Mandy Fretts

Associate Professor, Epidemiology



PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007



University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195


Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

The social drivers of health for Native Hawaiian and Pacific Islander youth in the United States.
(2024 Mar)
Prev Med Rep 39(): 102658
Mokiao RH, Carlin K, Spencer MS, Young BA, Fretts AM

Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
(2024 Mar)
Hypertension 81(3): 552-560
Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM, Morrison AC, Bartz TM, Fretts AM, Guo X, Lemaitre RN, Liu CT, Noordam R, de Mutsert R, Rosendaal FR, Wang CA, Beilin LJ, Mori TA, Oddy WH, Pennell CE, Chai JF, Whitton C, van Dam RM, Liu J, Tai ES, Sim X, Neuhouser ML, Kooperberg C, Tinker LF, Franceschini N, Huan T, Winkler TW, Bentley AR, Gauderman WJ, Heerkens L, Tanaka T, van Rooij J, Munroe PB, Warren HR, Voortman T, Chen H, Rao DC, Levy D, Ma J, CHARGE Gene-Lifestyle Interactions Working Group

Associations of plasma sphingolipids with measures of insulin sensitivity, β-cell function, and incident diabetes in Japanese Americans.
(2023 Oct 29)
Nutr Metab Cardiovasc Dis
Bae JC, Wander PL, Lemaitre RN, Fretts AM, Sitlani CM, Bui HH, Thomas MK, Leonetti D, Fujimoto WY, Boyko EJ, Utzschneider KM

Plasma lipidomic markers of diet quality are associated with incident coronary heart disease in American Indian adults: the Strong Heart Family Study.
(2023 Dec 30)
Am J Clin Nutr
Wen X, Fretts AM, Miao G, Malloy KM, Zhang Y, Umans JG, Cole SA, Best LG, Fiehn O, Zhao J

Dietary magnesium, C-reactive protein and interleukin-6: The Strong Heart Family Study.
PLoS One 18(12): e0296238
Rao ND, Lemaitre RN, Sitlani CM, Umans JG, Haack K, Handeland V, Navas-Acien A, Cole SA, Best LG, Fretts AM

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