Mandy Fretts

Associate Professor, Epidemiology



PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007



Cardiovascular Health Research Unit
Box 357236
1730 Minor Ave, Suite 1360
Seattle, WA 98101
University of Washington
Office F-250B
Box 357236
Department of Epidemiology
Seattle, WA 98195


I am most interested in observational and interventional research aimed at improving the cardio-metabolic health of American Indians. I have been actively involved with the Strong Heart Study, a longitudinal study of cardiovascular disease and its risk factors in 13 American Indian communities, for the past twelve years. My research efforts primarily focus on the association of physical activity, diet, a healthy lifestyle, or gene*diet interactions with diabetes-related phenotypes. I am also currently working on developing a culturally-appropriate diet intervention to promote diabetes control among American Indians.

In addition to my work with the Strong Heart Study, I am also actively involved in several on-going projects related to fatty acids, diet, diet*gene interactions, and cardiovascular outcomes in the Cardiovascular Health Study and the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology).

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Adapting a cooking, food budgeting and nutrition intervention for a rural community of American Indians with type 2 diabetes in the North-Central United States.
(2022 Nov 7)
Health Educ Res
Brown MC, Hawley C, Ornelas IJ, Huber C, Beat L, Thorndike AN, Beresford S, Howard BV, Umans JG, Hager A, Fretts AM

Educational and Clinical Associations With Longitudinal Cognitive Function and Brain Imaging in American Indians: The Strong Heart Study.
(2022 Oct 26)
Suchy-Dicey AM, Oziel K, Sawyer C, Olufadi Y, Ali T, Fretts AM, Umans JG, Shibata DK, Longstreth WT Jr, Rhoads K, Buchwald DS, Grabowski TJ

Diet Quality and Depression in a Cohort of American Indians: The Strong Heart Family Study.
Am Indian Alsk Native Ment Health Res 29(3): 90-121
Neff Warner LR, Littman AJ, O'Leary M, Sarche M, Nelson LA, Gray JS, Fretts AM

Urinary Zinc and Incident Type 2 Diabetes: Prospective Evidence From the Strong Heart Study.
(2022 Nov 1)
Diabetes Care 45(11): 2561-2569
Galvez-Fernandez M, Powers M, Grau-Perez M, Domingo-Relloso A, Lolacono N, Goessler W, Zhang Y, Fretts A, Umans JG, Maruthur N, Navas-Acien A

Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study.
J Alzheimers Dis 89(4): 1439-1452
de Oliveira Otto MC, Li XS, Wang Z, Siscovick DS, Newman AB, Lai HTM, Nemet I, Lee Y, Wang M, Fretts A, Lemaitre RN, Tang WHW, Lopez O, Hazen SL, Mozaffarian D

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