Shawna Hui Chair of the Supervisory Committee:Isaac Rhew Department of Epidemiology & Department of Psychiatry and Behavioral Sciences Purpose: Examine the association between educational attainment at age 27 and…
A Nationwide Analysis of Financial Hardship After Surgery
Background and Objectives: Affordable access to surgical remains elusive for many in the US. However, the financial hardship attributable to surgery is not well understood at the national level. Our objectives were to (1) evaluate the association between surgery and financial hardship among working age adults in the US, (2) compare changes in financial hardship…
Ultra-processed foods, plant and animal source, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study
Background: Ultra processed food (UPF) consumption is associated with adverse health outcomes. Plant- and animal-sourced UPF have a unique nutritional composition to improve palatability which may impact health, but evidence is limited. The objective of this study aimed to investigate the association between UPF intake, plant-, and animal-sourced UPF, and mortality outcomes in older adults….
Elexacaftor/Tezacaftor/Ivacaftor Prescription in Lung Transplant Recipients with Cystic Fibrosis in the US
Elexacaftor/tezacaftor/ivacaftor (ETI) has dramatically improved pulmonary and extrapulmonary manifestations of cystic fibrosis (CF). ETI clinical trials excluded lung transplant (LTx) recipients, and current post-transplant prescribing practices are not evidence-based. We sought to identify the prevalence of new ETI prescriptions among CF LTx recipients in the United States (U.S.) and factors associated with ETI prescription after…
Factors associated with mortality and the need for re-intervention after stage 1 palliation for single ventricle heart disease
Background: Single ventricle management comprises a series of complex surgical procedures that are initiated during the newborn period. Despite advancements in surgical techniques, infants with a single ventricle face high mortality and the likelihood of unplanned reinterventions. Understanding the factors contributing to these reinterventions potentially could enhance patient outcomes, improve preoperative risk counseling to the…
Representation of Minoritized People with Cystic Fibrosis in CF Therapeutics Development Network Clinical Studies
Black and Hispanic people with CF (PwCF) experience a greater burden of worse health outcomes related to pulmonary disease compared to White, non-Hispanic PwCF. Prior evidence suggests that these communities are underrepresented in clinical research in CF. We used clinical study data from four recent modulator studies (CHEC-SC, PROMISE, PROSPECT, and GOAL) as well as…
Cytokines associated with moderate and severe adverse events during a controlled human malaria infection trial
Background: Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events (AEs) have not been examined.Methods: In order to determine which cytokines were associated with moderate and severe AEs, we measured the concentration of…
Metabolite-predicted biological age acceleration and associations with oncologic, neurodegenerative, and adiposity-related endpoints in multi-ancestry populations
Chronologic age is widely understood as a significant risk factor for many chronic diseases and is frequently used in risk stratification to guide selective screening. However, for age-related diseases, chronological age alone may not accurately reflect the underlying heterogeneity in biological aging that contributes to disease risk. Using prospectively collected data from the Women’s Health…
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