Faculty

Ulrike Peters

Research Professor, Epidemiology

206-667-2450
upeters@fredhutch.org

Education

PhD Nutrition, University of Kiel (Germany), 1998
MPH Epidemiology, University of North Carolina, 1999

Contact

206-667-2450
upeters@fredhutch.org

Fred Hutchinson Cancer Research Center
Box 358080
1100 Fairview Ave N,M4-B402
PO Box 1024
Seattle, WA 98109

Research Interests

My research interest centers on the genetic and molecular epidemiology of common complex diseases, including cancer, obesity, type 2 diabetes, and cardiovascular diseases, as well as intermediate traits, including inflammation and metabolic measurements. Within well characterized and diverse study populations, we are studying the impact of common and rare genetic variants across the entire genome, as well as interactions between genetic variants and environmental factors (such as diet, exercise, smoking and aspirin use). We are increasingly bringing in functional genomic data to inform gene-environment interactions as well as rare variant testing. In addition, we are conducting a large-scale study to integrate the tumor and host genome to investigate associations of germline genetic, environmental risk factors and survival in relation to colorectal cancer subtypes defined by existing tumor characteristics as well as novel somatic mutations in colorectal cancer. A further interest of us is the translation of our findings into public health practice and clinical care. Accordingly, we have developed comprehensive risk prediction models that can personalize screening decisions.

Recent Publications (PubMed)

Leisure time sedentary behaviour and risks of breast, colorectal, and prostate cancer: A Mendelian randomization analysis.
(2023 Mar 22)
medRxiv
Papadimitriou N, Kazmi N, Dimou N, Tsilidis KK, Martin RM, Lewis SJ, Lynch BM, Hoffmeister M, Kweon SS, Li L, Milne RL, Sakoda LC, Schoen RE, Phipps AI, Figueiredo JC, Peters U, Dixon-Suen SC, Gunter MJ, Murphy N

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.
(2023 Mar 20)
Nat Genet
Hou K, Ding Y, Xu Z, Wu Y, Bhattacharya A, Mester R, Belbin GM, Buyske S, Conti DV, Darst BF, Fornage M, Gignoux C, Guo X, Haiman C, Kenny EE, Kim M, Kooperberg C, Lange L, Manichaikul A, North KE, Peters U, Rasmussen-Torvik LJ, Rich SS, Rotter JI, Wheeler HE, Wojcik GL, Zhou Y, Sankararaman S, Pasaniuc B

Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer.
(2023 Mar 21)
Cell Rep Med 4(3): 100974
Du M, Gu D, Xin J, Peters U, Song M, Cai G, Li S, Ben S, Meng Y, Chu H, Chen L, Wang Q, Zhu L, Fu Z, Zhang Z, Wang M

Risk-stratified screening for colorectal cancer using genetic and environmental risk factors: A cost-effectiveness analysis based on real-world data.
(2023 Mar 9)
Clin Gastroenterol Hepatol
van den Puttelaar R, Meester RGS, Peterse EEP, Zauber AG, Zheng J, Hayes RB, Su YR, Lee JK, Thomas M, Sakoda LC, Li Y, Corley DA, Peters U, Hsu L, Lansdorp-Vogelaar I

Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity.
(2023 Jan 19)
medRxiv
Thomas M, Su YR, Rosenthal EA, Sakoda LC, Schmit SL, Timofeeva MN, Chen Z, Fernandez-Rozadilla C, Law PJ, Murphy N, Carreras-Torres R, Diez-Obrero V, van Duijnhoven FJ, Jiang S, Shin A, Wolk A, Phipps AI, Burnett-Hartman A, Gsur A, Chan AT, Zauber AG, Wu AH, Lindblom A, Um CY, Tangen CM, Gignoux C, Newton C, Haiman CA, Qu C, Bishop DT, Buchanan DD, Crosslin DR, Conti DV, Kim DH, Hauser E, White E, Siegel E, Schumacher FR, Rennert G, Giles GG, Hampel H, Brenner H, Oze I, Oh JH, Lee JK, Schneider JL, Chang-Claude J, Kim J, Huyghe JR, Zheng J, Hampe J, Greenson J, Hopper JL, Palmer JR, Visvanathan K, Matsuo K, Matsuda K, Jung KJ, Li L, Marchand LL, Vodickova L, Bujanda L, Gunter MJ, Matejcic M, Jenkins MA, Slattery ML, D'Amato M, Wang M, Hoffmeister M, Woods MO, Kim M, Song M, Iwasaki M, Du M, Udaltsova N, Sawada N, Vodicka P, Campbell PT, Newcomb PA, Cai Q, Pearlman R, Pai RK, Schoen RE, Steinfelder RS, Haile RW, Vandenputtelaar R, Prentice RL, Küry S, Castellví-Bel S, Tsugane S, Berndt SI, Lee SC, Brezina S, Weinstein SJ, Chanock SJ, Jee SH, Kweon SS, Vadaparampil S, Harrison TA, Yamaji T, Keku TO, Vymetalkova V, Arndt V, Jia WH, Shu XO, Lin Y, Ahn YO, Stadler ZK, Van Guelpen B, Ulrich CM, Platz EA, Potter JD, Li CI, Meester R, Moreno V, Figueiredo JC, Casey G, Vogelaar IL, Dunlop MG, Gruber SB, Hayes RB, Pharoah PDP, Houlston RS, Jarvik GP, Tomlinson IP, Zheng W, Corley DA, Peters U, Hsu L

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