MS

April 5, 2024

Another Person

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March 13, 2024

Emergency Department Utilization and Unplanned Hospitalizations Associated with Floods in the US from 2008-2017: An Interrupted Time Series and Cohort Analysis

Flooding is a major environmental hazard, with events increasing in intensity and frequency in the context of anthropogenic climate change. Significant health and economic impacts result from floods, particularly among vulnerable populations. However, comprehensive analyses of the health consequences of flooding, especially in terms of healthcare utilization and associated costs in the United States, remain…

Phase 2 randomized open label adaptive platform clinical trial of the clinical and biological effects of IC14 treatment in patients with severe COVID-19

In I-SPY COVID, a Phase 2 randomized open label adaptive platform clinical trial, we examined the clinical efficacy of the anti-CD14 monoclonal antibody IC14 for patients with severe COVID-19 requiring high-level respiratory support. As detailed in the initial report of the first seven investigational agents, IC14 treatment did not satisfy the Bayesian criteria for a…

Incidence and Outcomes of Late-Onset Right Ventricular Failure in Patients with Left Ventricular Assist Device

Right Ventricular Failure (RVF) is an incompletely understood complication observed in patients undergoing durable left ventricular assist device (LVAD) implantation. Prior research has primarily concentrated on early post-implantation RVF. This study seeks to characterize the incidence and clinical features associated with late-onset RVF in LVAD patients. Methods: This retrospective cohort study included individuals undergoing LVAD…

February 1, 2024

Robert Smith

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December 26, 2023

Changes in vaginal bacteria and inflammatory mediators from periconception through early-postpartum in a cohort of HIV-negative Kenyan women

Women’s increased risk of HIV acquisition during pregnancy and the postpartum period maybe mediated by changes in vaginal microbiota and/or cytokines. Methods: A cohort of HIV-1-seronegative Kenyan women contributed vaginal fluid samples at six pregnancy time points: periconception, positive pregnancy test, first trimester, second trimester, third trimester and postpartum. Concentrations of vaginal bacteria previously associated…

Examining the Interplay of Social Support, Depression, and Blood Pressure: The Strong Heart Family Study

Compared to the general US population, American Indian (AI) adults have disproportionately higher rates of mental health symptoms, including depression. In 2019, over 18% (n=260,000) of surveyed American Indians/Alaska Natives (AI/AN) 18 years of age or older experienced mental illness during the past year. Several cross-sectional studies have also shown that depression is common in…

Sexual Orientation and Influenza Vaccine Uptake in the Southern United States

Research at the national level suggests that gay or lesbian adults are significantly more likely to receive a flu vaccine compared to straight individuals, however, this relationship has not been explored at the regional level. The American South is known for its health disparities, high level of poverty, and social conservatism, which may impact the…

Associations Between Structural and Social Determinants of Health with Pediatric Surgical Site Infections

Determine if disparities exist in surgical site infections (SSI) for pediatric patients from minoritized language and racial and ethnic groups, and for those with a public insurance payor. Design, Setting, and Participants: This single-center cohort study retrospectively examined outcomes of patients undergoing eligible inpatient and outpatient surgical procedures from October 1, 2015 to September 30,…

Predictors of Mortality and Discharge Location for Patients Supported by Venoarterial Extracorporeal Membrane Oxygenation

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a form of advanced life support that is increasingly used to treat cardiac or pulmonary failure, however morbidity and mortality for patients supported by VA-ECMO remains high. Elucidation of predictors of mortality and discharge location for survivors may aid clinicians, patients, and families in prognostication for patients supported by…