Faculty

Burcu Darst

Affiliate Assistant Professor, Epidemiology

206-667-1036

Education

PhD Epidemiology, University of Wisconsin (Madison), 2018
BS Cognitive Science, University of California (San Diego), 2009

Contact

206-667-1036

Office M4-B873
1100 Fairview Ave N
Seattle, WA 98109
View Website »

Bio

Dr. Burcu Darst’s is a genetic epidemiologist with research focused on identifying and understanding genetic and multi-omic risk factors of complex diseases in diverse populations, particularly how they relate to health disparities. Her research lies predominantly in studying prostate cancer, type 2 diabetes, and Alzheimer’s disease, with the underlying goal of identifying risk factors that could prevent the onset and health disparities of these diseases. Dr. Darst’s research is based on a variety of approaches, including using rare genetic variants captured with genomic sequencing, genome-wide association studies, polygenic risk scores, and metabolomics to understand disease risk. Currently, she is leading an effort to improve understanding of the genomic and metabolic mechanisms contributing to prostate cancer risk in men from diverse populations as well as improving the utility of polygenic risk scores and rare genetic variants for the prediction of prostate cancer across multi-ancestry patient populations.This research is conducted in collaboration with large-scale international collaborations investigating genetic risk of prostate cancer.

Research Interests

Prostate cancer prevention, Health disparities, Genetic risk factors, Molecular biomarkers, Multi-omic integration

Recent Publications (PubMed)

Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease.
(2025 Oct 6)
Genome Med 17(1): 113
Kim D, Highland HM, Smit RAJ, Hysong MR, Buchanan VL, Young KL, Zhao C, Spracklen CN, Kilpeläinen TO, Guo B, Darst BF, Cai Y, Wang Z, Lundin J, Berndt SI, Manson JE, Marouli E, Lange L, Lange E, Fornage M, Gignoux CR, Haiman CA, Rich SS, Buyske S, Loos RJF, Kooperberg C, Peters U, Avery CL, Gordon-Larsen P, Graff M, Raffield LM, North KE

Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
(2025 Oct 1)
Nat Commun 16(1): 8632
Guo B, Cai Y, Kim D, Smit RAJ, Wang Z, Iyer KR, Hilliard AT, Haessler J, Tao R, Broadaway KA, Wang Y, Pozdeyev N, Stæger FF, Yang C, Vanderwerff B, Patki AD, Stalbow L, Lin M, Rafaels N, Shortt J, Wiley L, Stanislawski M, Pattee J, Davis L, Straub PS, Shuey MM, Cox NJ, Lee NR, Jørgensen ME, Bjerregaard P, Larsen C, Hansen T, Moltke I, Meigs JB, Stram DO, Yin X, Zhou X, Chang KM, Clarke SL, Guarischi-Sousa R, Lankester J, Tsao PS, Buyske S, Graff M, Raffield LM, Sun Q, Wilkens LR, Carlson CS, Easton CB, Liu S, Manson JE, Marchand LL, Haiman CA, Mohlke KL, Gordon-Larsen P, Albrechtsen A, Boehnke M, Rich SS, Manichaikul A, Rotter JI, Yousri NA, Irvin RM, biobank at the Colorado Center for Personalized Medicine (CCPM), VA Million Veteran Program (MVP), Gignoux C, North KE, Loos RJF, Assimes TL, Peters U, Kooperberg C, Raghavan S, Highland HM, Darst BF

Gene-Diet Interaction Analysis in UK Biobank Identified Genetic Loci That Modify the Association Between Fish Oil Supplementation and the Incidence of Dementia.
(2025 Sep)
Curr Dev Nutr 9(9): 107524
Lu Y, Xu H, Sun Y, Ihejirika SA, Chiang CW, Darst BF, Song S, Shen Y, Ye K

Patient and Physician Perceptions of Prostate-Specific Antigen Testing Among Black Individuals.
(2025 Sep 2)
JAMA Netw Open 8(9): e2530946
Lee JR, Morehead D, Young B, Tolbert V, Masembe J, Britt G, Neuenschwander L, Schuppe K, Pelman R, Johnson D, Henderson V, Darst BF, Egwuatu P, Kim SM, Wolff EM, Gore JL, Nyame YA

Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African Ancestry.
(2025 Sep 9)
Neurology 105(5): e213976
Wang L, Xu H, Simons RL, Beach SRH, Lei MK, Ong ML, Philibert RA, Mielke MM, Sun Y, Lu Y, Chiang CWK, Darst BF, Ye K

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