Faculty

Sara Lindstroem

Associate Professor, Epidemiology

206-221-3148
saralind@uw.edu

Education

MSc Engineering Physics, Umea University, 2004
PhD Genetic Epidemiology, Umea University, 2007

Contact

206-221-3148
saralind@uw.edu

University of Washington
Hans Rosling Population Health Building
3980 15th Ave NE
Box 351619, Seattle WA
Seattle, WA 98195
View Website »

Bio

Pronouns: she/her/hers

Dr. Lindstroem (Lindstrom/Lindström) is a genetic epidemiologist who seeks to understand the genetic contribution to complex disease with an emphasis on cancer. She works at the intersection of statistical genetics and genetic epidemiology, where she always seeks to apply novel statistical methods on large-scale -omics data. By leveraging large-scale population-based studies, she studies how our genes and environment affect our risk of developing disease. She leads multiple international efforts to study genetic risk factors for cancer and mammographic density (R01CA194393, R01CA244670), and she is studying the genetics underlying a range of outcomes in people living with HIV (R01DA047045). Dr. Lindstroem also teaches PHG511 “Genetic Epidemiology”, EPI583 “Epidemiology Seminars”, and co-teaches the “Genetic Epidemiology” module as part of the UW Summer Institute of Statistical Genetics (SISG).

Research Interests

My research focuses on understanding the genetic contribution to common complex diseases, with a primary emphasis on cancer and linked traits. By leveraging long-running large population-based studies, I investigate how our genetics and environment affect our risk of developing disease.

Current research projects include studying the shared genetic origin between common cancers and the genetics underlying childhood obesity, breast tissue composition and venous thromboembolism. I am also interested in finding approaches to incorporate information about the functional characteristics of the genome in my studies. Finally, I am involved in several large-scale international collaborations that study the genetics underlying breast and prostate cancer.

Recent Publications (PubMed)

Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation.
(2022 May 18)
Elife 11():
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, Houlston R, Kabrhel C, Papadimitriou N, Gunter M, Bull C, Bell JA, Vincent EE, Sattar N, Dunlop MG, Tomlinson IPM, Lindström S, INVENT consortium., Bell JD, Frayling T, Yaghootkar H

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women.
(2022 Apr 13)
Sci Rep 12(1): 6199
Wang X, Kapoor PM, Auer PL, Dennis J, Dunning AM, Wang Q, Lush M, Michailidou K, Bolla MK, Aronson KJ, Murphy RA, Brooks-Wilson A, Lee DG, Cordina-Duverger E, Guénel P, Truong T, Mulot C, Teras LR, Patel AV, Dossus L, Kaaks R, Hoppe R, Lo WY, Brüning T, Hamann U, Czene K, Gabrielson M, Hall P, Eriksson M, Jung A, Becher H, Couch FJ, Larson NL, Olson JE, Ruddy KJ, Giles GG, MacInnis RJ, Southey MC, Le Marchand L, Wilkens LR, Haiman CA, Olsson H, Augustinsson A, Krüger U, Wagner P, Scott C, Winham SJ, Vachon CM, Perou CM, Olshan AF, Troester MA, Hunter DJ, Eliassen HA, Tamimi RM, Brantley K, Andrulis IL, Figueroa J, Chanock SJ, Ahearn TU, García-Closas M, Evans GD, Newman WG, van Veen EM, Howell A, Wolk A, Håkansson N, Anton-Culver H, Ziogas A, Jones ME, Orr N, Schoemaker MJ, Swerdlow AJ, Kitahara CM, Linet M, Prentice RL, Easton DF, Milne RL, Kraft P, Chang-Claude J, Lindström S

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci.
(2022 Apr 12)
Breast Cancer Res 24(1): 27
Chen H, Fan S, Stone J, Thompson DJ, Douglas J, Li S, Scott C, Bolla MK, Wang Q, Dennis J, Michailidou K, Li C, Peters U, Hopper JL, Southey MC, Nguyen-Dumont T, Nguyen TL, Fasching PA, Behrens A, Cadby G, Murphy RA, Aronson K, Howell A, Astley S, Couch F, Olson J, Milne RL, Giles GG, Haiman CA, Maskarinec G, Winham S, John EM, Kurian A, Eliassen H, Andrulis I, Evans DG, Newman WG, Hall P, Czene K, Swerdlow A, Jones M, Pollan M, Fernandez-Navarro P, McConnell DS, Kristensen VN, NBCS Investigators., Rothstein JH, Wang P, Habel LA, Sieh W, Dunning AM, Pharoah PDP, Easton DF, Gierach GL, Tamimi RM, Vachon CM, Lindström S

Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal Women.
(2022 Apr 1)
Endocrinology 163(4):
Haas CB, Hsu L, Lampe JW, Wernli KJ, Lindström S

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation.
(2022 Jan 25)
Elife 11():
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, Houlston R, Kabrhel C, Papadimitriou N, Gunter MJ, Bull CJ, Bell JA, Vincent EE, Sattar N, Dunlop MG, Tomlinson IPM, Lindström S, INVENT consortium., Bell JD, Frayling TM, Yaghootkar H

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