MS
May 12, 2022
Association of CPS Post-Response Daycare Services with Child Physical Abuse Recidivism
Introduction: Provision of services to families is a tool used by child welfare agencies after child maltreatment is reported, with an intention of preventing future child maltreatment reports. Little is known about the effectiveness of individual services in preventing child physical abuse recidivism.Methods: A retrospective cohort study was performed of data from 23 states contributing…
May 10, 2022
Hyperoxia After Pediatric Cardiac Arrest: Association with Survival and Neurological Outcomes
Objective: To evaluate the association between hyperoxia in the first 24 hours after in-hospital pediatriccardiac arrest and mortality and poor neurological outcome. Design: Retrospective cohort study. Setting: Tertiary care freestanding children’s hospital. Patients: Patients younger than 18 years of age with in-hospital cardiac arrest between December 2012 and December 2019, who achieved return of circulation…
August 5, 2021
Investigating Health Inequality in Primary Care Spatial Accessibility Among Races and Ethnicities in King County Using a Geospatial Approach
Distance to healthcare providers is a significant barrier to health care access in the U.S. Healthcare utilization and disease burden have been found to increase as the distance between patients and primary care physicians increase. Although spatial accessibility to primary care resources has been studied using different methods in recent decades, few studies have addressed…
An investigation of expression quantitative trait loci in interferon genes in childhood asthma using RNA-sequencing data
Background: Asthma is the most common chronic disease among children and yet, many of the underlying mechanisms of severe disease remain poorly understood. Expression quantitative trait loci (eQTL) can provide mechanistic insight into the consequences of asthma risk variants and help explain variation in asthma severity. We identified and evaluated eQTLs in interferon molecular networks…
January 14, 2021
Outcomes of Beta-Hemolytic Streptococcal Necrotizing Skin and Soft Tissue Infections and the Impact of Clindamycin Resistance
Background: Beta-hemolytic streptococci are frequently implicated in necrotizing soft tissue infections (NSTI). Clindamycin administration may improve outcomes in patients with serious streptococcal infections. However, clindamycin resistance is growing worldwide, and resistance patterns in NSTI and their impact on outcomes are unknown. Methods: Between 2015 and 2018, NSTI patients at a quaternary referral center were followed…
Identifying patient level factors of prone positioning therapy
BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) is an important cause of respiratory failure associated with high mortality and morbidity. Prone positioning (proning) is a proven therapy for ARDS and is strongly recommended by the American Thoracic Society guidelines. Despite this, it is vastly underutilized in eligible patients. We sought to determine the patient-level factors associated…
Patient-reported receipt of goal-concordant care among seriously ill outpatients – prevalence and associated factors
Goal-concordant care is an important indicator of high-quality care in serious illness. We sought to estimate the prevalence of patient-reported receipt of goal-concordant care among seriously ill outpatients and identify factors associated with absence of patient-reported goal-concordance. We analyzed enrollment surveys from a multi-center cluster-randomized trial of outpatients with serious illness. Patients reported their prioritized…
Validity of Identification Methods of Lower Extremity Amputation in the Veterans Health Administration Electronic Medical Records
It is not currently known what the best method to identify individuals with lower extremity amputation (LEA) is. The purpose of this study is to determine the positive predictive value (PPV) of algorithms used to identify patients with LEA using Veterans Health Administration (VHA) electronic medical records (EMR) and to determine if PPV varies by…
Exercise Partially Explains the Impact of Body Mass Index on Disease Activity in Ankylosing Spondylitis
Background. Ankylosing spondylitis (AS) patients have elevated cardiovascular (CV) morbidity and mortality compared to general population comparators of the same age and sex. Although obesity is an important and modifiable CV risk factor, there are few prospective studies addressing the impact of higher body mass index (BMI) on clinical outcomes in AS. The aim of…
Factors associated with reduced lung function in adolescents living with HIV in Nairobi, Kenya
Background: Over 5 million children and adolescents are living with HIV (ALWH) worldwide as a result of perinatally-acquired disease. Recent data support high prevalence of chronic respiratory symptoms in this population and a predominant phenotype of irreversible airflow obstruction. The objective of this study was to better understand factors associated with chronic lung disease in…
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