Polly Newcomb

Research Professor, Epidemiology



PhD Epidemiology, University of Washington, 1986
MPH Epidemiology, University of Washington, 1982



Fred Hutchinson Cancer Research Center
Box 358080 (M4-B402)
1100 Fairview Avenue N., M4-B402
Seattle, WA 98109

Research Areas

Research Interests

My interests are the identification of modifiable risk factors for common cancers--colorectal, breast, and endometrium. Increasingly, my work has focused on better characterizing individuals at risk because of the joint presentation of environmental and genetic factors. Over the past 20 years, I have conducted several large population based case-control studies of cancer etiology. Cases enrolled in these studies now form the basis for cohorts to examine factors associated with survivorship. I am also interested in the observational evaluations of screening efficacy.

Recent Publications (PubMed)

A Risk Prediction Model to Identify Newborns at Risk for Missing Early Childhood Vaccinations.
(2021 Aug 17)
J Pediatric Infect Dis Soc
Oster NV, Williams EC, Unger JM, Newcomb PA, deHart MP, Englund JA, Hofstetter AM

Association Between Smoking and Molecular Subtypes of Colorectal Cancer.
(2021 Aug)
JNCI Cancer Spectr 5(4): pkab056
Wang X, Amitay E, Harrison TA, Banbury BL, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Gallinger SJ, Giannakis M, Giles GG, Gunter MJ, Hopper JL, Jenkins MA, Lin Y, Moreno V, Nishihara R, Newcomb PA, Ogino S, Phipps AI, Sakoda LC, Schoen RE, Slattery ML, Song M, Sun W, Thibodeau SN, Toland AE, Van Guelpen B, Woods MO, Hsu L, Hoffmeister M, Peters U

Association between post-treatment circulating biomarkers of inflammation and survival among stage II-III colorectal cancer patients.
(2021 Sep)
Br J Cancer 125(6): 806-815
Hua X, Kratz M, Malen RC, Dai JY, Lindström S, Zheng Y, Newcomb PA

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study.
(2021 Jun 28)
J Clin Med 10(13):
Dominguez-Valentin M, Plazzer JP, Sampson JR, Engel C, Aretz S, Jenkins MA, Sunde L, Bernstein I, Capella G, Balaguer F, Macrae F, Winship IM, Thomas H, Evans DG, Burn J, Greenblatt M, de Vos Tot Nederveen Cappel WH, Sijmons RH, Nielsen M, Bertario L, Bonanni B, Tibiletti MG, Cavestro GM, Lindblom A, Valle AD, Lopez-Kostner F, Alvarez K, Gluck N, Katz L, Heinimann K, Vaccaro CA, Nakken S, Hovig E, Green K, Lalloo F, Hill J, Vasen HFA, Perne C, Büttner R, Görgens H, Holinski-Feder E, Morak M, Holzapfel S, Hüneburg R, von Knebel Doeberitz M, Loeffler M, Rahner N, Weitz J, Steinke-Lange V, Schmiegel W, Vangala D, Crosbie EJ, Pineda M, Navarro M, Brunet J, Moreira L, Sánchez A, Serra-Burriel M, Mints M, Kariv R, Rosner G, Piñero TA, Pavicic WH, Kalfayan P, Broeke SWT, Mecklin JP, Pylvänäinen K, Renkonen-Sinisalo L, Lepistö A, Peltomäki P, Hopper JL, Win AK, Buchanan DD, Lindor NM, Gallinger S, Marchand LL, Newcomb PA, Figueiredo JC, Thibodeau SN, Therkildsen C, Hansen TVO, Lindberg L, Rødland EA, Neffa F, Esperon P, Tjandra D, Möslein G, Seppälä TT, Møller P

Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?
(2021 Sep)
Breast Cancer Res Treat 189(2): 463-470
Livingston-Rosanoff D, Trentham-Dietz A, Hampton JM, Newcomb PA, Wilke LG

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