Isaac Rhew

Adjunct Research Associate Professor, Epidemiology
Research Associate Professor, Psychiatry and Behavioral Sciences



PhD Epidemiology, University of Washington, 2009
MPH Epidemiology, University of Washington, 2006
AB Psychology, Stanford University, 1995



Center for the Study of Health and Risk Behaviors
Box 354944
1100 NE 45th St., #300
Seattle, WA 98105


Dr. Rhew is a psychiatric epidemiologist with research interests in the etiology of and preventive interventions for substance use and mental health problems particularly regarding influences of area-level social and physical context on these outcomes. In addition, he is interested in epidemiologic and applied statistical methods especially for longitudinal and multi-level studies.

Research Interests

  • Etiology and prevention of mental health and substance use problems
  • Social determinants of health
  • Area-level contextual factors and health
  • Epidemiologic methods
  • Applied statistical methods
  • Co-occurrence of substance use and internalizing problems

Recent Publications (PubMed)

Cognitive Processing Therapy or Relapse Prevention for comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A randomized clinical trial.
PLoS One 17(11): e0276111
Simpson TL, Kaysen DL, Fleming CB, Rhew IC, Jaffe AE, Desai S, Hien DA, Berliner L, Donovan D, Resick PA

Associations of Cumulative and Point-in-Time Neighborhood Poverty and Walkability with Body Mass from Age 30 to 39.
(2022 Oct 12)
J Urban Health
Le VT, Rhew IC, Kosterman R, Lovasi GS, Frank LD

Substance-Specific Risk Factors among Young Adults: Potential Prevention Targets across Cannabis-Permissive Environments.
Subst Use Misuse 57(13): 1923-1930
Guttmannova K, Oesterle S, Skinner ML, Kuklinski MR, Hultgren B, Rhew IC, Parker M, Briney JS, White HR

Substance-Specific Risk Factors for Cannabis and Alcohol Use Among Young Adults Following Implementation of Nonmedical Cannabis Legalization.
(2022 Sep 17)
Prev Sci
Gilson MS, Kilmer JR, Fleming CB, Rhew IC, Calhoun BH, Guttmannova K

Development of StressCheck: A telehealth motivational enhancement therapy to improve voluntary engagement for PTSD treatment among active-duty service members.
(2022 Aug)
Contemp Clin Trials 119(): 106841
Kaysen D, Walton TO, Rhew IC, Jaffe AE, Pierce AR, Walker DD

Show complete publication list