Faculty

Mandy Fretts

Associate Professor, Epidemiology


Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact


University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Risk Reclassification Beyond BMI by Waist Circumference and Waist-to-Hip Ratio Across 9 Cardiovascular Outcomes: Results From the Cross-Cohort Collaboration.
(2026 Aug 11)
J Am Coll Cardiol 88(6): 670-684
Dardari ZA, Yao Z, Zhang J, Bakoyannis G, Nan H, Staten LK, Jha KK, Tasdighi E, Jelwan Y, Burka S, Matsushita K, Lima JAC, Psaty BM, Fretts AM, Lemaitre RN, Cohen DL, Appel LJ, Khera A, Shah AM, Hall ME, Judd SE, Safford MM, Cole SA, Vasan RS, Benjamin EJ, Cawthon PM, Orwoll E, LaMonte MJ, Eaton CB, El Khoudary SR, Jackson EA, Janssen I, Lotufo PA, Bensenor IM, Bittencourt MS, Bhatt AS, Ricardo AC, Blaha MJ

Adherence to the American Heart Association's Life's Essential 8 Is Associated With Reduced Odds of Albuminuria Among American Indian Individuals in the Strong Heart Family Study.
(2026 Aug 4)
J Am Heart Assoc 15(15): e041495
Mokiao RH, Carlin K, Deen JF, Umans JG, Young BA, Fretts AM

Lithium exposure in areas of the Western United States: Water and urinary levels in the Strong Heart Family Study.
(2026 Jul 23)
J Expo Sci Environ Epidemiol
Bannon EB, Lieberman-Cribbin W, Basu A, Mitra A, Izuchukwu C, Ross J, Azad S, Collado W, Kupsco A, Domingo Relloso A, Goldsmith J, Umans JG, Zhang Y, Ali T, Fretts AM, Zacher T, O'Leary R, O'Leary M, Bostick BC, Chillrud SN, Navas-Acien A, Nigra AE, Schilling K

Associations of drinking water and urinary uranium with incident diabetes among U.S. adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Family Study.
(2026 Sep 15)
Environ Res 306(Pt 3): 125295
Spaur M, Schilling K, Glabonjat RA, Basu A, Patterson KP, Lieberman-Cribbin W, Chen Q, Ravalli F, Galvez-Fernandez M, Factor-Litvak P, Chillrud S, Bostick BC, O'Leary R, O'Leary M, Zacher T, Zhang Y, Fretts AM, Umans JG, Barr RG, Shea SJ, Navas-Acien A, Nigra AE

Recruitment strategies for a randomized controlled trial in a rural American Indian community: the Cooking for Health Study.
(2026 Jun 27)
Trials
Green SA, O'Leary R, Huber CM, Thorndike AN, Best LG, Brown MC, O'Leary M, Umans J, Hager A, Whitebull R, Beresford S, Fretts AM

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