Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease.
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Clin Epigenetics
Ma J, Lai CQ, Li XS, Wang M, Wang Z, Yao J, Guo X, Taylor KD, Lee S, Tracy RP, Peter D, Liu Y, Rotter JI, Rich SS, Budoff M, Tang W, DiDonato JA, Brody JA, Lemaitre RN, Fretts A, Sotoodehnia N, Psaty BM, Ordovás JM, Siscovick DS, Hazen SL, Mozaffarian D

Association of Sphingolipids with All-Cause and Cardiovascular Death in Patients with Kidney Failure Treated with Maintenance Hemodialysis.
(2025 Dec 19)
J Am Soc Nephrol
Lidgard B, Hoofnagle AN, Zelnick LR, de Boer IH, Jensen P, Fretts AM, Siscovick DS, Umans JG, Bansal N, Lemaitre RN

Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes.
(2026 Jan 14)
Nat Med
Li J, Hu J, Yun H, Mei Z, Wang X, Luo K, Guasch-Ferré M, Han X, Truong B, Merino J, Jia C, Ruiz-Canela M, Rebholz CM, Moon EH, Alkis T, Liu G, Yao J, Zhang X, Porneala BC, Salas-Salvadó J, Wang TJ, Dupuis J, Selvin E, Guo X, Bhupathiraju SN, Brody JA, Liu Y, Wood AC, North KE, Jung SY, Liu CT, Sotoodehnia N, Liu S, Tinker LF, Eliassen AH, Manson JE, Florez JC, Gerszten RE, Clish CB, Liang L, Lemaitre RN, Tucker KL, Rich SS, Rotter JI, Martínez-González MA, Rexrode KM, Meigs JB, Boerwinkle E, Kaplan RC, Hu FB, Yu B, Qi Q

Fibrinogen-associated plasma metabolites and implications for coagulation, inflammation, and vascular diseases.
(2026 Jan 8)
J Thromb Haemost
Nicholas JC, Alkis T, Bis JC, Boerwinkle E, Brody JA, Clish CB, de Vries PS, Gao Y, Gerzsten RE, Guo X, Johnson AD, Larson MG, Lemaitre RN, Psaty BM, Vasan RS, Reiner AP, Rich SS, Rodriguez B, Rong J, Rotter JI, Simino J, Smith NL, Wilson J, Yao J, Morrison AC, Yu B, Raffield LM

The Associations of Circulating Sphingolipid Levels with Future Loss of Vibration and Light Pressure Sensation in the Lower Limb.
(2025 Dec 6)
Biomedicines 13(12):
Barzilay JI, Bartz TM, Longstreth WT Jr, Strotmeyer ES, Hoofnagle AN, Siscovick D, Mukamal KJ, Lemaitre RN