MS
December 21, 2023
Prioritizing Out-of-Care Case Investigations in King County, Washington
Health departments need to investigate cases of people with HIV who appear to be out of care but often have insufficient resources to investigate all cases and need a way to prioritize investigations. Methods: In this retrospective cohort analysis, we used classification and regression tree (CART) methodology to develop and validate a decision algorithm for…
Can Artificial Intelligence based Automated CT Brain Interpretation Software help Early Clinical Decision Making for Stroke Patients in Real World Resource Limited Settings with Non-Specialist Physicians? An Interrupted Time Series Study from Tezpur, Assam, India
We evaluated the impact of an AI (Artificial Intelligence) based software for automated interpretation of CT brain through a retrospective interrupted time series study at a rural hospital in Tezpur, India, that is managed by non-specialist physicians and supported by teleradiology services. We compared the diagnostic accuracy of the software to detect an abnormality against…
Hemoptysis and serious outcomes in cystic fibrosis
Hemoptysis is a common and important complication in persons with cystic fibrosis (PwCF). Despite this, there is limited literature on the impact of hemoptysis on contemporary cystic fibrosis (CF) outcomes. We sought to evaluate whether hemoptysis increases risk of lung transplant or death without transplant in PwCF. We reviewed a dataset of PwCF ages 12…
Predictors of Disease Activity in Juvenile Idiopathic Arthritis at 12 and 24 Months After Diagnosis
Identification of characteristics associated with risk of active disease in Juvenile Idiopathic Arthritis (JIA) could inform treatment strategies early in the disease state. This study evaluates JIA disease activity outcomes and patient characteristics associated with active disease at 12- and 24-months post diagnosis from a single large US center. Methods: Disease activity status at 12-…
Association Between Prediagnostic Cigarette Smoking and Colorectal Cancer Survival by Molecular Subtypes and Age-onset Status.
In the United States, colorectal cancer (CRC) remains the third most commonly diagnosed malignancy in both men and women, and approximately 36% of CRC patients die within the first five years after diagnosis. Several factors are known to affect the survival of CRC patients, including smoking history; however, it is unclear whether previously-observed associations between…
December 21, 2022
Heart Rate Variability and Autonomic Function: A Study of Adolescents with Chronic Abdominal Pain and Healthy Adolescents
Background: Chronic abdominal pain is often accompanied by autonomic dysfunction. It is hypothesized that dysregulation of the autonomic nervous system (ANS) results in poorer physiological modulation to physical and psychological stress in the context of persistent pain. Research in adults with chronic pain conditions identified decreased parasympathetic activation using heart rate variability (HRV), as a…
Associations between green space and depressive symptoms in young adults: a longitudinal study
As the number of people living in urban areas rises, it is becoming increasingly important to quantify the relationship between exposure to green space and physical and mental health. Young adulthood in particular is a critical period with profound impacts on health, and often has implications for health outcomes later in life. Our study population…
The association between Adverse Childhood Experiences and HPV vaccination coverage in US young adults: a cross-sectional study
Introduction: Adverse childhood experiences (ACEs) affect more than half of all children in the United States, and people with ACEs are more prone to various unhealthy situations in adulthood. Access to preventive healthcare services, including HPV vaccinations, may help reduce the impact of ACEs on adverse health outcomes. Our objective was to assess the prevalence…
Evaluation of the Safer Use of Antipsychotics in Youth (SUAY) Study on Population Level Antipsychotic Initiation: An Interrupted Time Series Analysis
Background: Atypical antipsychotics carry a high risk profile and may be prescribed for youth with conditions where other first line treatments are more appropriate. This study aimed to evaluate the population-level effectiveness of the Safer Use of Antipsychotics in Youth (SUAY) intervention, which aimed to reduce inappropriate atypical antipsychotic prescribing. Methods: We conducted an interrupted…
Associations of Fatty Liver Disease with Recovery After Traumatic Injury
Fatty liver disease (FLD) is prevalent among US adults (20-30%) and associated with chronic systemic inflammation, extra-hepatic comorbidities, and socioeconomic risk factors for poor health outcomes. These factors may directly and indirectly contribute to an individual’s recovery from traumatic injury. However, FLD has not been studied as a risk factor for poor outcomes in the…
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