Faculty

Gerard Cangelosi

Adjunct Professor, Epidemiology
Professor, Env. and Occ. Health Sciences
Adjunct Professor, Global Health
Associate Dean, School of Public Health

206-534-2005
gcang@uw.edu

Education

PhD Microbiology, University of California (Davis), 1984

Contact

206-534-2005
gcang@uw.edu

Center for Infectious Disease Research
Office Suite 100
Box 354695
University of Washington
4225 Roosevelt Way NE
Seattle, WA 98195
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Research Interests

A cost-effective way to reduce global infectious diseases is to reduce transmission and infection of new hosts. We seek to accomplish this through 1) better case finding made possible by biomarker discovery and improved diagnostic tools; 2) improved detection of pathogens in water, food, and other environmental sources; and 3) better understanding of the epidemiology of infectious disease acquisition. Our translational research interests include:

  • Tuberculosis biomarkers and diagnosis. In collaboration with research and clinical partners in Washington, California, and South Africa, we are working to identify biomarkers of active TB and to develop improved point-of-care tools for detecting TB biomarkers in patient samples.
  • Molecular detection of pathogens in environmental and clinical samples. As a method for detecting microorganisms in samples, the polymerase chain reaction (PCR) is fast, sensitive, and specific. However, it is unable to distinguish viable pathogen cells from dead cells and free nucleic acid fragments. We have shown that PCR tests for ribosomal RNA precursors (pre-rRNA) can overcome this problem. In collaboration with a Seattle-based commercial licensee, AttoDx, Inc, we are developing pre-rRNA tests for pathogen detection in environmental as well as clinical samples.
  • Understanding human exposure to tuberculosis and related diseases. Transmission and exposure are among the most poorly understood aspects of bacterial disease. Mycobacterium tuberculosis, a globally important microbial pathogen, and related environmental mycobacteria are useful models for understanding how infectious diseases emerge and spread. Molecular and epidemiological methods are being used to characterize the host, pathogen, and environmental factors involved in the acquisition of mycobacterial infections.

Recent Publications (PubMed)

Complementary Nonsputum Diagnostic Testing for Tuberculosis in People with HIV Using Oral Swab PCR and Urine Lipoarabinomannan Detection.
(2022 Aug 17)
J Clin Microbiol 60(8): e0043122
Shapiro AE, Olson AM, Kidoguchi L, Niu X, Ngcobo Z, Magcaba ZP, Ngwane MW, Whitman GR, Weigel KM, Wood RC, Wilson DPK, Drain PK, Cangelosi GA

Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV.
(2022 Aug 1)
AIDS 36(10): 1363-1371
Valinetz ED, Matemo D, Gersh JK, Joudeh LL, Mendelsohn SC, Scriba TJ, Hatherill M, Kinuthia J, Wald A, Cangelosi GA, Barnabas RV, Hawn TR, Horne DJ

Performance of anterior nares and tongue swabs for nucleic acid, Nucleocapsid, and Spike antigen testing for detecting SARS-CoV-2 against nasopharyngeal PCR and viral culture.
(2022 Apr)
Int J Infect Dis 117(): 287-294
MontaƱo MA, Bemer MJ, Heller KB, Meisner A, Marfatia Z, Rechkina EA, Padgett LR, Ahls CL, Rains D, Hao L, Hsiang TY, Cangelosi GA, Greninger AL, Cantera JL, Golden A, Peck RB, Boyle DS, Gale M Jr, Drain PK

Diagnostic performance of oral swabs for non-sputum based TB diagnosis in a TB/HIV endemic setting.
(2022)
PLoS One 17(1): e0262123
LaCourse SM, Seko E, Wood R, Bundi W, Ouma GS, Agaya J, Richardson BA, John-Stewart G, Wandiga S, Cangelosi GA

Pooling in a Pod: A Strategy for COVID-19 Testing to Facilitate a Safe Return to School.
(2021 Nov-Dec)
Public Health Rep 136(6): 663-670
Berke EM, Newman LM, Jemsby S, Hyde B, Bhalla N, Sheils NE, Oomman N, Reppas J, Verma P, Cangelosi GA

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