Plasma metabolomic profiles associated with cardiovascular disease in type 2 diabetes from the Trans-Omics for Precision Medicine (TOPMed) program.
(2026 Apr 26)
Atherosclerosis 417(): 120758
Zhang Y, Nguyen NQH, Hanson PA, Sevilla-Gonzalez M, Haessler J, Sarnowski C, Yao J, Yu B, Jamshidi A, Boerwinkle E, Brown MR, Chen ZZ, Ida Chen YD, Clish C, DiCorpo D, Durda P, Gerszten R, Goodarzi MO, Guo X, Heard-Costa NL, Johnson WC, Kooperberg C, Pankow JS, Post WS, Reiner AP, Rich SS, Rotter JI, de Vries PS, Wood AC, Taylor KD, Manning AK, Dupuis J, Meigs JB, Liu CT

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging.
(2026 Mar 19)
Am J Respir Crit Care Med
Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O'Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan R, Oelsner EC, Manichaikul A, Bick AG, Scheet P, Reiner AP, NHLBI Trans-Omics for Precision Medicine Consortium, Jakubek YA, Auer PL, Cho MH, DeMeo DL

Plasma proteomics link menopause timing to brain aging and dementia risk.
(2026 Apr 24)
medRxiv
Alexander MW, Wood B, Oh HS, Bot VA, Borger J, Galbiati F, Walker KA, Resnick SM, Ochs-Balcom HM, Wyss-Coray T, Kooperberg C, Reiner AP, Jacobs EG, Rabin JS, Casaletto KB, Saloner R

Clonal Hematopoiesis and Risk of Stroke: Evidence From Over 800 000 Individuals Across 3 Cohorts.
(2026 Apr 8)
Stroke
Zhao K, Pershad Y, Xue L, Vlasschaert C, Corty RW, Heimlich JB, Kooperberg C, Reiner AP, Bick AG

Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies.
(2026 Apr 2)
Am J Hum Genet 113(4): 828-841
Hu X, Araujo DS, Khunsriraksakul C, Wang L, Sun Q, Wen J, Zhou L, Ekunwe L, Lange LA, Lange EM, Montgomery SB, Reiner AP, Aguet F, Ardlie KG, Lappalainen T, Gignoux CR, Burchard EG, Taylor KD, Guo X, Rotter JI, Rich SS, Cornell E, Durda P, Tracy RP, Liu Y, Johnson WC, Papanicolaou GP, Perera MA, Cho MH, Liu DJ, Raffield LM, Li Y, TOPMed Multi-Omics Working Group, Wheeler HE, Im HK, Manichaikul A