Isaac C. Rhew

Adjunct Research Associate Professor, Epidemiology
Research Associate Professor, Psychiatry and Behavioral Sciences



PhD Epidemiology, University of Washington, 2009
MPH Epidemiology, University of Washington, 2006
AB Psychology, Stanford University, 1995



Center for the Study of Health and Risk Behaviors
Box 354944
1100 NE 45th St., #300
Seattle, WA 98105


Dr. Rhew is a psychiatric epidemiologist with research interests in the etiology of and preventive interventions for substance use and mental health problems particularly regarding influences of area-level social and physical context on these outcomes. In addition, he is interested in epidemiologic and applied statistical methods especially for longitudinal and multi-level studies.

Research Interests

  • Etiology and prevention of mental health and substance use problems
  • Social determinants of health
  • Area-level contextual factors and health
  • Epidemiologic methods
  • Applied statistical methods
  • Co-occurrence of substance use and internalizing problems

Recent Publications (PubMed)

The longitudinal association of cumulative depression with cannabis use disorder among young adults.
(2024 Jun 20)
J Stud Alcohol Drugs
Rhew IC, Oesterle S, Kuklinski MR, Guttmannova K, Cadigan JM

Young Adult Alcohol and Cannabis Impaired Driving After the Opening of Cannabis Retail Stores in Washington State.
(2024 Apr 25)
Prev Sci
Hultgren BA, Calhoun BH, Fleming CB, Lyons VH, Rhew IC, Larimer ME, Kilmer JR, Guttmannova K

Confirmatory Factor Analysis and Validation of the Sexual and Reproductive Empowerment Scale for Adolescents and Young Adults in Kenya.
(2024 Jun)
Stud Fam Plann 55(2): 85-103
Zia Y, Upadhyay U, Rhew I, Kimanthi S, Congo O, Onono M, Barnabas R, Mugo N, Bukusi EA, Harrington EK

Is the 21st birthday a turning point for alcohol and cannabis use? A monthly study of young adults.
(2024 May)
Alcohol Clin Exp Res (Hoboken) 48(5): 955-966
Rhew IC, Gilson MS, Fleming CB, Walukevich-Dienst K, Guttmannova K, Patrick ME, Lee CM

A randomized controlled trial testing theory-driven enhancements to increase the efficacy of and engagement in a brief cognitive-behavioural therapy text-message intervention for co-occurring posttraumatic stress disorder symptoms and alcohol misuse.
(2024 Mar 26)
Br J Clin Psychol
Bedard-Gilligan M, Lindgren K, Dworkin E, Tristao T, Kaysen D, Rhew I

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