Ruanne Barnabas

Affiliate Professor, Epidemiology



DPhil Epidemiology, University of Oxford, 2005
MSc Epidemiology, University of Oxford, 2000
MBChB Medicine & Surgery, University of Cape Town (South Africa), 1997



55 Fruit St.
Boston, MA 02114
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Dr. Ruanne Barnabas is a South African physician-scientist and the Chief of the Division of Infectious Diseases at Massachusetts General Hospital (MGH).

Over the last 15 years, her research has focused on interventions for HIV and STD treatment and prevention and, more recently, on COVID-19 prevention. She is particularly interested in novel approaches that increase access to services. She has led clinical trials with companion health economic modeling to assess interventions' potential health and economic impact. For example, the Delivery Optimization for Antiretroviral therapy (DO ART) Study evaluated the efficacy and cost-effectiveness of decentralized, community-based ART initiation compared to standard clinic-based care. She also leads work assessing innovative strategies to increase access to care, including lottery incentives, home delivery, and ART monitoring. She is the Principal Investigator of the KEN SHE Study to assess the impact of single-dose human papillomavirus (HPV) vaccination in Kenya. Recently, her work has extended to COVID-19 prevention within households. Her work aims to identify effective and scalable HIV, HPV, and infectious disease treatment and prevention strategies to increase access across diverse communities and promote equity in health.

In addition to leading clinical trials and companion health economic modeling as an independently funded investigator, she also serves as an advisor to the World Health Organization and UNAIDS on cervical cancer elimination and treatment and prevention of HIV. She is on the planning committee for the AIDS 2022 conference. She was honored as a Fellow of the Infectious Diseases Society of America in 2020.

Dr. Barnabas graduated from the University of Cape Town, South Africa, where she received her medical degree. She received her research doctorate in medicine and clinical epidemiology from the University of Oxford, where she was a Rhodes Scholar. She completed her residency in South Africa and her fellowship in Infectious Diseases at the University of Washington, where she joined the faculty and was promoted to Professor of Global Health and Medicine before joining MGH in January 2022.  


Recent Publications (PubMed)

The impact of prevention-effective PrEP use on HIV incidence: a mathematical modelling study.
(2022 Nov)
J Int AIDS Soc 25(11): e26034
Roberts DA, Bridenbecker D, Haberer JE, Barnabas RV, Akullian A

Fee for home delivery and monitoring of antiretroviral therapy for HIV infection compared with standard clinic-based services in South Africa: a randomised controlled trial.
(2022 Nov 3)
Lancet HIV
Barnabas RV, Szpiro AA, Ntinga X, Mugambi ML, van Rooyen H, Bruce A, Joseph P, Ngubane T, Krows ML, Schaafsma TT, Zhao T, Tanser F, Baeten JM, Celum C, van Heerden A, Deliver Health Study Team

Modelling cervical cancer elimination using single-visit screening and treatment strategies in the context of high HIV prevalence: estimates for KwaZulu-Natal, South Africa.
(2022 Oct)
J Int AIDS Soc 25(10): e26021
Rao DW, Bayer CJ, Liu G, Chikandiwa A, Sharma M, Hathaway CL, Tan N, Mugo N, Barnabas RV

Assessing the sustainability of the Systems Analysis and Improvement Approach to increase HIV testing in family planning clinics in Mombasa, Kenya: results of a cluster randomized trial.
(2022 Oct 4)
Implement Sci 17(1): 70
Long JE, Eastment MC, Wanje G, Richardson BA, Mwaringa E, Mohamed MA, Sherr K, Barnabas RV, Mandaliya K, Jaoko W, McClelland RS

Dapivirine ring HIV-1 prevention effectiveness for women engaged in vaginal and anal intercourse: insights from mathematical modeling.
(2022 Oct 3)
J Acquir Immune Defic Syndr
Peebles K, Brown ER, Hendrix CW, Palanee-Phillips T, van der Straten A, Harkoo I, Reddy K, Mirembe BG, Jeenarain N, Hillier SL, Baeten JM, Barnabas RV, MTN-020/ASPIRE study team

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