Sylvia Lacourse

Adjunct Assistant Professor, Epidemiology
Assistant Professor, Medicine - Allergy and Infectious Dis.
Assistant Professor, Global Health



MD University of Louisville, 2007
BA Environmental Science, University of California (Santa Barbara), 1995



Box 359931
325 9th Avenue
Seattle, WA 98104


Dr. LaCourse’s research focuses on improved tuberculosis prevention, screening, and detection with a focus on people with HIV, including pregnant people and children. She leads clinical cohorts of pregnant people and children evaluating diagnostics for latent and active TB infection as well as interventional studies evaluating TB prevention therapy including among HIV-exposed uninfected children and pregnant people with HIV. Active areas of research include evaluation of non-sputum based TB diagnostics as well as the role of pregnancy and HIV in TB susceptibility. An additional area of scientific focus is SAR-CoV-2 antibody responses in pregnant people and their infants.

Dr. LaCourse is a GWACh (Global Women, Adolescent, and Child health) scientific lead, Kenya Research and Training Center (KRTC) faculty member, Tuberculosis Research & Training Center (TRTC) leadership committee member, and TB ECHO (Extension for Community Healthcare Outcomes) faculty, and co-leads the Development core of the recently awarded NIH Seattle TB Research Advancement Center (SEA-TRAC). She is committed to the inclusion of children and pregnant women in HIV/TB research as an IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials Network) TB Scientific Committee mentored junior investigator, and International Union Against TB and Lung Disease Maternal Child Health Working Group Scientific Co-Lead.

She is an attending physician at the Madison HIV clinic and infectious diseases, general medicine, and HIV inpatient services at the University of Washington and Harborview Medical Centers.

Recent Publications (PubMed)

Performance of Tuberculosis symptom screening among hospitalized ART-naïve Children with HIV in Kenya.
(2022 Sep 26)
J Acquir Immune Defic Syndr
Cranmer LM, Njuguna IN, LaCourse SM, Figueroa J, Gillespie S, Maleche-Obimbo E, Otieno V, Mugo C, Okinyi H, Benki-Nugent S, Pavlinac PB, Malik AA, Gandhi NR, Richardson BA, Stern J, Wamalwa DC, John-Stewart GC

Report: A pox presenting without pox.
(2022 Sep 8)
Sex Transm Dis
Karmarkar E, Altwies E, Desta R, Ahmed AM, Nick E, Gozo MAR, Cogen AL, Uribe G, Disharoon S, Liles WC, LaCourse SM

Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples.
(2022 Aug)
Nat Biomed Eng 6(8): 979-991
Zheng W, LaCourse SM, Song B, Singh DK, Khanna M, Olivo J, Stern J, Escudero JN, Vergara C, Zhang F, Li S, Wang S, Cranmer LM, Huang Z, Bojanowski CM, Bao D, Njuguna I, Xiao Y, Wamalwa DC, Nguyen DT, Yang L, Maleche-Obimbo E, Nguyen N, Zhang L, Phan H, Fan J, Ning B, Li C, Lyon CJ, Graviss EA, John-Stewart G, Mitchell CD, Ramsay AJ, Kaushal D, Liang R, Pérez-Then E, Hu TY

Drop-offs in the isoniazid preventive therapy cascade among children living with HIV in western Kenya, 2015-2019.
(2022 Aug)
J Int AIDS Soc 25(8): e25939
Onyango DO, van der Sande MAB, Yuen CM, Mecha J, Matemo D, Oele E, Kinuthia J, John-Stewart G, LaCourse SM

Promoting tuberculosis preventive therapy in HIV.
(2022 Sep)
Lancet HIV 9(9): e596-e597
LaCourse SM, Onyango D

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