Graduate
December 21, 2022
Associations of Fatty Liver Disease with Recovery After Traumatic Injury
Fatty liver disease (FLD) is prevalent among US adults (20-30%) and associated with chronic systemic inflammation, extra-hepatic comorbidities, and socioeconomic risk factors for poor health outcomes. These factors may directly and indirectly contribute to an individual’s recovery from traumatic injury. However, FLD has not been studied as a risk factor for poor outcomes in the…
COVID-19 Vaccination Among Hospitalized Patients at Seattle Children’s Hospital
COVID-19 vaccines are recommended for children and adolescents 5-17 years old; however, little available data have described children and adolescents who have been vaccinated against COVID-19, particularly those who are at the highest risk of complications. This study aimed to characterize hospitalized patients 5-17 years old who received a COVID-19 vaccine before hospital admission and…
Mycobacterium tuberculosis DNA detection on tongue swabs: Effect of anti-tuberculosis drug treatment
Oral swab analysis (OSA) can be used to detect Mycobacterium tuberculosis (MTB) DNA in patients with pulmonary tuberculosis (TB). No previous analyses have investigated the effect of anti-tuberculosis drug treatment on MTB detection via oral swabs. This study, using a cross-sectional design, evaluated the sensitivity and specificity of OSA post-treatment initiation relative to sputum culture….
Assessing Relationships Between Adverse Childhood Experiences and Viral Suppression Among Persons Living with HIV in Washington State
Background: Adverse childhood experiences (ACEs) have been linked to a variety of negative health outcomes in adulthood and have been recognized as a hurdle to participating in HIV care. However, few studies have examined the cumulative impact that different types of childhood trauma have on HIV care engagement and HIV outcomes. To address this gap,…
Firearm Suicide and Perceived Physical Health Challenges: A Case-Control Study
Firearm suicide is a critical public health issue in the United States as firearms are the mechanism for the majority of all suicides and suicides account for more than half of all firearm-related deaths. Prior research has identified certain physical health diagnoses as well as functional disability as risk factors for suicide particularly among individuals…
Diet Quality and Kidney Outcomes in Adolescent and Adult American Indians: The Strong Heart Family Study
Background: The burden of chronic and end stage kidney disease (CKD and ESKD) is exceedingly high amongst American Indians (AI). We sought to examine the relationship of diet quality, a modifiable risk factor, and kidney outcomes in AI adolescents and young adults, hypothesizing that healthier diets are associated with lower odds of incident albuminuria and…
Factors associated with facilitators and barriers to gender-affirming care among transgender and nonbinary youth and young adults in Washington: A mixed-methods approach
Background: Access to gender-affirming care is associated with improved mental health among transgender and nonbinary (TNB) individuals, particularly among TNB youth. We conducted a mixed-methods study to examine the association of age with prevalence of facilitators and barriers to gender-affirming care among youth and adults who identify as TNB residing in Washington. In addition, we…
Cancer survival prediction of six cancer types with germline whole-exome sequencing data from the UK Biobank
Background: One of the most important tasks in cancer genomics is to predict cancer prognosis based on genetic signatures. We aim to apply machine learning approaches to germline whole-exome sequencing (WES) data to predict survival for breast cancer, colorectal cancer, kidney cancer, lung cancer, lymphoma, and prostate cancer. Methods: We analyzed the UK Biobank exome…
Development of CPAP Dose Response for Patients with Obstructive Sleep Apnea: Secondary Analysis
Background: First-line treatment for obstructive sleep apnea (OSA) is continuous positive airway pressure therapy (CPAP). Although CPAP is efficacious, the definition of adequate use (effectiveness) is known to be arbitrary. We aimed to characterize a CPAP dose response for short term outcomes, including sleepiness severity and quality of life. Methods We performed secondary analysis on…
Left atrial strain and the risk of arrhythmias on extended ambulatory cardiac monitoring: the Multi-Ethnic Study of Atherosclerosis
Background: Abnormalities in left atrial (LA) function can be identified before the development of overt LA structural changes. Little is known about the relationship between LA function and the risk of subclinical atrial and ventricular arrhythmias.Methods: 1,441 participants of the Multi-Ethnic Study of Atherosclerosis completed speckle-tracking echocardiography and cardiac monitoring during 2016-2018 (mean age 73…
Previous page Next page