Faculty

Alexander Reiner

Research Professor, Epidemiology

206-667-2710

Education

MD Internal Medicine, Johns Hopkins University, 1984
MSc Epidemiology, University of Washington, 2001

Contact

206-667-2710

Fred Hutch Cancer Center
Box 358080
WHI Clinical Coordinating Ctr / Public Health Sciences
M3-A4
Seattle, WA

Research Interests

Genetic epidemiology of atherosclerotic, thrombotic and cardiovascular disease; population biology; genomics

Recent Publications (PubMed)

Clonal Hematopoiesis and Risk of Stroke: Evidence From Over 800 000 Individuals Across 3 Cohorts.
(2026 Apr 8)
Stroke
Zhao K, Pershad Y, Xue L, Vlasschaert C, Corty RW, Heimlich JB, Kooperberg C, Reiner AP, Bick AG

Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies.
(2026 Apr 2)
Am J Hum Genet 113(4): 828-841
Hu X, Araujo DS, Khunsriraksakul C, Wang L, Sun Q, Wen J, Zhou L, Ekunwe L, Lange LA, Lange EM, Montgomery SB, Reiner AP, Aguet F, Ardlie KG, Lappalainen T, Gignoux CR, Burchard EG, Taylor KD, Guo X, Rotter JI, Rich SS, Cornell E, Durda P, Tracy RP, Liu Y, Johnson WC, Papanicolaou GP, Perera MA, Cho MH, Liu DJ, Raffield LM, Li Y, TOPMed Multi-Omics Working Group, Wheeler HE, Im HK, Manichaikul A

Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populations.
(2026 Mar 18)
medRxiv
Chen HH, Cai Y, Graff M, Zhu W, Petty LE, Highland HM, Roshani R, Polikowsky HG, Lorenz AS, Frankel E, Landman JM, Anwar MY, Franson EE, Haessler J, Avery CL, Young KL, Fernandez-Rhodes L, Reiner AP, Peters U, Gordon-Larsen P, Gamazon ER, Pereira AC, Kooperberg C, Huff CD, Fisher-Hoch SP, McCormick JB, North KE, Below JE

An integrated germline and somatic genomic model for coronary artery disease.
(2026 Mar 26)
Nat Commun
Yang X, Kim MS, Zhu X, Uddin MM, Nakao T, Cho SMJ, Koyama S, Xu T, Reeskamp LF, Zhang R, Liu Z, A Y, de Vries PS, Vasan RS, Boerwinkle E, Morrison AC, Psaty BM, Tracy RP, Heckbert SR, Cho MH, Yun JH, Palmer ND, Bowden DW, Murabito JM, Levy D, Heard-Costa NL, O'Connor GT, Becker LC, Kral BG, Yanek LR, Raffield LM, Hidalgo B, Rotter JI, Rich SS, Taylor KD, Post WS, Kooperberg C, Reiner AP, Mitchell BD, Kardia SLR, Smith JA, Peyser PA, Bielak LF, Yon DK, Won HH, Arnett DK, Smith AV, Gabriel SB, Ellinor PT, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P, Wang M, Fahed AC

Plasma Proteins Associated With Psychosocial Factors and Heart Disease: The Jackson Heart Study.
(2026 May)
Arterioscler Thromb Vasc Biol 46(5): e324125
O'Brien SN, Gillman MG, Green MD, Cruz DE, Floyd JS, Hankinson S, Katz DH, Liu X, Odden MC, Psaty BM, Reiner AP, Rotter JI, Rich SS, Gerszten RE, Shah A, Sims M, Tahir UA, Tinker LF, Wood AC, Yu B, Zannas AS, Raffield LM, Glover LM

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