Faculty

Mandy Fretts

Associate Professor, Epidemiology

206-543-9236

Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact

206-543-9236

Cardiovascular Health Research Unit
Box 357236
1730 Minor Ave, Suite 1360
Seattle, WA 98101
University of Washington
Office F-250B
Box 357236
Department of Epidemiology
Seattle, WA 98195

Bio

I am most interested in observational and interventional research aimed at improving the cardio-metabolic health of American Indians. I have been actively involved with the Strong Heart Study, a longitudinal study of cardiovascular disease and its risk factors in 13 American Indian communities, for the past twelve years. My research efforts primarily focus on the association of physical activity, diet, a healthy lifestyle, or gene*diet interactions with diabetes-related phenotypes. I am also currently working on developing a culturally-appropriate diet intervention to promote diabetes control among American Indians.

In addition to my work with the Strong Heart Study, I am also actively involved in several on-going projects related to fatty acids, diet, diet*gene interactions, and cardiovascular outcomes in the Cardiovascular Health Study and the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology).

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Plasma Ceramides containing Saturated Fatty Acids are Associated with Risk of Type 2 Diabetes.
(2021 Sep 20)
J Lipid Res
Fretts AM, Jensen PN, Hoofnagle AN, McKnight B, Howard BV, Umans J, Sitlani CM, Siscovick DS, King IB, Djousse L, Sotoodehnia N, Lemaitre RN

Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study.
(2021 Aug 2)
JAMA Netw Open 4(8): e2122844
Lemaitre RN, Jensen PN, Wang Z, Fretts AM, McKnight B, Nemet I, Biggs ML, Sotoodehnia N, de Oliveira Otto MC, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D

Longitudinal Plasma Measures of Trimethylamine N-Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community-Based Older Adults.
(2021 Sep 7)
J Am Heart Assoc 10(17): e020646
Lee Y, Nemet I, Wang Z, Lai HTM, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Sotoodehnia N, Budoff M, DiDonato JA, McKnight B, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D

Assessment of Plasma Phospholipid Very-Long-Chain Saturated Fatty Acid Levels and Healthy Aging.
(2021 Aug 2)
JAMA Netw Open 4(8): e2120616
Bockus LB, Biggs ML, Lai HTM, de Olivera Otto MC, Fretts AM, McKnight B, Sotoodehnia N, King IB, Song X, Siscovick DS, Mozaffarian D, Lemaitre RN

Blood DNA Methylation and Incident Coronary Heart Disease: Evidence From the Strong Heart Study.
(2021 Aug 4)
JAMA Cardiol
Navas-Acien A, Domingo-Relloso A, Subedi P, Riffo-Campos AL, Xia R, Gomez L, Haack K, Goldsmith J, Howard BV, Best LG, Devereux R, Tauqeer A, Zhang Y, Fretts AM, Pichler G, Levy D, Vasan RS, Baccarelli AA, Herreros-Martinez M, Tang WY, Bressler J, Fornage M, Umans JG, Tellez-Plaza M, Fallin MD, Zhao J, Cole SA

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