Department of Epidemiology

MPH


January 12, 2021

Diet quality and depressive symptoms in a cohort of American Indians: The Strong Heart Family Study

Background: Higher diet quality has been shown to be associated with a lower risk of depression compared to lower diet quality, though this relationship has not been studied in American Indians (AIs). We examined the relationship of diet quality with incidence of depressive symptoms in a prospective, family-based cohort of 1,100 AIs ≥14 years of…


November 25, 2020

Effect modification of the alcohol – colorectal cancer association

INTRODUCTION Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a meta-analysis of 16 studies of CRC to examine the shape of the alcohol-CRC association, investigate potential effect…


Trends in incidence of vancomycin-resistant enterococcus colonization and bacteremia among hematopoietic cell transplant recipients at a large comprehensive cancer care center

BACKGROUND Vancomycin-resistant Enterococcus (VRE) are important hospital-acquired pathogens among hematopoietic cell transplant (HCT) recipients. We examined the incidence and outcomes of patients with VRE colonization and bacteremia (VREB) over a ten-year period at a center that routinely screens and uses barrier precautions for VRE. METHODS Adults receiving their first allogeneic HCT at our center between…


Effects of Intubation Location on Risk of Ventilator Associated Events

BACKGROUND Ventilation is a crucial tool in modern medicine that allows for advanced respiratory support in critically ill patients. However, prolonged ventilation has been found to be linked with ventilator-associated conditions (VACs), which in turn are associated with multiple adverse hospital outcomes. OBJECTIVES To evaluate the association between intubation practices (using intubation locations as a…


Stressful Life Events in Pregnancy and Postpartum Depressive Symptoms among Women in Washington State

BACKGROUND Stressful life events (SLEs) such as job loss or death of a loved one are common in pregnancy. Studies have shown that women with SLEs during pregnancy are more likely to develop postpartum depressive symptoms (PDS). This study examined the association between stressful life events (SLEs) experienced one year before delivery and postpartum depressive…


Risk factors of opioid-related overdose among opioid users in an acute care setting: a prospective cohort study

OBJECTIVE Opioid-related overdoses cause substantial morbidity and mortality in the United States. This prospective cohort analysis investigated the associations between demographics, overdose history, and drug use and future medically attended opioid overdose events (both fatal and non-fatal). METHODS Baseline data from 241 high-risk opioid users were collected from 2013-2015 in Washington State. These data were…


Patterns in completion of colorectal cancer screening using fecal immunochemical tests in a health maintenance organization setting

BACKGROUND Fecal immunochemical test (FIT) is a home-based stool test for colorectal cancer (CRC) screening and an effective means to improve rates of CRC screening overall, and thus reduce CRC mortality. We investigated and described patient characteristics associated with completion of FIT once a physician order has been placed. METHODS Enrollees of Kaiser Permanente Washington…


Correlates of HPV vaccination and association with HPV-16 and HPV-18 DNA detection in young women

BACKGROUND Human Papillomavirus (HPV) infection, primarily with high-risk (HR) types 16 and 18, is responsible for causing 17,600 cancers in women and 9,300 cancers in men in the US each year. However, the availability of the HPV vaccination series has substantially reduced the prevalence of vaccine-type HPV. METHODS We employed a cross-sectional study design to…


Prevalence and Risk Factors for Syphilis and Hepatitis B Co-Infection Among Newly-Diagnosed HIV-Infected Adults in Durban, South Africa

OBJECTIVE To estimate the prevalence of and risk factors for co-infection with syphilis or hepatitis B (HBV) among newly-diagnosed HIV-infected adults in an urban township of KwaZulu-Natal. METHODS We conducted a cross-sectional study of newly-diagnosed HIV infected adults at an outpatient HIV clinic in Durban, South Africa. Baseline demographics, socio-economic indicators, behavioral factors, substance use…


High cervical IL-6 levels predict spontaneous preterm birth among women in western Kenya

BACKGROUND Spontaneous preterm birth (sPTB) increases neonatal morbidity and mortality. Infection and subsequent inflammation of the genital tract have been identified as risk factors for sPTB, however the role of cytokines in this relationship remains unclear. OBJECTIVES This study determined the association between genital cytokines and sPTB, identified cofactors for high genital cytokine levels, and…



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