MS
December 21, 2022
Diet Quality and Kidney Outcomes in Adolescent and Adult American Indians: The Strong Heart Family Study
Background: The burden of chronic and end stage kidney disease (CKD and ESKD) is exceedingly high amongst American Indians (AI). We sought to examine the relationship of diet quality, a modifiable risk factor, and kidney outcomes in AI adolescents and young adults, hypothesizing that healthier diets are associated with lower odds of incident albuminuria and…
Development of CPAP Dose Response for Patients with Obstructive Sleep Apnea: Secondary Analysis
Background: First-line treatment for obstructive sleep apnea (OSA) is continuous positive airway pressure therapy (CPAP). Although CPAP is efficacious, the definition of adequate use (effectiveness) is known to be arbitrary. We aimed to characterize a CPAP dose response for short term outcomes, including sleepiness severity and quality of life. Methods We performed secondary analysis on…
Left atrial strain and the risk of arrhythmias on extended ambulatory cardiac monitoring: the Multi-Ethnic Study of Atherosclerosis
Background: Abnormalities in left atrial (LA) function can be identified before the development of overt LA structural changes. Little is known about the relationship between LA function and the risk of subclinical atrial and ventricular arrhythmias.Methods: 1,441 participants of the Multi-Ethnic Study of Atherosclerosis completed speckle-tracking echocardiography and cardiac monitoring during 2016-2018 (mean age 73…
Association of media and messaging on the impact of the Seattle sugar-sweetened beverage tax
Consumption of sugar-sweetened beverages (SSB) has been linked with poor health outcomes such as Type 2 Diabetes, cardiovascular disease, metabolic syndrome, and obesity. Public health and policy experts have been increasingly turning to fiscal policy as a potential strategy to lower consumption of excess sugar from SSBs. However, there is evidence that the public acceptance…
The association of dietary factors and bacterial alpha diversity in the colorectal tumor-associated microbiome
Background: Aspects of the gut microbiome, such as microbial diversity, are related to the development and prognosis of colorectal cancer (CRC). Diet has been linked to the gut microbiome but no studies have considered the association of diet and microbial diversity in the tumor-associated microbiome. The goal of this study was to determine if dietary…
Delayed mortality among solid organ transplant recipients hospitalized for COVID-19
Introduction: Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month of illness onset. Delayed mortality in SOT recipients hospitalized for COVID-19 has not been fully examined.Methods: We used data from a multicenter registry to calculate mortality by 90 days following initial SARS-CoV-2 detection in SOT recipients hospitalized for…
May 20, 2022
Modeling to Inform the Delivery of HIV Pre-Exposure Prophylaxis in Sub-Saharan Africa
Daily oral tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) as HIV pre-exposure prophylaxis (PrEP) is a safe and effective method for HIV prevention and offers potential to substantially reduce HIV incidence in sub-Saharan Africa. Mathematical models are commonly used to project the cost-effectiveness of investments in PrEP in comparison to alternative resource allocation strategies. Predictive modeling…
A longitudinal study of the association between internalizing problems during early adolescence and alcohol and cannabis use disorder at age 18 in a community sample
Introduction: Substance use disorders, such as alcohol use disorder (AUD) and cannabis use disorder (CUD), in young adults are an important public health concern. AUD and CUD may have deleterious impacts on the ongoing maturation of the brain and lead to impaired thinking, memory, emotional, and learning functions. Research on how internalizing problems among adolescents…
Clinical and Biomarker Modifiers of Vitamin D Treatment Response: The Multi-Ethnic Study of Atherosclerosis
Background: Different 25-hydroxyvitamin D (25(OH)D) thresholds for treatment with vitamin D supplementation have been suggested, and are derived almost exclusively from observational studies. Whether other characteristics including race/ethnicity, body mass index (BMI), and estimated glomerular filtration rate (eGFR) should also influence the threshold for treatment is unknown. Objective: Identify clinical and biomarker characteristics that modify…
Development and validation of a biomarker-based model to predict persistent hypoxemic respiratory failure among mechanically ventilated adults
Background. Acute hypoxemic respiratory failure (HRF) requiring invasive mechanical ventilation (IMV) is a common and morbid condition, but treatment is largely supportive and most pharmacologic trials have been negative. The early clinical trajectory is heterogeneous, with most patients resolving within days while others require prolonged IMV, which impairs both clinical resource allocation and the detection…
Previous page Next page