Mandy Fretts

Associate Professor, Epidemiology



PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007



Cardiovascular Health Research Unit
Box 357236
1730 Minor Ave, Suite 1360
Seattle, WA 98101
University of Washington
Office F-250B
Box 357236
Department of Epidemiology
Seattle, WA 98195


I am most interested in observational and interventional research aimed at improving the cardio-metabolic health of American Indians. I have been actively involved with the Strong Heart Study, a longitudinal study of cardiovascular disease and its risk factors in 13 American Indian communities, for the past twelve years. My research efforts primarily focus on the association of physical activity, diet, a healthy lifestyle, or gene*diet interactions with diabetes-related phenotypes. I am also currently working on developing a culturally-appropriate diet intervention to promote diabetes control among American Indians.

In addition to my work with the Strong Heart Study, I am also actively involved in several on-going projects related to fatty acids, diet, diet*gene interactions, and cardiovascular outcomes in the Cardiovascular Health Study and the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology).

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.
(2021 Jan 14)
HGG Adv 2(1):
Sun D, Richard M, Musani SK, Sung YJ, Winkler TW, Schwander K, Chai JF, Guo X, Kilpeläinen TO, Vojinovic D, Aschard H, Bartz TM, Bielak LF, Brown MR, Chitrala K, Hartwig FP, Horimoto ARVR, Liu Y, Manning AK, Noordam R, Smith AV, Harris SE, Kühnel B, Lyytikäinen LP, Nolte IM, Rauramaa R, van der Most PJ, Wang R, Ware EB, Weiss S, Wen W, Yanek LR, Arking DE, Arnett DK, Barac A, Boerwinkle E, Broeckel U, Chakravarti A, Chen YI, Cupples LA, Davigulus ML, de Las Fuentes L, de Mutsert R, de Vries PS, Delaney JAC, Roux AVD, Dörr M, Faul JD, Fretts AM, Gallo LC, Grabe HJ, Gu CC, Harris TB, Hartman CCA, Heikkinen S, Ikram MA, Isasi C, Johnson WC, Jonas JB, Kaplan RC, Komulainen P, Krieger JE, Levy D, Lifelines Cohort Study., Liu J, Lohman K, Luik AI, Martin LW, Meitinger T, Milaneschi Y, O'Connell JR, Palmas WR, Peters A, Peyser PA, Pulkki-Råback L, Raffel LJ, Reiner AP, Rice K, Robinson JG, Rosendaal FR, Schmidt CO, Schreiner PJ, Schwettmann L, Shikany JM, Shu XO, Sidney S, Sims M, Smith JA, Sotoodehnia N, Strauch K, Tai ES, Taylor K, Uitterlinden AG, van Duijn CM, Waldenberger M, Wee HL, Wei WB, Wilson G, Xuan D, Yao J, Zeng D, Zhao W, Zhu X, Zonderman AB, Becker DM, Deary IJ, Gieger C, Lakka TA, Lehtimäki T, North KE, Oldehinkel AJ, Penninx BWJH, Snieder H, Wang YX, Weir DR, Zheng W, Evans MK, Gauderman WJ, Gudnason V, Horta BL, Liu CT, Mook-Kanamori DO, Morrison AC, Pereira AC, Psaty BM, Amin N, Fox ER, Kooperberg C, Sim X, Bierut L, Rotter JI, Kardia SLR, Franceschini N, Rao DC, Fornage M

Longitudinal Plasma Lipidome and Risk of Type 2 Diabetes in a Large Sample of American Indians With Normal Fasting Glucose: The Strong Heart Family Study.
(2021 Dec)
Diabetes Care 44(12): 2664-2672
Miao G, Zhang Y, Huo Z, Zeng W, Zhu J, Umans JG, Wohlgemuth G, Pedrosa D, DeFelice B, Cole SA, Fretts AM, Lee ET, Howard BV, Fiehn O, Zhao J

Circulating Ceramides and Sphingomyelins and Risk of Mortality: The Cardiovascular Health Study.
(2021 Nov 26)
Clin Chem 67(12): 1650-1659
Fretts AM, Jensen PN, Hoofnagle AN, McKnight B, Sitlani CM, Siscovick DS, King IB, Psaty BM, Sotoodehnia N, Lemaitre RN

Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes.
J Lipid Res 62(): 100119
Fretts AM, Jensen PN, Hoofnagle AN, McKnight B, Howard BV, Umans J, Sitlani CM, Siscovick DS, King IB, Djousse L, Sotoodehnia N, Lemaitre RN

Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study.
(2021 Aug 2)
JAMA Netw Open 4(8): e2122844
Lemaitre RN, Jensen PN, Wang Z, Fretts AM, McKnight B, Nemet I, Biggs ML, Sotoodehnia N, de Oliveira Otto MC, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D

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