Faculty

Holly R Harris

Affiliate Associate Professor, Epidemiology

206-667-2712

Education

ScD Harvard T.H. Chan,
MPH University of Southern California, 2005
BA Macalester College, 2000

Contact

206-667-2712

Fred Hutchinson Cancer Research Center
Box M4-B859
Program in Epidemiology, Division of Public Health Sciences
1100 Fairview Avenue North
Seattle, WA 98109

Research Interests

I am broadly interested in the impact of lifestyle, nutrition, and genetic factors on women’s health. Specifically, I have focused on ovarian and breast cancer, as well as on hormonally related conditions that have shared reproductive risk factors with these diseases, including endometriosis and uterine fibroids. Much of my research to date has focused on understanding the role of the potentially modifiable risk factors of diet and lifestyle on the risk of these conditions. A more recent facet of my research is to explore the interrelatedness of these conditions and their shared risk factors. As ovarian cancer is rare, I am particularly interested in identifying women, such as those with endometriosis, who may be at higher risk because these women may benefit from screening modalities for ovarian cancer which are currently not appropriate for population-based use. Identification of women at high risk for ovarian cancer and breast cancer is also important as it allows for targeted prevention strategies and can guide clinical decisions regarding frequency of screening and chemoprevention strategies for both of these cancers. Finally, understanding the influence of genetic factors, both alone or as a part of gene-environment interactions may facilitate prevention and help identify women most at risk for ovarian and breast cancer.

Recent Publications (PubMed)

Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it?
(2023)
Front Reprod Health 5(): 1297907
Yousif A, DePari M, Vitonis AF, Harris HR, Shafrir AL, Terry KL, Missmer SA, Sasamoto N

Concurrent RB1 loss and BRCA-deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.
(2023 Nov 10)
medRxiv
Saner FAM, Takahashi K, Budden T, Pandey A, Ariyaratne D, Zwimpfer TA, Meagher NS, Fereday S, Twomey L, Pishas KI, Hoang T, Bolithon A, Traficante N, Alsop K, Christie EL, Kang EY, Nelson GS, Ghatage P, Lee CH, Riggan MJ, Alsop J, Beckmann MW, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, El-Bahrawy MA, Elishaev E, Erber R, Gayther SA, Gentry-Maharaj A, Blake Gilks C, Harnett PR, Harris HR, Hartmann A, Hein A, Hendley J, AOCS Group, Hernandez BY, Jakubowska A, Jimenez-Linan M, Jones ME, Kaufmann SH, Kennedy CJ, Kluz T, Koziak JM, Kristjansdottir B, Le ND, Lener M, Lester J, Lubiński J, Mateoiu C, Orsulic S, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Rinda Soong T, Steed H, Sukumvanich P, Talhouk A, Taylor SE, Vierkant RA, Wang C, Widschwendter M, Wilkens LR, Winham SJ, Anglesio MS, Berchuck A, Brenton JD, Campbell I, Cook LS, Doherty JA, Fasching PA, Fortner RT, Goodman MT, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Menon U, Modugno F, Pharoah PDP, Schildkraut JM, Sundfeldt K, Swerdlow AJ, Goode EL, DeFazio A, Köbel M, Ramus SJ, Bowtell DDL, Garsed DW

Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium.
(2023 Dec)
Br J Cancer 129(12): 1956-1967
Petrick JL, Joslin CE, Johnson CE, Camacho TF, Peres LC, Bandera EV, Barnard ME, Beeghly A, Bethea TN, Dempsey LF, Guertin K, Harris HR, Moorman PG, Myers ER, Ochs-Balcom HM, Rosenow W, Setiawan VW, Wu AH, Schildkraut JM, Rosenberg L

A framework for assessing interactions for risk stratification models: the example of ovarian cancer.
(2023 Nov 8)
J Natl Cancer Inst 115(11): 1420-1426
Phung MT, Lee AW, McLean K, Anton-Culver H, Bandera EV, Carney ME, Chang-Claude J, Cramer DW, Doherty JA, Fortner RT, Goodman MT, Harris HR, Jensen A, Modugno F, Moysich KB, Pharoah PDP, Qin B, Terry KL, Titus LJ, Webb PM, Wu AH, Zeinomar N, Ziogas A, Berchuck A, Cho KR, Hanley GE, Meza R, Mukherjee B, Pike MC, Pearce CL, Trabert B

Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case-Control Study from the Ovarian Cancer Association Consortium.
(2023 Aug 1)
Cancer Epidemiol Biomarkers Prev 32(8): 1087-1096
Gersekowski K, Ibiebele TI, Australian Ovarian Cancer Study Group, Doherty JA, Harris HR, Goodman MT, Terry KL, Wu AH, Bandera EV, Qin B, Ong JS, Tyrer JP, Dixon-Suen SC, Modugno F, Risch HA, Webb PM

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