Graduate
August 26, 2025
Tumor Microbial Biodiversity and Microsatellite Instability in Colorectal Cancer
Background: There is growing interest in characterizing how the gut microbiome is related to colorectal cancer (CRC) progression and etiology after several species have been found to be strongly enriched in certain molecular subtypes of CRC tumors. DNA mismatch repair deficiency in CRC is associated with a favorable prognosis and positive response to immunotherapy, and…
Establishing Age-Specific Normative Data for the NIH Toolbox among Urban-Dwelling American Indian and Alaska Native Elders in the URBANE Study
This study presents group norms for fluid, crystallized, and total cognition scores on the NIH Toolbox among urban-dwelling American Indian and Alaska Native (AI/AN) Elders. From 2021 to 2024, the URBan Native Elders study recruited 1007 (n = 994) Elders to elucidate risk and protective factors for Alzheimer’s Disease and related dementias (ADRD). Volunteers self-identified…
Users of a Container-Based Sanitation Service Experience High Sanitation-Related Quality of Life: A Prospective Cohort Study in Cap Haitien, Haiti
Sanitation users often value improved sanitation interventions for social benefits, such as improved safety and dignity. Some sanitation providers have started using well-being measurements to evaluate service impacts beyond infectious disease outcomes. In particular, the Sanitation Quality of Life (SanQoL) Index explores five attributes associated with sanitation wellbeing: health, disgust, shame, safety, and privacy. In…
Clinical Sub-Phenotypes of Acute Lung Allograft Dysfunction Associated with Chronic Lung Allograft Dysfunction
Background:Chronic lung allograft dysfunction (CLAD) is the leading cause of mortality after the first year following lung transplantation (LTx). Acute lung allograft dysfunction (ALAD), defined by a ≥10% decline in FEV₁ from baseline best for at least 3 weeks, is a precursor to CLAD. However, only 40% of LTx recipients with ALAD progress to CLAD…
August 12, 2025
Comparison of Three Treatment Regimens for Latent Syphilis of Late or Unknown Duration Using Public Health Surveillance Data
Background: The CDC recommends treating latent syphilis of late/unknown duration (LSUD) with three doses of intramuscular benzathine penicillin G (BPG) or twenty-eight days of oral doxycycline. This recommendation lacks high-quality evidence. Methods: Using public health surveillance data from King County, Washington, we conducted a retrospective cohort study comparing rates of serological cure (>=2-titer RPR decline)…
A study on the association between educational attainment and substance use disorder from ages 33 to 47, and the moderating role of perceived neighborhood social cohesion
A study on the association between educational attainment and substance use disorder from ages 33 to 47, and the moderating role of perceived neighborhood social cohesion. Shawna Hui Chair of the Supervisory Committee:Isaac Rhew Department of Epidemiology & Department of Psychiatry and Behavioral Sciences Purpose: Examine the association between educational attainment at age 27 and…
A Nationwide Analysis of Financial Hardship After Surgery
Background and Objectives: Affordable access to surgical remains elusive for many in the US. However, the financial hardship attributable to surgery is not well understood at the national level. Our objectives were to (1) evaluate the association between surgery and financial hardship among working age adults in the US, (2) compare changes in financial hardship…
Ultra-processed foods, plant and animal source, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study
Background: Ultra processed food (UPF) consumption is associated with adverse health outcomes. Plant- and animal-sourced UPF have a unique nutritional composition to improve palatability which may impact health, but evidence is limited. The objective of this study aimed to investigate the association between UPF intake, plant-, and animal-sourced UPF, and mortality outcomes in older adults….
Elexacaftor/Tezacaftor/Ivacaftor Prescription in Lung Transplant Recipients with Cystic Fibrosis in the US
Elexacaftor/tezacaftor/ivacaftor (ETI) has dramatically improved pulmonary and extrapulmonary manifestations of cystic fibrosis (CF). ETI clinical trials excluded lung transplant (LTx) recipients, and current post-transplant prescribing practices are not evidence-based. We sought to identify the prevalence of new ETI prescriptions among CF LTx recipients in the United States (U.S.) and factors associated with ETI prescription after…
Factors associated with mortality and the need for re-intervention after stage 1 palliation for single ventricle heart disease
Background: Single ventricle management comprises a series of complex surgical procedures that are initiated during the newborn period. Despite advancements in surgical techniques, infants with a single ventricle face high mortality and the likelihood of unplanned reinterventions. Understanding the factors contributing to these reinterventions potentially could enhance patient outcomes, improve preoperative risk counseling to the…
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