Faculty

Mandy Fretts

Associate Professor, Epidemiology

206-543-9236

Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact

206-543-9236

Cardiovascular Health Research Unit
Box 357236
1730 Minor Ave, Suite 1360
Seattle, WA 98101
University of Washington
Office F-250B
Box 357236
Department of Epidemiology
Seattle, WA 98195

Bio

I am most interested in observational and interventional research aimed at improving the cardio-metabolic health of American Indians. I have been actively involved with the Strong Heart Study, a longitudinal study of cardiovascular disease and its risk factors in 13 American Indian communities, for the past twelve years. My research efforts primarily focus on the association of physical activity, diet, a healthy lifestyle, or gene*diet interactions with diabetes-related phenotypes. I am also currently working on developing a culturally-appropriate diet intervention to promote diabetes control among American Indians.

In addition to my work with the Strong Heart Study, I am also actively involved in several on-going projects related to fatty acids, diet, diet*gene interactions, and cardiovascular outcomes in the Cardiovascular Health Study and the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology).

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Subclinical atherosclerosis in adolescents and young adults and the risk of cardiovascular disease: The Strong Heart Family Study (SHFS).
(2022 May 10)
Nutr Metab Cardiovasc Dis
Reese JA, Roman MJ, Deen JF, Ali T, Cole SA, Devereux RB, Fretts AM, Howard BV, Lee ET, Malloy K, Singh P, Umans JG, Zhang Y

Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults.
(2022 May 2)
JAMA Netw Open 5(5): e2213242
Fretts AM, Hazen SL, Jensen P, Budoff M, Sitlani CM, Wang M, de Oliveira Otto MC, DiDonato JA, Lee Y, Psaty BM, Siscovick DS, Sotoodehnia N, Tang WHW, Lai H, Lemaitre RN, Mozaffarian D

Associations of Dietary Intake with Urinary Melamine and Derivative Concentrations among Children in the GAPPS Cohort.
(2022 Apr 19)
Int J Environ Res Public Health 19(9):
Melough MM, Day DB, Fretts AM, Wang S, Flynn JT, de Boer IH, Zhu H, Kannan K, Sathyanarayana S

High Level of Selenium Exposure in the Strong Heart Study: A Cause for Incident Cardiovascular Disease?
(2022 Jun 7)
Antioxid Redox Signal
Zhao D, Domingo-Relloso A, Tellez-Plaza M, Nigra AE, Valeri L, Moon KA, Goessler W, Best LG, Ali T, Umans JG, Fretts A, Cole SA, Navas-Acien A

Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design.
(2022 Jun 27)
Am J Epidemiol 191(7): 1153-1173
Oelsner EC, Krishnaswamy A, Balte PP, Allen NB, Ali T, Anugu P, Andrews HF, Arora K, Asaro A, Barr RG, Bertoni AG, Bon J, Boyle R, Chang AA, Chen G, Coady S, Cole SA, Coresh J, Cornell E, Correa A, Couper D, Cushman M, Demmer RT, Elkind MSV, Folsom AR, Fretts AM, Gabriel KP, Gallo LC, Gutierrez J, Han MLK, Henderson JM, Howard VJ, Isasi CR, Jacobs DR Jr, Judd SE, Mukaz DK, Kanaya AM, Kandula NR, Kaplan RC, Kinney GL, Kucharska-Newton A, Lee JS, Lewis CE, Levine DA, Levitan EB, Levy BD, Make BJ, Malloy K, Manly JJ, Mendoza-Puccini C, Meyer KA, Min YN, Moll MR, Moore WC, Mauger D, Ortega VE, Palta P, Parker MM, Phipatanakul W, Post WS, Postow L, Psaty BM, Regan EA, Ring K, Roger VL, Rotter JI, Rundek T, Sacco RL, Schembri M, Schwartz DA, Seshadri S, Shikany JM, Sims M, Hinckley Stukovsky KD, Talavera GA, Tracy RP, Umans JG, Vasan RS, Watson KE, Wenzel SE, Winters K, Woodruff PG, Xanthakis V, Zhang Y, Zhang Y, for the C4R Investigators.

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