Ann C Duerr

Affiliate Professor, Epidemiology
Affiliate Professor, Global Health



PhD Biochemistry, Cell Biology, Massachusetts Institute of Technology, 1981
MD Medicine, Harvard University, 1985
MPH Epidemiology, Johns Hopkins University, 1988



Fred Hutchinson Cancer Research Center
Office E2-112
Box 358080
HIV Vaccine Trials Network
1100 Fairview Ave N
Seattle, WA 98109
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My current research focuses on early HIV detection and treatment to prevent onward HIV transmission among MSM in Peru and on multiple collaborations with laboratory scientists to study the implication of early treatment and substance use for future HIV cure strategies.
I hold appointments in Vaccine and Infectious Diseases, Clinical Research, and Public Health Sciences at the FHCRC and as an Affiliate Professor in the Departments of Epidemiology and Global Health at the University of Washington. I am Director of the Global Health Program of the Strategic Analysis Research and Training (START) Center. This collaborative program between the University of Washington and the Bill & Melinda Gates Foundation (BMGF) pairs graduate students with faculty mentors to provide applied experience for students and an academic-level research resource for the foundation. I also serve as an advisor to Ambassador Deborah Birx in the Office of the U.S. Global AIDS Coordinator and Health Diplomacy (OGAC) on the DREAMS Initiative, a partnership of OGAC with the BMGF and the Nike Foundation intended to reduce new HIV infections in girls and young women in 10 sub-Saharan countries.

Research Areas

Research Interests

Throughout her career, Dr. Duerr has been interested in public health issues of resource-limited settings, with a special emphasis on HIV and women's health. She trained in laboratory science, medicine, and infectious disease epidemiology - she received a B.Sc. degree from McGill University, a Ph.D. from Massachusetts Institute of Technology, an M.D. from Harvard University and an M.P.H. from Johns Hopkins University. For over 20 years, her research has focused on HIV. Her initial epidemiologic research focused on parameters associated with HIV transmission from women to infants in Rwanda and on fully characterizing the clinical course of HIV infections in US women. More recently, her work has been focused on prevention – specifically, on an intervention among African women to prevent mother-to-child HIV transmission via breastfeeding and on trials of prophylactic HIV vaccines as Director for Scientific Affairs of the HIV Vaccine Trials Network (HVTN). The HVTN is an international partnership of researchers with 25 sites on 4 continents conducting studies of the safety, immunogenicity, and efficacy studies of HIV vaccine candidates. She has also conducted research in non-human primates investigating ways to increase vaccine-induced immunity at mucosal surfaces, the site of infection for most pathogens.  She has a long-standing interest in clinical trials and is currently working on studies of antiretroviral treatment to prevent onward HIV transmission in Peru.  Her work in Peru also involves investigations of the impact of initiation of antiretroviral therapy (ART) during early HIV infection, including effects on neurological outcomes and implications for HIV cure strategies.

Recent Publications (PubMed)

Viral load dynamics in plasma and semen when ART is initiated during early HIV-1 infection.
(2023 Nov 24)
J Infect Dis
Gilada T, Ulrich AK, Wang Y, Lama JR, Alfaro R, Harb S, Daza G, Holte S, Pasalar S, Rios J, Ganoza C, Dasgupta S, Coombs RW, Duerr A

Impact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program.
PLoS One 18(11): e0294719
Tollefson D, Dasgupta S, Setswe G, Reeves S, Charalambous S, Duerr A

Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.
(2023 Nov 14)
Immunity 56(11): 2584-2601.e7
Wei Y, Davenport TC, Collora JA, Ma HK, Pinto-Santini D, Lama J, Alfaro R, Duerr A, Ho YC

Protocol for evaluating mechanistic pathways associated with HIV acquisition via nested Least Absolute Shrinkage and Selective Operator analysis.
(2023 Oct 3)
STAR Protoc 4(4): 102628
Dasgupta S, Ulrich AK, Duerr A, Bender Ignacio RA

A Quantitative Intersectionality Analysis of HIV/STI Prevention and Healthcare Access Among Transgender and Nonbinary People.
(2023 Nov 1)
Epidemiology 34(6): 827-837
Tordoff DM, Fernandez A, Perry NL, Heberling WB, Minalga B, Khosropour CM, Glick SN, Barbee LA, Duerr A, Seattle Trans and Non-binary Sexual Health (STARS) Advisory Board

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