Faculty

Mandy Fretts

Associate Professor, Epidemiology


Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact


University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.
(2026 Mar 3)
medRxiv
Wang H, Nagarajan P, Miller CL, Bentley AR, Noordam R, Westerman KE, Brown MR, Kraja AT, O'Connell JR, Schwander K, Li C, Sanghvi MM, Song Y, Bartz TM, Braunack-Mayer V, Chen L, Du J, Dunca D, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Highland HM, Huang Z, Kang C, Lakka TA, Lefevre C, Luan J, Lyytikäinen LP, Missikpode C, Morrison JL, Palmer ND, Richmond A, Shahisavandi M, Tang J, van der Most PJ, Weiss S, Yu C, Zhu W, Ansari MAY, Anugu P, Aschard H, Ashok K, Attia JR, Bazzano LA, Cade BE, Campbell A, Dimitrov LM, Do A, Faquih T, FinesilverSmith SL, Fisher-Hoch SP, Fretts AM, Gharib SA, Goodarzi MO, Graff M, Gu C, Hanson P, He J, Heikkinen S, Hixson J, Hsu S, Kähönen M, Kho M, Kim H, Komulainen P, Launer LJ, Lemaitre RN, Study LC, McNeil JJ, McCormick JB, Nolte IM, Raffield LM, Raitakari OT, Ramírez J, Riha RL, Risch M, Risch L, Russ TC, Sarnowski C, Schram MT, Scott RJ, Sofer T, Sun Q, Völker U, Völzke H, Wang Y, van Dijk KW, Wood AC, Young KL, Zhang R, Zhu X, Below JE, Conen D, Cox SR, Fox ER, Franceschini N, Ghanbari M, Grabe HJ, Gudnason V, Hayward C, Holliday EG, Jaquish CE, Lacaze P, Lee S, Lehtimäki T, Liu CT, Morrison AC, North KE, Peyser PA, Province MA, Psaty BM, Rauramaa R, Rosendaal FR, Rotter JI, Snieder H, Wagenknecht LE, Wareham NJ, Giri A, Kelly TN, Munroe PB, Gauderman J, Winkler TW, de Vries PS, Rao DC, Manning AK, Chen H, de Las Fuentes L, Redline S, Meigs JB

Neighborhood Physical Disinvestment and Incident Diabetes between visits 1 and 2 of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
(2026 Mar 16)
J Urban Health
Smith CM, Spalt EW, Gallo LC, Carlson JA, Allison M, Thyagarajan B, Chambers EC, Pirzada A, Daviglus M, Cordero C, Qi Q, Austin E, Fretts AM, Ornelas I, Kaplan R, Kaufman JD, Mooney SJ

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease.
(2026 Feb 9)
Clin Epigenetics 18(1):
Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter JI, Rich SS, Budoff M, Tang W, DiDonato JA, Brody JA, Lemaitre RN, Fretts A, Sotoodehnia N, Psaty BM, Ordovás JM, Siscovick DS, Hazen SL, Mozaffarian D

Investigation of spillover effects of a sugar-sweetened beverage tax on beverage purchasing in a nearby, non-taxed area: A quasi-experimental, difference-in-differences analysis.
(2026)
PLoS One 21(2): e0340577
Neff Warner LR, Knox MA, Fretts AM, Saelens BE, Jones-Smith JC

Stroke Incidence and Smoking in American Indians: An Update from the Strong Heart Study.
(2026 Jan 6)
J Clin Med 15(2):
Niznik T, Reese JA, Deen JF, Ali T, Fretts AM, Umans JG, Zhang Y, Graffeo CS

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