MS

December 21, 2022

Heart Rate Variability and Autonomic Function: A Study of Adolescents with Chronic Abdominal Pain and Healthy Adolescents

Background: Chronic abdominal pain is often accompanied by autonomic dysfunction. It is hypothesized that dysregulation of the autonomic nervous system (ANS) results in poorer physiological modulation to physical and psychological stress in the context of persistent pain. Research in adults with chronic pain conditions identified decreased parasympathetic activation using heart rate variability (HRV), as a…

Associations between green space and depressive symptoms in young adults: a longitudinal study

As the number of people living in urban areas rises, it is becoming increasingly important to quantify the relationship between exposure to green space and physical and mental health. Young adulthood in particular is a critical period with profound impacts on health, and often has implications for health outcomes later in life. Our study population…

The association between Adverse Childhood Experiences and HPV vaccination coverage in US young adults: a cross-sectional study

Introduction: Adverse childhood experiences (ACEs) affect more than half of all children in the United States, and people with ACEs are more prone to various unhealthy situations in adulthood. Access to preventive healthcare services, including HPV vaccinations, may help reduce the impact of ACEs on adverse health outcomes. Our objective was to assess the prevalence…

Evaluation of the Safer Use of Antipsychotics in Youth (SUAY) Study on Population Level Antipsychotic Initiation: An Interrupted Time Series Analysis

Background: Atypical antipsychotics carry a high risk profile and may be prescribed for youth with conditions where other first line treatments are more appropriate. This study aimed to evaluate the population-level effectiveness of the Safer Use of Antipsychotics in Youth (SUAY) intervention, which aimed to reduce inappropriate atypical antipsychotic prescribing. Methods: We conducted an interrupted…

Associations of Fatty Liver Disease with Recovery After Traumatic Injury

Fatty liver disease (FLD) is prevalent among US adults (20-30%) and associated with chronic systemic inflammation, extra-hepatic comorbidities, and socioeconomic risk factors for poor health outcomes. These factors may directly and indirectly contribute to an individual’s recovery from traumatic injury. However, FLD has not been studied as a risk factor for poor outcomes in the…

Diet Quality and Kidney Outcomes in Adolescent and Adult American Indians: The Strong Heart Family Study

Background: The burden of chronic and end stage kidney disease (CKD and ESKD) is exceedingly high amongst American Indians (AI). We sought to examine the relationship of diet quality, a modifiable risk factor, and kidney outcomes in AI adolescents and young adults, hypothesizing that healthier diets are associated with lower odds of incident albuminuria and…

Development of CPAP Dose Response for Patients with Obstructive Sleep Apnea: Secondary Analysis

Background: First-line treatment for obstructive sleep apnea (OSA) is continuous positive airway pressure therapy (CPAP). Although CPAP is efficacious, the definition of adequate use (effectiveness) is known to be arbitrary. We aimed to characterize a CPAP dose response for short term outcomes, including sleepiness severity and quality of life. Methods We performed secondary analysis on…

Left atrial strain and the risk of arrhythmias on extended ambulatory cardiac monitoring: the Multi-Ethnic Study of Atherosclerosis

Background: Abnormalities in left atrial (LA) function can be identified before the development of overt LA structural changes. Little is known about the relationship between LA function and the risk of subclinical atrial and ventricular arrhythmias.Methods: 1,441 participants of the Multi-Ethnic Study of Atherosclerosis completed speckle-tracking echocardiography and cardiac monitoring during 2016-2018 (mean age 73…

Association of media and messaging on the impact of the Seattle sugar-sweetened beverage tax

Consumption of sugar-sweetened beverages (SSB) has been linked with poor health outcomes such as Type 2 Diabetes, cardiovascular disease, metabolic syndrome, and obesity. Public health and policy experts have been increasingly turning to fiscal policy as a potential strategy to lower consumption of excess sugar from SSBs. However, there is evidence that the public acceptance…

The association of dietary factors and bacterial alpha diversity in the colorectal tumor-associated microbiome

Background: Aspects of the gut microbiome, such as microbial diversity, are related to the development and prognosis of colorectal cancer (CRC). Diet has been linked to the gut microbiome but no studies have considered the association of diet and microbial diversity in the tumor-associated microbiome. The goal of this study was to determine if dietary…