Education
PhD Epidemiology, University of Washington, 1997
MPH Epidemiology/Biostatistics, University of California (Berkeley), 1993
BA Social Sciences, University of California (Irvine), 1987
Contact
206-221-1279
nlsmith@uw.edu
Department of Epidemiology
Hans Rosling Center for Population Health, 886
Seattle, WA 98195
Bio
Dr. Smith is Professor of Epidemiology and Director of the VA Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System
Research Interests
My research interests within cardiovascular epidemiologic research are wide and include investigations of inherited and acquired risk factors for arterial and venous thrombosis, diabetes, and heart failure. A major focus of my research in the past 15 years has been on genetic association studies, first conducted in the local setting and now being orchestrated internationally. Early work was conducted at Group Health Research Institute and involved a series of case-controls studies conducted with colleagues at the University of Washington. These studies addressed primarily pharmaco and pharmaco-genetic epidemiologic questions related to myocardial infarctions, stroke, and venous thrombosis. More recently, I have been involved in 2 large international genetics consortia, the Cohorts of Heart and Aging Genetic Epidemiology (CHARGE) Consortium and the International Network of Venous Thrombosis (INVENT) Consortium. In CHARGE, I co-convene 2 working groups, the CHARGE Hemostasis Working Group and the CHARGE Heart Failure Working Group. I am also a co-convener of the International Network on Venous Thrombosis (INVENT) consortium. For these consortia, I provide leadership in the conduct of intermediate and clinical phenotype association studies using genome-wide and exome-wide markers and exome sequencing. I am also the director of the Seattle Epidemiologic Research and Information Center (ERIC), a program of the Department of Veterans Affairs (VA) Cooperative Studies Program (CSP). The VA CSP is intimately involved in the VA’s Million Veteran Program (MVP), which is collecting DNA, lifestyle questionnaires from over a 1,000,000 Veterans who use the Veterans Health Administration for their care.
Recent Publications (PubMed)
(2025 Sep 4)
J Thromb Thrombolysis
Frauenheim AC, Wiggins KL, Lemaitre RN, Smith NL, Harrington LB
(2025 Aug 14)
Blood
Munsch G, Thibord F, Bezerra OC, Brody JA, van Hylckama Vlieg A, Gourhant L, Chen MH, Samaria F, Germain M, Caro I, Suchon P, Olaso R, Wiggins KL, Saut N, Besse C, Goumidi L, Bacq D, Harrington LB, Boland A, Emmerich J, Smadja DM, Lemarie CA, Danckwardt S, Debette S, Deleuze JF, Jacqmin-Gadda H, Rodger MA, Gagnon F, Rosendaal FR, Johnson AD, Smith NL, Couturaud F, Morange PE, Tregouet DA
(2025 Jul 1)
JAMA Netw Open 8(7): e2522080
Hosseini R, Garshick E, Slade MD, Timmons A, Korpak AM, Smith NL, Nakayama KS, Baird CP, Ciminera P, Kheradmand F, Fan VS, Hart JE, Koutrakis P, Kuschner WG, Ioachimescu OC, Jerrett M, Montgrain PR, Proctor SP, Wendt CH, Wongtrakool C, Wan ES, Blanc PD, Redlich CA
(2025 Jul 17)
J Thromb Haemost
Zakai NA, Wilkinson K, Sparks AD, Packer RT, Roetker NS, Repp AB, Gergi M, Holmes C, Cushman M, Plante TB, Al-Samkari H, Pishko AM, Wood WA, Masias C, Gangaraju R, Li A, Garcia D, Wiggins KL, Schaefer JK, Smith NL, Ferraris A, Martin KA, Terrell DR, McClure LA
(2025 Oct 14)
Blood Adv 9(19): 4850-4859
Wolford BN, Zhao QY, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton BM, Desch KC, Thibord F, Klarin D, Johnson AD, Trégouët DA, Damrauer SM, Smith NL, Lo Faro V, Tsuo K, Daly MJ, Neale BM, Zhou W, Willer CJ, Shavit JA, Surakka I
Show complete publication list
In the News
SPH News, 04/02/2018
HCP Live, 10/04/2013
Bloomberg Businessweek, 09/30/2013
JAMA Internal Medicine, 09/30/2013