Faculty

Sara Lindstroem

Associate Professor, Epidemiology

206-221-3148
saralind@uw.edu

Education

MSc Engineering Physics, Umea University, 2004
PhD Genetic Epidemiology, Umea University, 2007

Contact

206-221-3148
saralind@uw.edu

University of Washington
Hans Rosling Population Health Building
3980 15th Ave NE
Box 351619, Seattle WA
Seattle, WA 98195

Bio

Pronouns: she/her/hers

Dr. Lindstroem (Lindstrom/Lindström) is a genetic epidemiologist who seeks to understand the genetic contribution to complex disease with an emphasis on cancer. She works at the intersection of statistical genetics and genetic epidemiology, where she always seeks to apply novel statistical methods on large-scale -omics data. By leveraging large-scale population-based studies, she studies how our genes and environment affect our risk of developing disease. She leads multiple international efforts to study genetic risk factors for cancer and mammographic density (R01CA194393, R01CA244670), and she is studying the genetics underlying a range of outcomes in people living with HIV (R01DA047045). Dr. Lindstroem also teaches PHG511 “Genetic Epidemiology”, EPI583 “Epidemiology Seminars”, and co-teaches the “Genetic Epidemiology” module as part of the UW Summer Institute of Statistical Genetics (SISG).

Research Interests

My research focuses on understanding the genetic contribution to common complex diseases, with a primary emphasis on cancer and linked traits. By leveraging long-running large population-based studies, I investigate how our genetics and environment affect our risk of developing disease.

Current research projects include studying the shared genetic origin between common cancers and the genetics underlying childhood obesity, breast tissue composition and venous thromboembolism. I am also interested in finding approaches to incorporate information about the functional characteristics of the genome in my studies. Finally, I am involved in several large-scale international collaborations that study the genetics underlying breast and prostate cancer.

Recent Publications (PubMed)

Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals.
(2021 Jul 8)
HGG Adv 2(3):
Chen H, Majumdar A, Wang L, Kar S, Brown KM, Feng H, Turman C, Dennis J, Easton D, Michailidou K, Simard J, Breast Cancer Association Consortium (BCAC)., Bishop T, Cheng IC, Huyghe JR, Schmit SL, Colorectal Transdisciplinary Study (CORECT)., Colon Cancer Family Registry Study (CCFR)., Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)., O'Mara TA, Spurdle AB, Endometrial Cancer Association Consortium (ECAC)., Gharahkhani P, Schumacher J, Jankowski J, Gocke I, Esophageal Cancer GWAS Consortium., Bondy ML, Houlston RS, Jenkins RB, Melin B, Glioma International Case Control Consortium (GICC)., Lesseur C, Ness AR, Diergaarde B, Olshan AF, Head-Neck Cancer GWAS Consortium., Amos CI, Christiani DC, Landi MT, McKay JD, International Lung Cancer Consortium (ILCCO)., Brossard M, Iles MM, Law MH, MacGregor S, Melanoma GWAS Consortium., Beesley J, Jones MR, Tyrer J, Winham SJ, Ovarian Cancer Association Consortium (OCAC)., Klein AP, Petersen G, Li D, Wolpin BM, Pancreatic Cancer Case-Control Consortium (PANC4)., Pancreatic Cancer Cohort Consortium (PanScan)., Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR, PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS., Brennan P, Chanock SJ, Gaborieau V, Purdue MP, Renal Cancer GWAS Consortium., Pharoah P, Hung RJ, Amundadottir LT, Kraft P, Pasaniuc B, Lindström S

Genetic insights into biological mechanisms governing human ovarian ageing.
(2021 Aug)
Nature 596(7872): 393-397
Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, Huang Y, Stankovic S, Timmers PRHJ, Ahearn TU, Alizadeh BZ, Naderi E, Andrulis IL, Arnold AM, Aronson KJ, Augustinsson A, Bandinelli S, Barbieri CM, Beaumont RN, Becher H, Beckmann MW, Benonisdottir S, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Boomsma DI, Bowker N, Brody JA, Broer L, Buring JE, Campbell A, Campbell H, Castelao JE, Catamo E, Chanock SJ, Chenevix-Trench G, Ciullo M, Corre T, Couch FJ, Cox A, Crisponi L, Cross SS, Cucca F, Czene K, Smith GD, de Geus EJCN, de Mutsert R, De Vivo I, Demerath EW, Dennis J, Dunning AM, Dwek M, Eriksson M, Esko T, Fasching PA, Faul JD, Ferrucci L, Franceschini N, Frayling TM, Gago-Dominguez M, Mezzavilla M, García-Closas M, Gieger C, Giles GG, Grallert H, Gudbjartsson DF, Gudnason V, Guénel P, Haiman CA, Håkansson N, Hall P, Hayward C, He C, He W, Heiss G, Høffding MK, Hopper JL, Hottenga JJ, Hu F, Hunter D, Ikram MA, Jackson RD, Joaquim MDR, John EM, Joshi PK, Karasik D, Kardia SLR, Kartsonaki C, Karlsson R, Kitahara CM, Kolcic I, Kooperberg C, Kraft P, Kurian AW, Kutalik Z, La Bianca M, LaChance G, Langenberg C, Launer LJ, Laven JSE, Lawlor DA, Le Marchand L, Li J, Lindblom A, Lindstrom S, Lindstrom T, Linet M, Liu Y, Liu S, Luan J, Mägi R, Magnusson PKE, Mangino M, Mannermaa A, Marco B, Marten J, Martin NG, Mbarek H, McKnight B, Medland SE, Meisinger C, Meitinger T, Menni C, Metspalu A, Milani L, Milne RL, Montgomery GW, Mook-Kanamori DO, Mulas A, Mulligan AM, Murray A, Nalls MA, Newman A, Noordam R, Nutile T, Nyholt DR, Olshan AF, Olsson H, Painter JN, Patel AV, Pedersen NL, Perjakova N, Peters A, Peters U, Pharoah PDP, Polasek O, Porcu E, Psaty BM, Rahman I, Rennert G, Rennert HS, Ridker PM, Ring SM, Robino A, Rose LM, Rosendaal FR, Rossouw J, Rudan I, Rueedi R, Ruggiero D, Sala CF, Saloustros E, Sandler DP, Sanna S, Sawyer EJ, Sarnowski C, Schlessinger D, Schmidt MK, Schoemaker MJ, Schraut KE, Scott C, Shekari S, Shrikhande A, Smith AV, Smith BH, Smith JA, Sorice R, Southey MC, Spector TD, Spinelli JJ, Stampfer M, Stöckl D, van Meurs JBJ, Strauch K, Styrkarsdottir U, Swerdlow AJ, Tanaka T, Teras LR, Teumer A, Þorsteinsdottir U, Timpson NJ, Toniolo D, Traglia M, Troester MA, Truong T, Tyrrell J, Uitterlinden AG, Ulivi S, Vachon CM, Vitart V, Völker U, Vollenweider P, Völzke H, Wang Q, Wareham NJ, Weinberg CR, Weir DR, Wilcox AN, van Dijk KW, Willemsen G, Wilson JF, Wolffenbuttel BHR, Wolk A, Wood AR, Zhao W, Zygmunt M, Biobank-based Integrative Omics Study (BIOS) Consortium., eQTLGen Consortium., Biobank Japan Project., China Kadoorie Biobank Collaborative Group., kConFab Investigators., LifeLines Cohort Study., InterAct consortium., 23andMe Research Team., Chen Z, Li L, Franke L, Burgess S, Deelen P, Pers TH, Grøndahl ML, Andersen CY, Pujol A, Lopez-Contreras AJ, Daniel JA, Stefansson K, Chang-Claude J, van der Schouw YT, Lunetta KL, Chasman DI, Easton DF, Visser JA, Ozanne SE, Namekawa SH, Solc P, Murabito JM, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.
(2021 Jul 22)
J Clin Oncol
Boddicker NJ, Hu C, Weitzel JN, Kraft P, Nathanson KL, Goldgar DE, Na J, Huang H, Gnanaolivu RD, Larson N, Yussuf A, Yao S, Vachon CM, Trentham-Dietz A, Teras L, Taylor JA, Scott CE, Sandler DP, Pesaran T, Patel AV, Palmer JR, Ong IM, Olson JE, O'Brien K, Neuhausen S, Martinez E, Ma H, Lindstrom S, Le Marchand L, Kooperberg C, Karam R, Hunter DJ, Hodge JM, Haiman C, Gaudet MM, Gao C, LaDuca H, Lacey JV, Dolinsky JS, Chao E, Carter BD, Burnside ES, Bertrand KA, Bernstein L, Auer PW, Ambrosone C, Yadav S, Hart SN, Polley EC, Domchek SM, Couch FJ

Association between post-treatment circulating biomarkers of inflammation and survival among stage II-III colorectal cancer patients.
(2021 Sep)
Br J Cancer 125(6): 806-815
Hua X, Kratz M, Malen RC, Dai JY, Lindström S, Zheng Y, Newcomb PA

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score.
(2021 Aug 10)
J Clin Oncol 39(23): 2564-2573
Gao C, Polley EC, Hart SN, Huang H, Hu C, Gnanaolivu R, Lilyquist J, Boddicker NJ, Na J, Ambrosone CB, Auer PL, Bernstein L, Burnside ES, Eliassen AH, Gaudet MM, Haiman C, Hunter DJ, Jacobs EJ, John EM, Lindström S, Ma H, Neuhausen SL, Newcomb PA, O'Brien KM, Olson JE, Ong IM, Patel AV, Palmer JR, Sandler DP, Tamimi R, Taylor JA, Teras LR, Trentham-Dietz A, Vachon CM, Weinberg CR, Yao S, Weitzel JN, Goldgar DE, Domchek SM, Nathanson KL, Couch FJ, Kraft P

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