Faculty

Mandy Fretts

Associate Professor, Epidemiology

206-543-9236

Education

PhD Epidemiology, University of Washington, 2011
MPH Epidemiology, University of Washington, 2007

Contact

206-543-9236

University of Washington
Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 873
Seattle, WA 98195

Bio

Dr. Fretts is a cardiovascular and nutritional epidemiologist with a focus on observational and interventional research aimed at improving cardio-metabolic health in underserved and rural communities (with a focus on American Indian communities). Her work aims to work with community partners to integrate observational and interventional research to mitigate obesity-related health disparities and improve health behaviors and health outcomes. Dr. Fretts’ research primarily focuses on nutrition, food insecurity, the food environment, physical activity, obesity, fatty acids, and diabetes. She is the Principal Investigator of the Dakotas field site for the Strong Heart Study, a large cohort study of heart disease and its risk factors in 12 American Indian communities in Arizona, Oklahoma, North Dakota and South Dakota, that has been on-going since 1988. She is also Principal Investigator of a community-based diet and cooking skills intervention (randomized trial) designed to improve blood sugar control and other cardiovascular risk factors for American Indians with type 2 diabetes. In addition to her work with American Indian communities, she is involved in several on-going projects related to fatty acids, diet, diet*gene interactions, diabetes, and cardiovascular outcomes in the Cardiovascular Health Study and the Fatty Acids and Outcomes Research Consortium (FORCE) consortium.

Research Interests

  • American Indian health
  • Diabetes
  • Interventions
  • Nutrition
  • Physical activity
  • Lifestyle
  • Social epidemiology
  • Health disparities
  • Obesity
  • Fatty acids
  • Cardio-metabolic disease prevention

Recent Publications (PubMed)

Systemic interventions towards kidney health equity in American Indian and Alaska Native communities.
(2025 Mar 6)
Nat Rev Nephrol
Mokiao RH, Deen JF, Fretts AM, Young BA

A Large-Scale Genome-wide Association Study of Blood Pressure Accounting for Gene-Depressive Symptomatology Interactions in 564,680 Individuals from Diverse Populations.
(2025 Feb 17)
Res Sq
Lee S, Miller CL, Bentley AR, Brown MR, Nagarajan P, Noordam R, Morrison J, Schwander K, Westerman K, Kho M, Kraja AT, de Vries PS, Ammous F, Aschard H, Bartz TM, Do A, Dupont CT, Feitosa MF, Gudmundsdottir V, Guo X, Harris SE, Hikino K, Huang Z, Lefevre C, Lyytikäinen LP, Milaneschi Y, Nardone GG, Santin A, Schmidt H, Shen B, Sofer T, Sun Q, Tan YA, Tang J, Thériault S, van der Most PJ, Ware EB, Weiss S, Xing WY, Yu C, Zhao W, Ansari MAY, Anugu P, Attia JR, Bazzano LA, Bis JC, Breyer M, Cade B, Chen G, Collins S, Corley J, Davies G, Dörr M, Du J, Edwards TL, Faquih T, Faul JD, Fohner AE, Fretts AM, Gangireddy S, Gepner A, Graff M, Hofer E, Homuth G, Hood MM, Jie X, Kähönen M, Kardia SL, Karvonen-Gutierrez CA, Launer LJ, Levy D, Maheshwari M, Martin LW, Matsuda K, McNeil JJ, Nolte IM, Okochi T, Raffield LM, Raitakari OT, Risch L, Risch M, Roux AD, Ruiz-Narvaez EA, Russ TC, Saito T, Schreiner PJ, Scott RJ, Shikany J, Smith JA, Snieder H, Spedicati B, Tai ES, Taylor AM, Taylor KD, Tesolin P, van Dam RM, Wang R, Wenbin W, Xie T, Yao J, Young KL, Zhang R, Zonderman AB, Project TBJ, Study LC, Concas MP, Conen D, Cox SR, Evans MK, Fox ER, Fuentes LL, Giri A, Girotto G, Grabe HJ, Gu C, Gudnason V, Harlow SD, Holliday E, Jost JB, Lacaze P, Lee S, Lehtimäki T, Li C, Liu CT, Morrison AC, North KE, Penninx BW, Peyser PA, Province MM, Psaty BM, Redline S, Rosendaal FR, Rotimi CN, Rotter JI, Schmidt R, Sim X, Terao C, Weir DR, Zhu X, Franceschini N, O'Connell JR, Jaquish CE, Wang H, Manning A, Munroe PB, Rao DC, Chen H, Gauderman WJ, Bierut L, Winkler TW, Fornage M

Content analysis of factors related to sleep health among American Indian peoples.
(2025 Feb 26)
Sleep Health
King R, Koch S, Burns R, Cupp C, Lindell M, London S, Bunch J, Fretts A, Ali T, Umans J, Nelson L

High-Density Lipoprotein Lipidomics, Endothelial Dysfunction, and Fistula Maturation in Patients With Advanced Chronic Kidney Disease.
(2025 Mar)
Kidney Med 7(3): 100954
Lidgard B, Hoofnagle AN, Zelnick LR, de Boer IH, Fretts AM, Kestenbaum BR, Lemaitre RN, Robinson-Cohen C, Bansal N

Depression and Incident Hypertension: The Strong Heart Family Study.
(2025 Jan 16)
Prev Chronic Dis 22(): E06
Santoni S, Kernic MA, Malloy K, Ali T, Zhang Y, Cole SA, Fretts AM

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