Faculty

Alexander Reiner

Research Professor, Epidemiology

206-667-2710

Education

MD Internal Medicine, Johns Hopkins University, 1984
MSc Epidemiology, University of Washington, 2001

Contact

206-667-2710

Fred Hutch Cancer Center
Box 358080
WHI Clinical Coordinating Ctr / Public Health Sciences
M3-A4
Seattle, WA

Research Interests

Genetic epidemiology of atherosclerotic, thrombotic and cardiovascular disease; population biology; genomics

Recent Publications (PubMed)

Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals.
(2025 Mar 6)
medRxiv
Zhao K, Pershad Y, Poisner HM, Ma X, Quade K, Vlasschaert C, Mack T, Khankari NK, von Beck K, Brogan J, Kishtagari A, Corty RW, Li Y, Xu Y, Reiner AP, Scheet P, Auer PL, Bick AG

Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure.
(2025 Mar 3)
bioRxiv
Latorre-Crespo E, Robertson NA, Kosebent EG, MacGillivray L, Murphy L, Uddin M, Whitsel E, Honigberg M, Bick A, Reiner AP, OrrĂ¹ V, Marongiu M, Cucca F, Fiorillo E, Deary IJ, Harris S, Cox S, Marioni R, Schumacher L, Chandra T, Kirschner K

Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures.
(2025 Feb 13)
Res Sq
Nicholas JC, Katz DH, Tahir UA, Debban CL, Aguet F, Blackwell T, Bowler RP, Broadaway KA, Chen J, Clish CB, Coresh J, Cornell E, Cruz DE, Deo R, Doyle MF, Durda P, Ekunwe L, Floyd JS, Gill D, Guo X, Hoogeveen RC, Johnson C, Lange LA, Li Y, Manning A, Meigs JB, Mi MY, Mychaleckyj JC, Olson NC, Pratte KA, Psaty BM, Reiner AP, Ruan P, Sevilla-Gonzalez M, Shah AM, Sun Q, Tracy RP, Wen J, Wood AC, Wilson JG, Young KL, Yu B, Rooney MR, Manichaikul A, Dubin R, Mohlke KL, Rich SS, Rotter JI, Ganz P, Gerszten RE, Taylor KD, Raffield LM

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
(2025 Feb)
Nat Comput Sci 5(2): 125-143
Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X

Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women.
(2025 Jan 13)
medRxiv
Pershad Y, Uddin MM, Xue L, Haessler J, Collins JM, Mack TM, Glick E, Glaser V, Zhao K, Jaiswal S, Manson JE, Pandey U, Desai P, Natarajan P, Honigberg MC, Kooperberg C, Whitsel EA, Kitzman JO, Bick AG, Reiner AP

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