MS
October 1, 2024
Inequities in access to mental health care at intersections of race/ethnicity, gender identity, and gender modality: An application of Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA)
Transgender populations, and particularly transgender women of color, are burdened by high rates of both mental illness and healthcare avoidance. Despite this, research examining the patterns of non-use of mental healthcare within this community is lacking, and has further suffered due to the difficulty of collecting large, population-based samples of transgender adults in general, and…
Relationship Dynamics and Experiences of Expedited Partner Therapy Among Adolescent Girls and Young Women in Johannesburg, South Africa
Background: Adolescent girls and young women (AGYW) are disproportionately impacted by sexually transmitted infections (STIs). We evaluated associations between relationship dynamics and expedited partner therapy (EPT) acceptance and delivery, and delivery experiences, among AGYW diagnosed with an STI and participating in a prospective cohort study (ARISE). Setting: Participants attending a research clinic in Johannesburg, South…
Stroke risk associated with atrial fibrillation: a Burden of Proof study.
Atrial fibrillation (AF) is increasingly recognized as a significant predictor for stroke, carrying profound implications for morbidity and mortality globally. This study aims to explore the relationship between AF and stroke incidence and/or stroke mortality (in 30 days) by employing the Burden of Proof methodology. Utilizing a systematic review and meta-analysis of published observational studies…
Evaluation of interfacility transfer patterns among emergency general surgery patients.
Background: Interfacility transfer for emergency general surgery (EGS) is a key strategy for improving access to care. However, low-intensity transfers with short stays and without procedural intervention are linked to increased costs, poor patient and family experience, and poor resource allocation. Clinical and health system characteristics associated with low-intensity transfers among patients with EGS conditions…
The Epidemiology and Causes of Global and Regional Sepsis Mortality in Children Under Five, 1990-2021: A Systematic Analysis
University of Washington Abstract The Epidemiology and Causes of Global and Regional Sepsis Mortality in Children Under Five, 1990–2021: A Systematic Analysis Erin Chung Chair of the Supervisory Committee:Jeffrey Stanaway Health Metrics Sciences Introduction: Despite the significant burden of sepsis in children under five years of age, estimating the global burden of sepsis in this…
Association between 4CMenB vaccination and gonorrhea rates in Washington state by anatomic infection site
Background: N. gonorrhoeae control and prevention is an urgent public health concern. Previous studies have observed that 4CMenB is associated with a decrease in gonorrhea infections, but there have been no observational studies that evaluated whether this association differs by anatomic infection site. Methods: We conducted an observational study in Washington state among all people…
March 13, 2024
Emergency Department Utilization and Unplanned Hospitalizations Associated with Floods in the US from 2008-2017: An Interrupted Time Series and Cohort Analysis
Flooding is a major environmental hazard, with events increasing in intensity and frequency in the context of anthropogenic climate change. Significant health and economic impacts result from floods, particularly among vulnerable populations. However, comprehensive analyses of the health consequences of flooding, especially in terms of healthcare utilization and associated costs in the United States, remain…
Phase 2 randomized open label adaptive platform clinical trial of the clinical and biological effects of IC14 treatment in patients with severe COVID-19
In I-SPY COVID, a Phase 2 randomized open label adaptive platform clinical trial, we examined the clinical efficacy of the anti-CD14 monoclonal antibody IC14 for patients with severe COVID-19 requiring high-level respiratory support. As detailed in the initial report of the first seven investigational agents, IC14 treatment did not satisfy the Bayesian criteria for a…
Incidence and Outcomes of Late-Onset Right Ventricular Failure in Patients with Left Ventricular Assist Device
Right Ventricular Failure (RVF) is an incompletely understood complication observed in patients undergoing durable left ventricular assist device (LVAD) implantation. Prior research has primarily concentrated on early post-implantation RVF. This study seeks to characterize the incidence and clinical features associated with late-onset RVF in LVAD patients. Methods: This retrospective cohort study included individuals undergoing LVAD…
December 26, 2023
Changes in vaginal bacteria and inflammatory mediators from periconception through early-postpartum in a cohort of HIV-negative Kenyan women
Women’s increased risk of HIV acquisition during pregnancy and the postpartum period maybe mediated by changes in vaginal microbiota and/or cytokines. Methods: A cohort of HIV-1-seronegative Kenyan women contributed vaginal fluid samples at six pregnancy time points: periconception, positive pregnancy test, first trimester, second trimester, third trimester and postpartum. Concentrations of vaginal bacteria previously associated…
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