Faculty

Helen Y Chu

Professor, Epidemiology
Professor, Medicine - Allergy and Infectious Dis.
Adjunct Professor, Global Health
Term Professorship, Medicine - Allergy and Infectious Dis.


Education

MPH Epidemiology, University of Washington, 2012
MD Medicine, Duke University Medical Center, Durham, NC, 2005
BA Cornell University, 2001

Research Areas

Research Interests

Dr. Chu's research is focused on maternal immunization, in particular vaccines against influenza and respiratory syncytial virus (RSV). She studies the virologic and immunologic correlates of protection from respiratory viral infections in pregnant women, infants, and older adults, and performs clinical trials of vaccine candidates in both domestic and international sites, including Nepal and Bangladesh. She has developed immunologic assays to study transplacental transfer and decay kinetics of RSV antibody, and nosocomial and household transmission of respiratory viruses by genotypic analysis and molecular sequencing.

Recent Publications (PubMed)

Knowledge About Respiratory Syncytial Virus and Acceptance of Infant Monoclonal Antibody for RSV and RSV Vaccination During Pregnancy.
(2025 Feb 1)
Pediatr Infect Dis J 44(2S): S162-S166
Kuntz JL, Babu TM, Feldstein LR, Englund JA, Frivold CJ, Groom HC, Smith N, Varga AM, Cox SN, Fortmann SP, Mularski RA, Schmidt MA, Weil AA, Boisvert CL, Hollcroft M, Hatchie TL, Lo N, MacMillan MP, Reich S, Yetz N, Chu HY, Naleway AL
APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence.
(2025 Feb 6)
Nat Commun 16(1): 1402
Xie J, Chen DG, Chour W, Ng RH, Zhang R, Yuan D, Choi J, McKasson M, Troisch P, Smith B, Jones L, Webster A, Rasheed Y, Li S, Edmark R, Hong S, Murray KM, Logue JK, Franko NM, Lausted CG, Piening B, Algren H, Wallick J, Magis AT, Watanabe K, Mease P, Greenberg PD, Chu H, Goldman JD, Su Y, Heath JR
SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals.
(2025 Jan 20)
bioRxiv
Dadonaite B, Burrell AR, Logue J, Chu HY, Payne DC, Haslam DB, Staat MA, Bloom JD
APMAT analysis reveals the association between CD8 T cell receptors, cognate antigen, and T cell phenotype and persistence.
(2025 Jan 9)
bioRxiv
Xie J, Chen DG, Chour W, Ng RH, Zhang R, Yuan D, Choi J, McKasson M, Troisch P, Smith B, Jones L, Webster A, Rasheed Y, Li S, Edmark R, Hong S, Murray KM, Logue JK, Franko NM, Lausted CG, Piening B, Algren H, Wallick J, Magis AT, Watanabe K, Mease P, Greenberg PD, Chu H, Goldman JD, Su Y, Heath JR
Effectiveness of mRNA COVID-19 vaccines and hybrid immunity in preventing SARS-CoV-2 infection and symptomatic COVID-19 among adults in the United States.
(2025 Jan 8)
J Infect Dis
Feldstein LR, Ruffin J, Wiegand RE, Borkowf CB, James-Gist J, Babu TM, Briggs-Hagen M, Chappell J, Chu HY, Englund JA, Kuntz JL, Lauring AS, Lo N, Carone M, Lockwood C, Martin ET, Midgley CM, Monto AS, Naleway AL, Ogilvie T, Saydah S, Schmidt MA, Schmitz JE, Smith N, Sohn I, Starita L, Talbot HK, Weil AA, Grijalva CG
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