MS
May 20, 2022
The Association of Severe Pain Experienced in the PICU and Health-Related Quality of Life Post-Discharge
BACKGROUND: A decline in health-related quality of life (HRQL) is common after pediatric intensive care unit (PICU) admission. There are few known modifiable risk factors during PICU admission for a clinically significant decline in HRQL. Chronic pain is known to be associated with low HRQL. We hypothesized that the duration of severe pain during PICU…
Concordance and discordance between patient-defined remission and remission based on validated patient-reported outcome measures among patients with ulcerative colitis and Crohns disease
Background: Patients with Inflammatory Bowel Disease (IBD, which includes ulcerative colitis and Crohn’s disease) experience periods of disease flares and remission. However, there may be differences in a patient’s own definition of remission and remission based on validated patient reported outcome (PRO) measures. This secondary data analysis seeks to inform our understanding of the concordance…
The effect of polygamy on loss of human papillomavirus detection in Senegalese women
Objectives: Persistent infection with human papillomavirus (HPV) can result in premalignant cervical lesions. Women in polygamous marriage are more likely to be re-exposed to HPV. Repeated exposure to HPV antigen may lead to shorter duration of infections by boosting the immune response. This study assessed the impact of polygamy on the clearance of HPV infection…
Migraine and the risk of different molecular subtypes of breast cancer
Survivors of hematopoietic cell transplant (HCT) are at risk for neurocognitive impairments, which can impact quality of life. Given limited long-term studies, we aimed to characterize the late neurocognitive outcomes in a cohort of adult HCT survivors. Eligible survivors (age ≥21y at time of HCT and alive ³2y followed HCT) completed a 60-question survey of…
Long-term Neurocognitive Outcomes in Adult Survivors of Hematopoietic Cell Transplant
Survivors of hematopoietic cell transplant (HCT) are at risk for neurocognitive impairments, which can impact quality of life. Given limited long-term studies, we aimed to characterize the late neurocognitive outcomes in a cohort of adult HCT survivors. Eligible survivors (age ≥21y at time of HCT and alive ³2y followed HCT) completed a 60-question survey of…
Invasive Mechanical Ventilation and Nutrition Intake in Association with Serious Outcomes among COVID-19 ICU Patients
Background: Worse clinical outcomes have been reported among critically ill COVID-19 patients who are admitted to an inpatient intensive care unit (ICU), especially those who require invasive mechanical ventilation (IMV). Patients on IMV do not receive any food or medication by mouth, during which their energy and protein needs are dependent on enteral nutrition (EN)…
Utilization of systemic therapy in cancer patients near the end-of-life in the pre- vs. post-checkpoint inhibitor eras
Introduction: Use of systemic therapy for advanced cancer patients near the end-of-life (EOL) is a low-value medical practice. However, immune checkpoint inhibitor (ICI) use at the EOL may be on the rise due to a favorable toxicity profile. We hypothesize that systemic therapy use in the last 30 days of life (DOL) increased since ICI…
May 16, 2022
Early Cumulative Fluid Balance and Outcomes in Pediatric Allogeneic Hematopoietic Cell Transplant Recipients with Acute Respiratory Failure
Objectives: To evaluate the associations between early cumulative fluid balance (CFB) and outcomes among critically ill pediatric allogeneic hematopoietic cell transplant (HCT) recipients with acute respiratory failure, and determine if these associations vary by treatment with renal replacement therapy (RRT). Methods: We performed a secondary analysis of a multicenter retrospective cohort of patients (1mo –…
Shifting Perspective – Can Behavioral Health Care Resources Reduce State Firearm Homicide Rates?
IntroductionFirearm homicide rates have risen steadily over the last decade. Two potential forms of intervention discussed by policy makers include firearm safety legislation and behavioral health resources. We sought to determine if a relationship exists between a state’s behavioral health resources and firearm related homicide rate.MethodsWe conducted a time-series cross-sectional analysis using the state and…
Life’s Simple 7 in relation to supraventricular and ventricular arrhythmias on extended ambulatory cardiac monitoring: The Multi-Ethnic Study of Atherosclerosis
Background: The Life’s Simple 7 (LS7) metric consists of seven health behaviors and measures that are known risk factors for cardiovascular disease. Relatively little is known about the association of LS7 score with cardiac arrhythmias.Methods: In the setting of the Multi-Ethnic Study of Atherosclerosis (MESA), we studied LS7 score, assessed at the 2010-2102 study visit,…
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