Helen Y Chu

Professor, Epidemiology
Professor, Medicine - Allergy and Infectious Dis.
Adjunct Professor, Global Health
Term Professorship, Medicine - Allergy and Infectious Dis.


MPH Epidemiology, University of Washington, 2012
MD Medicine, Duke University Medical Center, Durham, NC, 2005
BA Cornell University, 2001

Research Interests

Dr. Chu's research is focused on maternal immunization, in particular vaccines against influenza and respiratory syncytial virus (RSV). She studies the virologic and immunologic correlates of protection from respiratory viral infections in pregnant women, infants, and older adults, and performs clinical trials of vaccine candidates in both domestic and international sites, including Nepal and Bangladesh. She has developed immunologic assays to study transplacental transfer and decay kinetics of RSV antibody, and nosocomial and household transmission of respiratory viruses by genotypic analysis and molecular sequencing.

Recent Publications (PubMed)

Comparative diagnostic utility of SARS-CoV-2 rapid antigen and molecular testing in a community setting.
(2024 Mar 26)
J Infect Dis
Kim AE, Bennett JC, Luiten K, O'Hanlon JA, Wolf CR, Magedson A, Han PD, Acker Z, Regelbrugge L, McCaffrey KM, Stone J, Reinhart D, Capodanno BJ, Morse SS, Bedford T, Englund JA, Boeckh M, Starita LM, Uyeki TM, Carone M, Weil A, Chu HY

Local-scale phylodynamics reveal differential community impact of SARS-CoV-2 in a metropolitan US county.
(2024 Mar)
PLoS Pathog 20(3): e1012117
Paredes MI, Perofsky AC, Frisbie L, Moncla LH, Roychoudhury P, Xie H, Bakhash SAM, Kong K, Arnould I, Nguyen TV, Wendm ST, Hajian P, Ellis S, Mathias PC, Greninger AL, Starita LM, Frazar CD, Ryke E, Zhong W, Gamboa L, Threlkeld M, Lee J, Stone J, McDermot E, Truong M, Shendure J, Oltean HN, Viboud C, Chu H, Müller NF, Bedford T

Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans.
(2024 Apr 9)
Immunity 57(4): 904-911.e4
Tortorici MA, Addetia A, Seo AJ, Brown J, Sprouse K, Logue J, Clark E, Franko N, Chu H, Veesler D

Remote surveillance and detection of SARS-CoV-2 transmission among household members in King County, Washington.
(2024 Mar 13)
BMC Infect Dis 24(1): 309
Emanuels A, Casto AM, Heimonen J, O'Hanlon J, Chow EJ, Ogokeh C, Rolfes MA, Han PD, Hughes JP, Uyeki TM, Frazar C, Chung E, Starita LM, Englund JA, Chu HY, Seattle Flu Study Investigators

Reopening schools safely and educating youth (ROSSEY) study: Protocol for a community-based, cluster randomized controlled trial.
(2024 Apr)
Contemp Clin Trials 139(): 107480
Ramirez M, Shah PD, Chu HY, Garza L, Linde S, Garrison MM, Zhou C, Bishop S, Ibarra G, Ko LK

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