Faculty

Mandy Fretts

Associate Professor, Epidemiology


Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact


University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Lithium exposure in areas of the Western United States: Water and urinary levels in the Strong Heart Family Study.
(2026 Jul 23)
J Expo Sci Environ Epidemiol
Bannon EB, Lieberman-Cribbin W, Basu A, Mitra A, Izuchukwu C, Ross J, Azad S, Collado W, Kupsco A, Domingo Relloso A, Goldsmith J, Umans JG, Zhang Y, Ali T, Fretts AM, Zacher T, O'Leary R, O'Leary M, Bostick BC, Chillrud SN, Navas-Acien A, Nigra AE, Schilling K

Associations of drinking water and urinary uranium with incident diabetes among U.S. adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Family Study.
(2026 Jul 22)
Environ Res 306(Pt 3): 125295
Spaur M, Schilling K, Glabonjat RA, Basu A, Patterson KP, Lieberman-Cribbin W, Chen Q, Ravalli F, Galvez-Fernandez M, Factor-Litvak P, Chillrud S, Bostick BC, O'Leary R, O'Leary M, Zacher T, Zhang Y, Fretts AM, Umans JG, Barr RG, Shea SJ, Navas-Acien A, Nigra AE

Recruitment strategies for a randomized controlled trial in a rural American Indian community: the Cooking for Health Study.
(2026 Jun 27)
Trials
Green SA, O'Leary R, Huber CM, Thorndike AN, Best LG, Brown MC, O'Leary M, Umans J, Hager A, Whitebull R, Beresford S, Fretts AM

Vitamin D Deficiency and Markers of Liver Disease in American Indian Adolescents: The Strong Heart Family Study (SHFS).
(2026 Jun 3)
Biomedicines 14(6):
Reese JA, Davis E, Holloway P, Fretts AM, Ali T, Lee ET, Umans JG, Deen JF, Middleton MS, Loomba R, Sirlin CB, Cole SA, Zhang Y, Peck JD

Plasma Proteins Associated with Whole Grains and Fiber Intake in the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study.
(2026 Jun 2)
J Nutr
Feinberg A, Austin TR, Vasconcelos AG, Brody JA, Wiggins KL, Lemaitre RN, Fretts AM, Hasson DC, Sotoodehnia N, Floyd JS, Rebholz CM, Psaty BM, Kim H

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