Graduate
November 18, 2020
Integrating data systems to improve HIV care engagement in King County, WA
Continuous engagement in HIV care and treatment is crucial for the health of persons living with HIV (PLWH) and for preventing HIV transmission to others. However, in the United States (US), care engagement, or retention in care, represents the biggest drop off in the HIV care continuum, which maps out the care process from HIV…
POLST-Discordant Intensive Care Near the End of Life: A Retrospective Cohort Study
Importance: Patients with chronic life-limiting illness frequently use the Physician Orders for Life Sustaining Treatment (POLST) to document preferences for limiting intensive care. However, the incidence and predictors of POLST-discordant care near the end of life are not known. Objective: To describe the incidence, predictors, and intensity of POLST-discordant intensive care among patients hospitalized near…
The Vaginal Microbiome: The Influence of Intramuscular Depot-medroxyprogesterone Acetate Initiation on Vaginal Microbiota and A Comparison of PCR Approaches for Use in Predicting HIV Acquisition
The vaginal microbiome is a key factor in women’s reproductive health and hormones may play an important role in the composition of vaginal bacterial communities. The vaginal microbiome is commonly evaluated using broad-range polymerase chain reaction (PCR) with next generation sequencing (NGS) or taxon-specific quantitative PCR (qPCR); both approaches have advantages and disadvantages. We sought…
Health care service utilization of individuals in permanent supportive housing in Seattle, WA accessing care through Public Health – Seattle and King County’s Health Care for the Homeless Network
Introduction: Permanent supportive housing (PSH) programs combine non-time limited housing with optional supportive services, including case management and health care, and are designed for those facing barriers to housing stability. Prior studies suggest that PSH can reduce emergency room visits and health care expenditures for an individual while improving their housing stability and well-being. However,…
Engaging Male Partners in Home-based Couple Education and Testing for Syphilis and HIV
For HIV and other sexually transmitted infections (STIs), men seek care at more advanced stages of disease and are less likely to initiate treatment.1-4 Male partner participation in antenatal care (ANC) has been shown to increase male and female HIV testing,5,6 identification of HIV-discordant couples,7,8 female participation in ANC and uptake of PMTCT services1,9 as…
Receptiveness and Responsiveness of Using Social Media for Safe Firearm Storage Outreach in Washington State: A Mixed-Methods Study
Background: Childhood and adolescent firearm injury and death have increased over the past decade and become a major public health concern in the United States. There is a growing disparity in the incidence of these events occurring in rural compared to urban areas. Safe firearm storage have shown to be an effective measure to prevent…
Investigation of Pertussis Resurgence in King County, Washington
Introduction: Pertussis or “whooping cough” is an infectious disease caused by bacterium Bordetella pertussis. Despite widespread vaccination since the 1950s, it continues to cause epidemics in several countries. In fact, in the last three decades, many countries with high vaccination coverage have reported a resurgence in pertussis activity. Understanding the factors that led to pertussis…
Diet, inflammation, and genetic predictors of tissue-specific gene expression: A functionally-informed gene-environment interaction analysis for risk of colorectal cancer.
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in both sexes combined worldwide, as well as the second leading cause of cancer deaths. Pathogenesis of CRC can be attributed to both genetic (G) and environmental (E) factors. Among environmental risk factors, dietary factors contribute significantly to the etiology of CRC. Extensive research has…
Serum Concentrations of Novel Vitamin D Biomarkers and Detection of Prevalent High-Risk HPV Infection
Introduction: Vitamin D has potential immunomodulating benefits in infection. While one prior population-based cross-sectional study showed a protective association between serum concentrations of 25(OH)D and high-risk HPV (hrHPV) infection, additional biomarkers present at different stages along the vitamin D metabolic pathway may more completely characterize vitamin D status than 25(OH)D alone. We evaluated cross-sectional associations…
Racial/Ethnic Disparities in Risk of Breast Cancer Mortality by Molecular Subtype and Stage at Diagnosis
Previous research has found significant survival disparities between African-American and white women among select stages and subtypes of breast cancer, however other racial/ethnic groups have been less well-studied. This study expands on previous research, examining differences in breast cancer-specific mortality across multiple racial and ethnic groups. Women diagnosed with a first primary invasive breast cancer…
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