Graduate
May 10, 2022
Hepatitis C Prevalence, Correlates, and Social Networks among Cisgender Women who Participate in Sex Work in Seattle, WA
Background: Globally, injection drug use (IDU) is common among cisgender women who participate in sex work (CWSW), placing them at heightened risk of HCV acquisition and transmission. However, the epidemiology of HCV among CWSW in the United States is not well understood. In this study among CWSW in Seattle, we sought to estimate HCV prevalence,…
Hyperoxia After Pediatric Cardiac Arrest: Association with Survival and Neurological Outcomes
Objective: To evaluate the association between hyperoxia in the first 24 hours after in-hospital pediatriccardiac arrest and mortality and poor neurological outcome. Design: Retrospective cohort study. Setting: Tertiary care freestanding children’s hospital. Patients: Patients younger than 18 years of age with in-hospital cardiac arrest between December 2012 and December 2019, who achieved return of circulation…
A prospective study of the association between living with an adult who misuses alcohol during childhood and major depressive disorder in adulthood: Evaluating the role of child maltreatment, sex, school bonding, and neighborhood bonding
Purpose: This prospective cohort study evaluated (1) the association between living with adult alcohol misuse during childhood and chronicity of major depressive disorder (MDD) during one’s thirties, (2) whether the association is explained by child maltreatment, and (3) whether the association is moderated by sex, school bonding, and neighborhood bonding during childhood. Methods: Longitudinal data…
August 6, 2021
Cancer incidence, mortality, and immunotherapy outcomes in relation to sleep problems: Results from Cardiovascular Health Study and a cancer immunotherapy cohort
Background: Sleep problems (SP) affect a large proportion of adults: an estimated 50-70 million U.S. adults suffer from sleep problems. Among numerous potential health consequences, sleep problems may be adversely associated with cancer risk and cancer mortality. There has been evidence from human studies and numerous animal studies linking sleep problems to cancer development and…
Diabetes Mellitus as a Risk Factor for Tuberculosis in HIV-Infected and Uninfected Populations
Tuberculosis (TB) is one of the leading infectious causes of morbidity and mortality worldwide. Diabetes and HIV are important risk factors that contribute to the persistently high TB incidence globally. However, the importance of diabetes on TB risk in key sub-populations is not well-established. Additionally, body mass index (BMI) affects both TB and diabetes risk,…
August 5, 2021
Investigating Health Inequality in Primary Care Spatial Accessibility Among Races and Ethnicities in King County Using a Geospatial Approach
Distance to healthcare providers is a significant barrier to health care access in the U.S. Healthcare utilization and disease burden have been found to increase as the distance between patients and primary care physicians increase. Although spatial accessibility to primary care resources has been studied using different methods in recent decades, few studies have addressed…
An investigation of expression quantitative trait loci in interferon genes in childhood asthma using RNA-sequencing data
Background: Asthma is the most common chronic disease among children and yet, many of the underlying mechanisms of severe disease remain poorly understood. Expression quantitative trait loci (eQTL) can provide mechanistic insight into the consequences of asthma risk variants and help explain variation in asthma severity. We identified and evaluated eQTLs in interferon molecular networks…
January 14, 2021
Outcomes of Beta-Hemolytic Streptococcal Necrotizing Skin and Soft Tissue Infections and the Impact of Clindamycin Resistance
Background: Beta-hemolytic streptococci are frequently implicated in necrotizing soft tissue infections (NSTI). Clindamycin administration may improve outcomes in patients with serious streptococcal infections. However, clindamycin resistance is growing worldwide, and resistance patterns in NSTI and their impact on outcomes are unknown. Methods: Between 2015 and 2018, NSTI patients at a quaternary referral center were followed…
Identifying patient level factors of prone positioning therapy
BACKGROUND: Acute Respiratory Distress Syndrome (ARDS) is an important cause of respiratory failure associated with high mortality and morbidity. Prone positioning (proning) is a proven therapy for ARDS and is strongly recommended by the American Thoracic Society guidelines. Despite this, it is vastly underutilized in eligible patients. We sought to determine the patient-level factors associated…
Patient-reported receipt of goal-concordant care among seriously ill outpatients – prevalence and associated factors
Goal-concordant care is an important indicator of high-quality care in serious illness. We sought to estimate the prevalence of patient-reported receipt of goal-concordant care among seriously ill outpatients and identify factors associated with absence of patient-reported goal-concordance. We analyzed enrollment surveys from a multi-center cluster-randomized trial of outpatients with serious illness. Patients reported their prioritized…
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