Faculty

Nicholas L. Smith

Professor, Epidemiology

206-221-1279
nlsmith@uw.edu

Education

PhD Epidemiology, University of Washington, 1997
MPH Epidemiology/Biostatistics, University of California (Berkeley), 1993
BA Social Sciences, University of California (Irvine), 1987

Contact

206-221-1279
nlsmith@uw.edu

Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 886
Seattle, WA 98195
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Bio

Dr. Smith is Professor of Epidemiology and Director of the VA Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System

Research Areas

Research Interests

My research interests within cardiovascular epidemiologic research are wide and include investigations of inherited and acquired risk factors for arterial and venous thrombosis, diabetes, and heart failure. A major focus of my research in the past 15 years has been on genetic association studies, first conducted in the local setting and now being orchestrated internationally. Early work was conducted at Group Health Research Institute and involved a series of case-controls studies conducted with colleagues at the University of Washington. These studies addressed primarily pharmaco and pharmaco-genetic epidemiologic questions related to myocardial infarctions, stroke, and venous thrombosis. More recently, I have been involved in 2 large international genetics consortia, the Cohorts of Heart and Aging Genetic Epidemiology (CHARGE) Consortium and the International Network of Venous Thrombosis (INVENT) Consortium. In CHARGE, I co-convene 2 working groups, the CHARGE Hemostasis Working Group and the CHARGE Heart Failure Working Group. I am also a co-convener of the International Network on Venous Thrombosis (INVENT) consortium. For these consortia, I provide leadership in the conduct of intermediate and clinical phenotype association studies using genome-wide and exome-wide markers and exome sequencing. I am also the director of the Seattle Epidemiologic Research and Information Center (ERIC), a program of the Department of Veterans Affairs (VA) Cooperative Studies Program (CSP). The VA CSP is intimately involved in the VA’s Million Veteran Program (MVP), which is collecting DNA, lifestyle questionnaires from over a 1,000,000 Veterans who use the Veterans Health Administration for their care.

Recent Publications (PubMed)

WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.
(2023 Aug 22)
medRxiv
Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS, Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Marchand LL, McDonald MN, McHugh CP, Morrison AC, Naseri T, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, O'Connell J, O'Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Chen YI, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, Irvin MR, Kooperberg C, Minster RL, Mitchell BD, Nouraie M, Psaty BM, Raffield LM, Reiner AP, Rich SS, Rotter JI, Shoemaker MB, Smith NL, Taylor KD, Telen MJ, Weiss ST, Zhang Y, Costa NH, Sun YV, Lin X, Cupples LA, Lange LA, Liu CT, Loos RJF, North KE, Justice AE
Early Outcomes of SARS-CoV-2 Infection in a Multisite Prospective Cohort of Inpatient Veterans.
(2023 Jul)
Open Forum Infect Dis 10(7): ofad330
Ross JM, Sugimoto JD, Timmons A, Adams J, Deardoff K, Korpak A, Liu C, Moore K, Wilson D, Bedimo R, Chang KM, Cho K, Crothers K, Garshick E, Gaziano JM, Holodniy M, Hunt CM, Isaacs SN, Le E, Jones BE, Shah JA, Smith NL, Lee JS, EPIC Investigators
Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism.
(2023 Sep 26)
Blood Adv 7(18): 5341-5350
Ward J, Le NQ, Suryakant S, Brody JA, Amouyel P, Boland A, Bown R, Cullen B, Debette S, Deleuze JF, Emmerich J, Graham N, Germain M, Anderson JJ, Pell JP, Lyall DM, Lyall LM, Smith DJ, Wiggins KL, Soria JM, Souto JC, Morange PE, Smith NL, Trégouët DA, Sabater-Lleal M, Strawbridge RJ
Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.
(2023 Jun 12)
medRxiv
Huffman JE, Nicolas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessle J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BA, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, He G, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJ, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MP, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson P, Ben-Shlomo Y, Blangero J, Boomsma D, Cox SR, Dehghan A, Eriksson JG, Fiorillo E, Fornage M, Hansen T, Hayward C, Ikram MA, Jukema JW, Kardia SL, Lange LA, März W, Mathias RA, Mitchell BD, Mook-Kanamori DO, Morange PE, Pedersen O, Pramstaller PP, Redline S, Reiner A, Ridker PM, Silverman EK, Spector TD, Völker U, Wareham N, Wilson JF, Yao J, VA Million Veteran Program, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Trégouët DA, Johnson AD, Wolberg AS, de Vries PS, Sabater-Lleal M, Morrison AC, Smith NL
Development of a computable phenotype using electronic health records for venous thromboembolism in medical inpatients: the Medical Inpatient Thrombosis and Hemostasis study.
(2023 May)
Res Pract Thromb Haemost 7(4): 100162
Thomas RM, Wilkinson K, Koh I, Li A, Warren JSA, Roetker NS, Smith NL, Holmes CE, Plante TB, Repp AB, Cushman M, Zakai NA
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