MS
November 18, 2020
Genetic variation in telomere maintenance genes and survival after colorectal cancer diagnosis
INTRODUCTION Telomeres are the repetitive nucleotide sequences capping the end of chromosomes and are regulated by telomerase. Both telomere length and telomerase initiate carcinogenesis and prognosis in patients diagnosed with cancer, including colorectal cancer (CRC). Genome-wide association studies (GWAS) have identified several loci related to telomere length or telomerase activity, but the association between those…
Hospital Resource Utilization and Presence of Advance Directives at the End of Life for Adults with Congenital Heart Disease
OBJECTIVE Overall healthcare resource utilization by adults with congenital heart disease has increased dramatically in the last two decades. No prior studies have examined utilization at the end of life. The objective of this study is to better understand the patterns and influences on the intensity of care at the end of life for adults…
Transplant-Associated Thrombotic Microangiopathy (TA-TMA) is a Multifactorial Disease Unresponsive to Immunosuppressant Withdrawal
Background: Transplant-associated thrombotic microangiopathy (TA-TMA) after allogeneic hematopoietic cell transplantation (HCT) has not been well-characterized in large population studies with clinically adjudicated cases. Methods: We performed a retrospective cohort study of adults who underwent allogeneic HCT between 2006 and 2015 to determine the incidence of and risk factors for TA-TMA, and to describe its natural…
POLST-Discordant Intensive Care Near the End of Life: A Retrospective Cohort Study
Importance: Patients with chronic life-limiting illness frequently use the Physician Orders for Life Sustaining Treatment (POLST) to document preferences for limiting intensive care. However, the incidence and predictors of POLST-discordant care near the end of life are not known. Objective: To describe the incidence, predictors, and intensity of POLST-discordant intensive care among patients hospitalized near…
Health care service utilization of individuals in permanent supportive housing in Seattle, WA accessing care through Public Health – Seattle and King County’s Health Care for the Homeless Network
Introduction: Permanent supportive housing (PSH) programs combine non-time limited housing with optional supportive services, including case management and health care, and are designed for those facing barriers to housing stability. Prior studies suggest that PSH can reduce emergency room visits and health care expenditures for an individual while improving their housing stability and well-being. However,…
Racial/Ethnic Disparities in Risk of Breast Cancer Mortality by Molecular Subtype and Stage at Diagnosis
Previous research has found significant survival disparities between African-American and white women among select stages and subtypes of breast cancer, however other racial/ethnic groups have been less well-studied. This study expands on previous research, examining differences in breast cancer-specific mortality across multiple racial and ethnic groups. Women diagnosed with a first primary invasive breast cancer…
Hepatocellular carcinoma screening reduces cancer-related mortality in patients with chronic hepatitis B infection: a case-control study
Background: Patients with chronic hepatitis B (CHB) infection often undergo screening for hepatocellular carcinoma (HCC), but the efficacy of such screening remains unclear. We aimed to evaluate the impact of screening with ultrasound (USS) and/or serum alpha-fetoprotein (AFP) on HCC-related mortality in Veterans Affairs (VA) patients with CHB. Methods: We performed a matched case-control study….
November 17, 2020
Association of Guideline-recommended COPD Inhaler Regimens with Respiratory Exacerbations, Exercise Performance, and Quality of Life
Background: Although inhaled therapy reduces exacerbations among patients with COPD, the effectiveness of providing inhaled treatment according to recent risk-stratification models remains unclear. Research Question: Are inhaled regimens that align with the 2017 Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy associated with clinically important outcomes? Study Design and Methods: We conducted secondary analyses…
Genetic variation and natural anticoagulants
Protein C (PC), protein S (PS) and antithrombin (AT) belong to the main anticoagulant pathways that regulate hemostasis and further affect the risk of thrombotic events. Previous epidemiological studies of circulating levels of PC, PS and AT, genetic variation, and risk of venous thromboembolism (VTE) have been limited by small sample sizes and restriction to…
Effects of Washington’s Opioid Prescribing Rules for Chronic, Non-Cancer Pain Management on Opioid Overdose Mortality and Pharmaceutical Opioid Distribution: 1999-2017
Background Since the 1990s, the opioid crisis has affected individuals and communities across the United States. National and statewide comprehensive efforts to address the problem include policies to prevent opioid addiction, identify opioid-addicted individuals, and provide effective treatment. In Washington state, in response to rising prescription opioid-related overdose deaths, the legislature passed the Engrossed Substitute…
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