Faculty

Gerard Cangelosi

Adjunct Professor, Epidemiology
Professor, Env. and Occ. Health Sciences
Adjunct Professor, Global Health

206-534-2005
gcang@uw.edu

Education

PhD Microbiology, University of California (Davis), 1984

Contact

206-534-2005
gcang@uw.edu

Center for Infectious Disease Research
Office Suite 100
Box 354695
University of Washington
4225 Roosevelt Way NE
Seattle, WA 98195
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Research Interests

A cost-effective way to reduce global infectious diseases is to reduce transmission and infection of new hosts. We seek to accomplish this through 1) better case finding made possible by biomarker discovery and improved diagnostic tools; 2) improved detection of pathogens in water, food, and other environmental sources; and 3) better understanding of the epidemiology of infectious disease acquisition. Our translational research interests include:

  • Tuberculosis biomarkers and diagnosis. In collaboration with research and clinical partners in Washington, California, and South Africa, we are working to identify biomarkers of active TB and to develop improved point-of-care tools for detecting TB biomarkers in patient samples.
  • Molecular detection of pathogens in environmental and clinical samples. As a method for detecting microorganisms in samples, the polymerase chain reaction (PCR) is fast, sensitive, and specific. However, it is unable to distinguish viable pathogen cells from dead cells and free nucleic acid fragments. We have shown that PCR tests for ribosomal RNA precursors (pre-rRNA) can overcome this problem. In collaboration with a Seattle-based commercial licensee, AttoDx, Inc, we are developing pre-rRNA tests for pathogen detection in environmental as well as clinical samples.
  • Understanding human exposure to tuberculosis and related diseases. Transmission and exposure are among the most poorly understood aspects of bacterial disease. Mycobacterium tuberculosis, a globally important microbial pathogen, and related environmental mycobacteria are useful models for understanding how infectious diseases emerge and spread. Molecular and epidemiological methods are being used to characterize the host, pathogen, and environmental factors involved in the acquisition of mycobacterial infections.

Recent Publications (PubMed)

A Look Inside: Oral Sampling for Detection of Non-Oral Infectious Diseases.
(2021 Apr 22)
J Clin Microbiol
Valinetz ED, Cangelosi GA

Sample adequacy controls for infectious disease diagnosis by oral swabbing.
(2020)
PLoS One 15(10): e0241542
Deviaene M, Weigel KM, Wood RC, Luabeya AKK, Jones-Engel L, Hatherill M, Cangelosi GA

Integrated nucleic acid testing system to enable TB diagnosis in peripheral settings.
(2020 Oct 27)
Lab Chip 20(21): 4071-4081
Lu HW, Sakamuri R, Kumar P, Ferguson TM, Doebler RW, Herrington KD, Talbot RP, Weigel KM, Nguyen FK, Cangelosi GA, Narita M, Boyle DS, Niemz A

Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing.
(2020 Jul 30)
N Engl J Med 383(5): 494-496
Tu YP, Jennings R, Hart B, Cangelosi GA, Wood RC, Wehber K, Verma P, Vojta D, Berke EM

Association between Mycobacterium avium Complex Pulmonary Disease and Mycobacteria in Home Water and Soil.
(2020 Jan)
Ann Am Thorac Soc 17(1): 57-62
Tzou CL, Dirac MA, Becker AL, Beck NK, Weigel KM, Meschke JS, Cangelosi GA

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