Graduate
November 24, 2020
Early Management of Community-Acquired Sepsis in a Regional Thai Referral Hospital: a Prospective Observational Study
PURPOSE The epidemiology and management of sepsis is poorly characterized in low- and middle-income countries. METHODS We performed a prospective observational cohort study of adults with community-acquired sepsis in a 1,420-bed regional referral hospital in northeast Thailand. Sepsis was defined as suspected infection plus organ dysfunction. RESULTS Between March 2013 and February 2014, 932 patients…
Evaluation of an mHealth SMS dialogue strategy to meet women’s and couples’ postpartum contraceptive needs in Kenya (Mobile WACh XY): A randomized controlled trial
OBJECTIVE To evaluate the effect of a two-way SMS intervention on postpartum contraceptive use among individual women and couple dyads. METHODS Mobile WACh XY was an unblinded randomized controlled trial conducted in two public county hospitals in western Kenya. Pregnant, HIV-negative women at least 14 years of age with estimated gestational age ≥28 weeks who…
The Mutational Landscape of Recurrent vs Non-Recurrent Human Papillomavirus-Associated Oropharyngeal Cancer
Current therapies are effective for a subset of human papillomavirus (HPV)-associated head and neck cancers (HNC), although up to a quarter of these cases fail treatment. Identification of genomic alterations associated with therapeutic response or lack thereof from the outset of treatment would have substantial clinical implications. We hypothesized that HPV-related oropharyngeal squamous cell carcinoma…
Overcoming Barriers to HIV/STD Partner Services in Kenya and the United States
Increasing the proportion of people living with HIV and sexually transmitted diseases (STDs) who know their status is critical to curbing the HIV and STD epidemics. Partner services (PS) are a core public health strategy that test and treat or link to care the partners of individuals newly diagnosed with HIV or an STD (“index…
Subclinical tuberculosis among HIV-infected adults: Clinical features and outcomes in a South African cohort
OBJECTIVE Describe the prevalence, clinical characteristics, and mortality risk for HIV-infected adults with subclinical tuberculosis. DESIGN Untreated HIV-infected adults presenting for outpatient care in Durban, South Africa were screened for tuberculosis-related symptoms and had sputum tested by acid-fast bacilli smear and tuberculosis culture. Active tuberculosis and subclinical tuberculosis were defined as having any tuberculosis symptom…
Cardiovascular Risk Factors and Memory Function in Nepal: Findings from the Dhulikhel Heart Study
BACKGROUND Although a growing number of studies are focusing their attention on cognitive domains, fewer studies have been conducted in developing countries. Previous studies have suggested that cardiovascular disease (CVD) risk factors may be related to cognitive health or impairment. In the present study, we assessed the associations of CVD risk factors with short-term memory…
Analysis of types of Tumor-Infiltrating Immune Cells in Oral Squamous Cell Carcinoma (OSCC) and their associations with survival of OSCC patients
BACKGROUND The 5-year survival associated with oral cancer (OSCC) is relatively low. Recent investigations have implicated the presence of tumor infiltrating lymphocytes (TILs) as independent prognostic markers in several malignancies, including oral cancer. However, the studies of oral cancer evaluated only a limited number of immune cell types as prognostic markers. CIBERSORT, a computational software…
Exploring Factors Associated with the Prioritization of South-to-South Partnerships by International Global Health Institutions in the Southern Hemisphere
INTRODUCTION Academic global health programs in North America have proliferated substantially since the turn of the century. Recent studies have sought to better understand the sustainability and impact of these programs and to evaluate the extent to which partnerships between global health academic institutions in North America and international institutions were mutually developed and are…
Evaluation of Zika Virus Testing Through the Washington State Department of Health
OBJECTIVES We used Washington State Department of Health (DOH) Zika surveillance data from January 1 to October 31, 2016 to (1) describe the population of individuals for whom Zika testing was requested, (2) determine whether health care provider (HCP) disciplines differ in appropriate referral practices for Zika testing, and (3) determine whether HCP disciplines differ…
The impact of HIV infection on cervical cancer presentation and survival in Uganda
OBJECTIVES To determine how HIV infection impacts cervical cancer stage and overall survival (OS) among Ugandan women. METHODS/MATERIALS Women diagnosed with cervical cancer were followed between 2013 and 2015 at the Uganda Cancer Institute (UCI). A Poisson regression model was fit to calculate prevalence ratios (PR) for the association between HIV infection and late stage…
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