MS
November 24, 2020
Defining Optimal T-Cell Characteristics for Pediatric Chimeric Antigen Receptor (CAR) T-cell Trials
BACKGROUND Engineered chimeric antigen receptor (CAR) T cells have emerged as a powerful, highly personalized immunotherapy in pediatric cancer. Early phase clinical trials using CAR T cells targeting CD19 have resulted in complete response (CR) rates as high as 93% in children with relapsed and refractory acute lymphoblastic leukemia (ALL). Despite this success, there are…
November 23, 2020
Impact of Cancer, Cancer Directed Therapy and Its Lasting Effects on Employment and Finances in Young Adult Cancer Survivors
BACKGROUND Young adult (YA) cancer survivors face challenges unique from survivors of childhood cancer or older adults. The potential impact of cancer or its treatment upon employment and financial burden in YAs are not fully known. METHODS We conducted a multi-center, cross-sectional study of YA cancer survivors. Eligibility included diagnosis of malignancy between ages 18-39,…
November 19, 2020
The impact of chronic kidney disease on chronic school absenteeism
Background: School absenteeism is an important predictor of low academic success. Children with chronic illness are at increased risk of school absenteeism due to disease-specific and psychosocial factors. The prevalence of chronic school absenteeism is not well described in the chronic kidney disease (CKD) population. Objective: The purpose of this study was to document the…
Demographic Characteristics and Diagnostic Performance of Pathologists who Enjoy Interpreting Melanocytic Skin Lesions
Background: Diagnostic errors among pathologists when interpreting melanocytic skin lesions (MSL) is an ongoing concern for patient safety and quality of care. The number of skin biopsies has increased annually over the past decade, subsequently applying a higher demand on pathologists’ work performance. Given that physician job satisfaction can plausibly impact upon patient care, we…
Resolution of Sepsis-Associated Acute Kidney Injury: Association with Emergency Department Fluid Management Patterns
Background: Sepsis is the most common cause of acute kidney injury (AKI). AKI is associated with poor outcomes including progression to chronic kidney disease, increased intensive care unit and hospital length of stay, and mortality. Recent evidence suggests that trajectory of AKI (duration and resolution/persistence), rather than KDIGO stage, is associated with these poor outcomes….
November 18, 2020
Beta Lactam and Other Antibiotic Allergies in Solid Organ and Hematopoietic Cell Transplant Recipients
Background Patients with reported beta lactam antibiotic allergies (BLA) are more likely to receive broad-spectrum antibiotics and experience adverse outcomes. Data on the burden of beta lactam and other antibiotic allergies among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients are limited. Methods We reviewed records of first-time adult SOT or allogeneic HCT…
Outcomes of Wraparound Care Coordination for Youth with Complex Behavioral Health Needs
Background. Approximately 10% of youth in the US are estimated to experience “serious emotional disorder,” or SED. Wraparound is a commonly implemented care coordination process for youth with SED and complex needs, but effectiveness research is sparse, and results have been mixed. RCTs have found favorable effects of Wraparound on child welfare placements and service…
Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
In vitro testing of cholinesterase inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting pathologies associated with Alzheimer’s Disease. Imaging studies had inconsistent results. Our objective was to assess the impact…
Social Determinants of Asthma in American Indian Children
BACKGROUND American Indian (AI) / Alaska Native (AN) children have a higher asthma prevalence than white children in the U.S. (9.4% versus 7.7%, respectively). The AI/AN population is extremely diverse; demographic, lifestyle, genetic, and environmental factors influence asthma prevalence and severity in these communities. Our study sought to examine risk factors associated with asthma among…
Detection of protein targets associated with survival in malignant pediatric brain tumors
BACKGROUND Brain tumors are the leading cause of pediatric cancer death. Specific protein detection by immunohistochemistry may predict patient survival and identify opportunities for targeted therapy. The purpose of this study was to evaluate the prevalence of selected protein markers to prioritize targets for further therapeutic study. PROCEDURE We studied a single institution cohort of…
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