Faculty

Nona Sotoodehnia

Adjunct Professor, Epidemiology
Professor, Medicine - Cardiology
Co-Director, Cardiovascular Health Research Unit, Medicine - Cardiology
John Laughlin Endowed Professorship in Cardiovascular Research, Medicine - Cardiology

206-287-2777

Education

MPH Harvard School of Public Health, 1996
MD Harvard Medical School, 1996
BS Massachusetts Institute of Technology, 1991

Contact

206-287-2777

Box 359748
WA

Bio

Dr. Sotoodehnia, the John and Cookie Laughlin Endowed Professor in Cardiology, is co-director of the Cardiovascular Health Research Unit. She is a general cardiologist at Harborview Medical Center.

She conducts research on the genomics and epidemiology of cardiovascular diseases and risk factors. Her research focus includes cardiac arrhythmias and sudden cardiac arrest, diabetes and coronary heart disease. She and her group are leading efforts in precision medicine, examining drug-gene interactions, risk prediction and drug safety. Her work investigates gender and ethnic differences in cardiovascular risk and outcomes. In addition, she has a long interest in international health and is helping lead efforts in cardiovascular treatments in Nepal.

Research Interests

  • Preventive cardiology
  • Arrhythmias including sudden cardiac death and atrial fibrillation
  • Coronary heart disease
  • Precision medicine
  • International health
  • Diabetes and gender 
  • Ethnic differences in cardiovascular risk and outcomes

Recent Publications (PubMed)

Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.
(2026 Jun)
JACC Clin Electrophysiol 12(6): 1445-1468
Hanna P, Boyle PM, Caldwell JL, El Refaey M, Goodyer WR, Khurshid S, Mesubi OO, Palatinus JA, Pfenniger A, Ajijola OA, Albert CM, Armoundas AA, Benjamin EJ, Clancy CE, Al-Khatib SM, Bilchick K, Delmar M, Donahue JK, Fishman GI, Goldenberg I, Gourdie RG, Huang DT, Knollmann BC, Ko D, Lubitz SA, Marchlinski FE, Marston NA, Moskowitz IP, Noseworthy PA, Prather RS, Radwański PB, Rajamani S, Rentschler S, Roden DM, Russo A, Saffitz JE, Sotoodehnia N, Webster G, Wu SM, Adhikari BB, Bandettini WP, Desvigne-Nickens P, Shanbhag SM, Schopfer D, Sopko G, Tjurmina OA, Balijepalli RC, McNally E, Shivkumar K

Plasma Proteins Associated with Whole Grains and Fiber Intake in the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study.
(2026 Jun 2)
J Nutr
Feinberg A, Austin TR, Vasconcelos AG, Brody JA, Wiggins KL, Lemaitre RN, Fretts AM, Hasson DC, Sotoodehnia N, Floyd JS, Rebholz CM, Psaty BM, Kim H

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.
(2026 May 4)
Res Sq
Jurgens SJ, Enzan N, Dinsmore IR, Choi SH, Luo J, Lipov A, Hartle C, Wang X, Marston NA, Weng LC, Melloni GE, Chalazan B, Gray MP, Pirruccello JP, Diaz A, Chaffin MD, Ornelas-Loredo A, Tang O, Darbar FA, Kany S, Chen Y, von Falkenhausen AS, Morrison AC, Natale A, Tveit A, Geelhoed B, Cade B, Van Wagoner DR, Haase D, Soliman EZ, Davogustto GE, Calkins H, Anderson JL, Brody JA, Barnard J, Hokanson JE, Smith JD, Bis JC, Young K, Johnson LS, Long L, Risch L, Gula LJ, Kwee LC, Kühne M, Preuss M, Gupta N, Nafissi NA, Smith NL, Nilsson PM, van der Harst P, Wells QS, Judy RL, Schnabel RB, Johnson R, Smit RA, Gabriel S, Knight S, Furukawa T, Min YI, Yoneda ZT, Laksman ZW, Alonso A, Psaty BM, Albert CM, Arking DE, Roden DM, Chasman DI, Rader DJ, Conen D, McManus DD, Fatkin D, Boerwinkle E, Marcus GM, Christophersen IE, Smith JG, Roberts JD, Raffield LM, Shoemaker MB, Cho MH, Cutler MJ, Chung MK, Olesen MS, Sinner MF, Sotoodehnia N, Kirchhof P, Loos RJ, Nazarian S, Mohanty S, Damrauer SM, Kaab S, Heckbert SR, Redline S, Shah SH, Tanaka T, Ebana Y, Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Lubitz SA, Lunetta KL, Benjamin EJ, Rienstra M, Figtree GA, Darbar D, Bezzina CR, Ruff CT, Sabatine MS, Mirshahi T, Ellinor PT

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease.
(2026 Feb 9)
Clin Epigenetics 18(1):
Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter JI, Rich SS, Budoff M, Tang W, DiDonato JA, Brody JA, Lemaitre RN, Fretts A, Sotoodehnia N, Psaty BM, Ordovás JM, Siscovick DS, Hazen SL, Mozaffarian D

Sex Hormones and Repolarization Dynamics During the Menstrual Cycle in Women Treated With QT-Prolonging Drugs.
(2026 Jan)
Ann Noninvasive Electrocardiol 31(1): e70151
San A, Goldenberg I, Younis A, Cutter K, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Polonsky B, Zareba W, Aktaş MK

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