Graduate
March 13, 2024
Incidence and Outcomes of Late-Onset Right Ventricular Failure in Patients with Left Ventricular Assist Device
Right Ventricular Failure (RVF) is an incompletely understood complication observed in patients undergoing durable left ventricular assist device (LVAD) implantation. Prior research has primarily concentrated on early post-implantation RVF. This study seeks to characterize the incidence and clinical features associated with late-onset RVF in LVAD patients. Methods: This retrospective cohort study included individuals undergoing LVAD…
December 26, 2023
Clinical Trial Designs that Utilize Historical Controls in the setting of Cystic Fibrosis
In certain rare disease settings, traditional randomized controlled trials face ethical and feasibility challenges that can exclude their use. Adequate participant recruitment can be prohibitively difficult, and a large placebo control arm could unethically expose vulnerable participants to risk. Development of new therapeutics for these diseases still require regulatory grade evidence of a treatment effect,…
Changes in vaginal bacteria and inflammatory mediators from periconception through early-postpartum in a cohort of HIV-negative Kenyan women
Women’s increased risk of HIV acquisition during pregnancy and the postpartum period maybe mediated by changes in vaginal microbiota and/or cytokines. Methods: A cohort of HIV-1-seronegative Kenyan women contributed vaginal fluid samples at six pregnancy time points: periconception, positive pregnancy test, first trimester, second trimester, third trimester and postpartum. Concentrations of vaginal bacteria previously associated…
Characterizing SARS-CoV-2 infection burden and COVID-19 vaccination intent and uptake in congregate shelters in Seattle, WA
Community-based surveillance studies can be appropriately leveraged to characterize the burden of emerging pathogens, especially in hard-to-reach populations such as people experiencing homelessness (PEH). Prior respiratory viral studies among PEH populations have shown evidence of increased morbidity and mortality compared to the general population, likely associated with a high prevalence of co-occurring health conditions, though…
Understanding methamphetamine and opioid co-use: national trends and local harm reduction strategies for overlapping illicit drug use
In the past 20 years, the United States has seen a remarkable increase the use of both methamphetamine and opioids, used concurrently or simultaneously. A more detailed picture is needed to understand where methamphetamine-opioid co-use is increasing nationally, as well as the characteristics of people who co-use. Methamphetamine-opioid co-use has become particularly prevalent in Seattle,…
The Impact of a Walk-In HIV Care Model for People who are Incompletely Engaged in Care: the Moderate Needs (MOD) Clinic
The MOD Clinic in Seattle, Washington provides walk-in primary care for people with HIV who are incompletely engaged in standard care.Methods: We evaluated HIV outcomes among patients enrolled in the MOD Clinic (within group analysis) and, separately, among MOD patients vs. patients who were MOD-eligible but did not enroll (comparison group analysis) during 1/1/2018-9/30/2021. The…
Associations of Maternal Exposure and Characteristics with Placental Transcription Regulation and Consequences on Fetal Growth
The placenta is a key organ in pregnancy and its dysfunction can lead to pregnancy complications as well as adverse maternal and fetal outcomes. While evidence for adverse consequences of maternal characteristics (such as obesity) or environmental exposures (e.g. particulate matter under 2.5 μm in diameter, PM2.5) on the course and outcomes of pregnancy has…
Tuberculosis Risk and Prevention: Findings from Domestic and Global Cohorts
Tuberculosis is a highly infectious disease, leading to disproportionate morbidity and mortality amongst vulnerable populations such as immigrants, adolescents and young adults (AYA), and people living with HIV (PLWHIV). Approximately one quarter of the global population is infected with TB, which can develop into TB disease due to a myriad of factors. There has been…
Difficulty Walking and Contraceptive Use among Reproductive Aged Women: The 2019 CDC’s Behavioral Risk Factor Surveillance System (BRFSS)
A disproportionate number of physically disabled women face barriers to timely and appropriate reproductive healthcare. Yet, little is known about the relationships between functional limitations and contraceptive use. Further, racial minorities (e.g., Black and Hispanic disabled women) in the United States frequently experience racial inequality related compounding factors that exacerbate lack of access to quality…
Identifying opportunities to reduce cervical cancer prevention disparities in Western Washington
Cervical cancer screening (CCS) and human papillomavirus (HPV) vaccination are at the heart of the global cervical cancer elimination movement. However, in the United States (US), less than two thirds of age-eligible adolescents are up to date for HPV vaccination, and screening coverage among minorities and immigrants is still low. This dissertation addressed critical knowledge…
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