Education
MD Medicine, University of California (San Francisco), 1984
MPH Epidemiology, University of Washington, 1989
Contact
University of Washington
Seattle, WA
Box 359927
Allergy and Infectious Diseases
Seattle, WA 98195
Research Areas
Research Interests
Dr. Celum's research currently focuses on HIV prevention and vaccine trials with the objective to find effective strategies to reduce HIV acquisition and transmission. She utilizes epidemiologic data on behavioral and biologic risk factors for HIV acquisition and transmission to identify potential intervention strategies and then to conduct randomized clinical trials to determine safety and efficacy of these interventions with biologic outcome measurements. Her current effort is focused on sexually transmitted diseases (STDs), particularly genital herpes, as co-factors for HIV acquisition and transmission and clinical trials of candidate HIV vaccines. First, she is investigating HSV-2 as a co-factor for HIV acquisition and transmission, through a large randomized trial of daily antivirals for HSV-2 suppression to determine whether HIV acquisition can be reduced by 50% among HIV-negative, HSV-2 seropositive women in two African sites, and among MSM in Peru and two US sites. Second, to determine the effect of genital herpes on HIV infectiousness, she is conducting a large multi-center trial of HSV-2 suppression among HIV-discordant couples in Africa and India. Third, she is studying the effect of HSV-2 on mucosal HIV shedding with a double-blind cross-over study of valacyclovir among HIV/HSV-2 co-infected men and women in Peru. Fourth, she is studying the prevalence, incidence and risk factors for HSV-1 and HSV-2 acquisition among high-risk men who have sex with men in a multi-center trial of a behavioral intervention (Project Explore). Fifth, as part of her interest in the evaluation of HIV vaccine trials, she is developing approaches to assess the effect of partially-effective HIV vaccines on viral set-point and disease progression, including a standardized approach to provision of antiretroviral therapy for breakthrough infections in phase III trials.
Dr. Celum has developed research clinical units in Seattle and Lima, Peru, to conduct epidemiologic studies and clinical trials of HIV prevention interventions and vaccines. In addition, she serves as the PI on two multi-center international clinical trials of HSV-2 suppression and HIV transmission with sites in Africa, India, and Latin America, which provide opportunities for graduate students interested in studying the epidemiology of STD and HIV infection
HIV prevention; microbicide; vaccine trials with the objective to find effective strategies to reduce HIV acquisition and transmission.Recent Publications (PubMed)
(2023 Sep)
J Int AIDS Soc 26(9): e26156
Mujugira A, Nakyanzi A, Donnell D, Boyer J, Stein G, Bulterys M, Naddunga F, Kyomugisha J, Birungi JE, Ssendiwala P, Nsubuga R, Muwonge TR, Musinguzi J, Sharma M, Celum CL
(2023)
PLOS Glob Public Health 3(9): e0000610
Sahu M, Bayer CJ, Roberts DA, van Rooyen H, van Heerden A, Shahmanesh M, Asiimwe S, Sausi K, Sithole N, Ying R, Rao DW, Krows ML, Shapiro AE, Baeten JM, Celum C, Revill P, Barnabas RV
(2023 Aug)
J Int AIDS Soc 26(8): e26154
Celum C, Seidman D, Travill D, Dehlendorf C, Gumede S, Zewdie K, Wilson W, Morton JF, Baeten JM, Donnell D, Delany-Moretlwe S
(2023 Jul 20)
BMC Public Health 23(1): 1401
Klabbers RE, Muwonge TR, Ajidiru S, Borthakur S, Mujugira A, Sharma M, Vinck P, Pham P, Celum C, Parkes-Ratanshi R, O'Laughlin KN
(2023 Jul 20)
N Engl J Med 389(3): 286-287
Luetkemeyer AF, Cannon C, Celum C
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In the News
New York Post, 04/13/2023
The Seattle Times, 06/06/2022
SPH News, 10/23/2018
The Daily, 03/31/2016
Fox News/Reuters, 08/06/2015
KUOW, 07/18/2014
Seattle Weekly, 05/28/2013
SPH News, 07/10/2012