Mandy Fretts

Associate Professor, Epidemiology



PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007



University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195


Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis.
(2023 Mar 8)
Eur Heart J
Wang M, Li XS, Wang Z, de Oliveira Otto MC, Lemaitre RN, Fretts A, Sotoodehnia N, Budoff M, Nemet I, DiDonato JA, Tang WHW, Psaty BM, Siscovick DS, Hazen SL, Mozaffarian D

Plasma lipidomic profile of depressive symptoms: a longitudinal study in a large sample of community-dwelling American Indians in the strong heart study.
(2023 Jan 19)
Mol Psychiatry
Miao G, Deen J, Struzeski JB, Chen M, Zhang Y, Cole SA, Fretts AM, Lee ET, Howard BV, Fiehn O, Zhao J

Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.
(2023 Jan 18)
BMJ 380(): e072909
Ong KL, Marklund M, Huang L, Rye KA, Hui N, Pan XF, Rebholz CM, Kim H, Steffen LM, van Westing AC, Geleijnse JM, Hoogeveen EK, Chen YY, Chien KL, Fretts AM, Lemaitre RN, Imamura F, Forouhi NG, Wareham NJ, Birukov A, Jäger S, Kuxhaus O, Schulze MB, de Mello VD, Tuomilehto J, Uusitupa M, Lindström J, Tintle N, Harris WS, Yamasaki K, Hirakawa Y, Ninomiya T, Tanaka T, Ferrucci L, Bandinelli S, Virtanen JK, Voutilainen A, Jayasena T, Thalamuthu A, Poljak A, Bustamante S, Sachdev PS, Senn MK 2nd, Rich SS, Tsai MY, Wood AC, Laakso M, Lankinen M, Yang X, Sun L, Li H, Lin X, Nowak C, Ärnlöv J, Risérus U, Lind L, Le Goff M, Samieri C, Helmer C, Qian F, Micha R, Tin A, Köttgen A, de Boer IH, Siscovick DS, Mozaffarian D, Wu JH

High-Density Lipoprotein Lipidomics in Chronic Kidney Disease.
(2023 Mar 1)
Clin Chem 69(3): 273-282
Lidgard B, Hoofnagle AN, Zelnick LR, de Boer IH, Fretts AM, Kestenbaum BR, Lemaitre RN, Robinson-Cohen C, Bansal N

Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study.
(2022 Dec 18)
Clin Epigenetics 14(1): 177
Domingo-Relloso A, Gribble MO, Riffo-Campos AL, Haack K, Cole SA, Tellez-Plaza M, Umans JG, Fretts AM, Zhang Y, Fallin MD, Navas-Acien A, Everson TM

Show complete publication list