Faculty

Mandy Fretts

Associate Professor, Epidemiology

206-543-9236

Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact

206-543-9236

University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort.
(2025 Jun 5)
Environ Health Perspect
Lieberman-Cribbin W, Nigra AE, Kupsco A, Domingo-Relloso A, Schilling K, Zhang Y, Fretts AM, Cole S, Umans JG, Jarrett JM, Lewin M, Ruiz P, Li Z, Navas-Acien A

Ultra-processed foods, plant and animal sources, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study.
(2025 Jun 2)
Am J Clin Nutr
Feinberg A, Rebholz CM, Lemaitre RN, Fretts AM, Wiggins K, Sotoodehnia N, Psaty BM, Kim H

Uranium Exposure, Hypertension, and Blood Pressure in the Strong Heart Family Study.
(2025 Apr 24)
Prev Chronic Dis 22(): E16
Patterson KP, Gold AO, Spratlen MJ, Umans JG, Fretts AM, Goessler W, Zhang Y, Navas-Acien A, Nigra AE

Lipidomic Markers of Processed Meat and Unprocessed Red Meat Intake and Risk of Diabetes in American Indians.
(2025 Apr 23)
Diabetes Care
Wen X, Miao G, Fretts AM, Chen M, Zhang Y, Umans JG, Cole SA, Best LG, Fiehn O, Zhao J

Vitamin D Deficiency and Cardiovascular Disease Risk Factors Among American Indian Adolescents: The Strong Heart Family Study.
(2025 Apr 3)
Prev Chronic Dis 22(): E13
Reese JA, Davis E, Fretts AM, Ali T, Lee ET, Umans JG, Yarden R, Zhang Y, Peck JD

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