Faculty

Mandy Fretts

Associate Professor, Epidemiology


Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact


University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Recruitment strategies for a randomized controlled trial in a rural American Indian community: the Cooking for Health Study.
(2026 Jun 27)
Trials
Green SA, O'Leary R, Huber CM, Thorndike AN, Best LG, Brown MC, O'Leary M, Umans J, Hager A, Whitebull R, Beresford S, Fretts AM

Vitamin D Deficiency and Markers of Liver Disease in American Indian Adolescents: The Strong Heart Family Study (SHFS).
(2026 Jun 3)
Biomedicines 14(6):
Reese JA, Davis E, Holloway P, Fretts AM, Ali T, Lee ET, Umans JG, Deen JF, Middleton MS, Loomba R, Sirlin CB, Cole SA, Zhang Y, Peck JD

Plasma Proteins Associated with Whole Grains and Fiber Intake in the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study.
(2026 Jun 2)
J Nutr
Feinberg A, Austin TR, Vasconcelos AG, Brody JA, Wiggins KL, Lemaitre RN, Fretts AM, Hasson DC, Sotoodehnia N, Floyd JS, Rebholz CM, Psaty BM, Kim H

Associations of Pregnancy History and Complications with Cardiovascular Disease Among American Indian Women: The Strong Heart Family Study.
(2026 Jun 2)
J Womens Health (Larchmt)
Ebadani L, Reese JA, Sitlani CM, Best LG, Umans JG, Zhang Y, Enquobahrie DA, Fretts AM

Lipidomic Markers of Tobacco Use and Cessation Associated With Cardiovascular Risk Factors: A Longitudinal Study in American Indian Individuals.
(2026 May 19)
J Am Heart Assoc 15(10): e046020
Wen X, Miao G, Chen M, Zhang Y, Fretts AM, Fiehn O, Zhao J

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