Faculty

Kathleen E Malone

Research Professor, Epidemiology

206-667-4632

Education

PhD Epidemiology, University of Washington, 1993
MPH Epidemiology, Yale University, 1984
BSW Social Work, Temple University, 1978

Contact

206-667-4632

Fred Hutch Cancer Center
Box 358080 M4-C308
Division of Public Health Sciences
1100 Fairview Ave N, Arnold Building
PO Box 19024, Mailstop: M4-C308
Seattle, WA 98109

Bio

Dr. Malone is also the Head of the Program in Epidemiology at the Fred Hutchinson Cancer Research Center in Seattle, Washington.

Research Areas

Research Interests

My research focuses on breast cancer and involves three emphasis areas: etiology, genetics, and outcomes after breast cancer. Cancer survivorship has become a major focus and in this regard, I have conducted several population-based studies of the personal, lifestyle, medical, and tumor-based determinants of breast cancer recurrence and mortality. I have also led/co-led studies of second primary breast cancer in relation to treatment for the first primary, germline genetics and mammographic density. Currently, I am leading a new study of the molecular features of first and second primary breast cancers with dual foci on second primary risk prediction and the concordance of molecular features in paired tumors. We also have a current study examining risk factors for the four most common second primary cancers after breast cancer. Collectively, this research aims to develop tools for identifying those at high risk of adverse outcomes after breast cancer and to identify potential preventive strategies.

Recent Publications (PubMed)

Evaluating mammographic density polygenic risk score for contralateral breast cancer risk prediction.
(2026 Mar 4)
Sci Rep
Naderi E, Watt GP, Knight JA, Malone KE, Lynch CF, John EM, Shu X, Nguyen TL, Oh JH, Woods M, Liang X, Derkach A, Pike MC, Bernstein JL
Integrating genomic and non-genomic data to stratify the risk of contralateral breast cancer after radiotherapy.
(2026 Feb 26)
Int J Radiat Oncol Biol Phys
Lee S, Shu X, Derkach A, Reiner AS, Liang X, Woods M, Concannon P, Lynch CF, Malone KE, Knight JA, John EM, Deasy JO, Bernstein JL, Oh JH
Polygenic risk of coronary artery disease for long-term survivors of breast cancer.
(2025 Oct 1)
J Natl Cancer Inst 117(10): 2073-2081
Watt GP, Reiner AS, Shu X, Malone KE, Knight JA, John EM, Chow EJ, Lynch CF, Mellemkjær L, Woods M, Liang X, Tran AP, Oh JH, Derkach A, Bernstein JL
Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer.
(2024 Dec 2)
JAMA Netw Open 7(12): e2452158
Reiner AS, Watt GP, Malone KE, Lynch CF, John EM, Knight JA, Woods M, Liang X, Tischkowitz M, Conti DV, Robson ME, Mellemkjær L, Teraoka SN, Concannon P, Bernstein JL
Statin use after cancer diagnosis and survival among patients with cancer.
(2025 Apr)
Cancer Causes Control 36(4): 443-455
Guo H, Malone KE, Heckbert SR, Li CI
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