Graduate
December 21, 2022
Correlates of infectious complications of injection drug use among individuals who use drugs in Washington State: An analysis of the 2021 Washington State Syringe Exchange Health Survey
Objectives: Increased use of injection drugs across the United States has likely increased the burden of complications from abscess or skin infections, blood clots or blood infections, and infectious endocarditis (IE) among people who inject drugs (PWID). Among PWID who attended syringe services programs (SSPs) in Washington State, we assessed the prevalence of complications from…
Associations between green space and depressive symptoms in young adults: a longitudinal study
As the number of people living in urban areas rises, it is becoming increasingly important to quantify the relationship between exposure to green space and physical and mental health. Young adulthood in particular is a critical period with profound impacts on health, and often has implications for health outcomes later in life. Our study population…
The association between Adverse Childhood Experiences and HPV vaccination coverage in US young adults: a cross-sectional study
Introduction: Adverse childhood experiences (ACEs) affect more than half of all children in the United States, and people with ACEs are more prone to various unhealthy situations in adulthood. Access to preventive healthcare services, including HPV vaccinations, may help reduce the impact of ACEs on adverse health outcomes. Our objective was to assess the prevalence…
Association Between Sleep Duration and Fruit and Vegetable Consumption in United States Adults and Veterans
INTRODUCTION: Adequate sleep and a diet rich in fruits and vegetables are essential components of a healthy lifestyle. A growing body of evidence suggests an association between sleep duration and fruit and vegetable (FV) consumption, but it has not been well established in U.S. adults. It’s unclear if this association differs for groups at higher…
Novel Estimation of Genetic Relationship Matrix (GRM) and Comparisons of Different GRMs in Mega- and Meta- GWAS, in the NHLBI TOPMed Program
This dissertation is a collection of statistical tools developed to create genetic relationship matrices for genome-wide association studies, and their application to epidemiological studies of sleep duration in the NHLBI TOPMed program. In chapter one, we proposed a Bayesian method to estimate inbreeding and kinship coefficients, thereby creating a novel Bayesian genetic relationship matrix. In…
Evaluation of the Safer Use of Antipsychotics in Youth (SUAY) Study on Population Level Antipsychotic Initiation: An Interrupted Time Series Analysis
Background: Atypical antipsychotics carry a high risk profile and may be prescribed for youth with conditions where other first line treatments are more appropriate. This study aimed to evaluate the population-level effectiveness of the Safer Use of Antipsychotics in Youth (SUAY) intervention, which aimed to reduce inappropriate atypical antipsychotic prescribing. Methods: We conducted an interrupted…
Methylation markers for anal cancer screening: a repeated cross-sectional analysis of HIV-positive individuals, 2015-2016
Background: HIV-positive individuals remain at risk for anal cancer and will likely benefit from research that prioritizes early detection of anal cancer and optimized screening practices. We assessed host deoxyribonucleic acid (DNA) methylation markers for detecting high-grade anal intraepithelial neoplasia (AIN) versus low-grade AIN or normal samples in HIV-positive individuals in Seattle, Washington. Methods: HIV-positive…
The Role of Maternal Height in Pregnancy Outcomes and Complications
Background: Adult height reflects not only an individual’s genetic make-up but also their early life environmental exposures, socioeconomic status, infectious disease history, nutrition, and growth and development. Increasing evidence suggests an inverse association of height with the risk of type 2 diabetes and cardiovascular disease among men and non-pregnant women. Studies of the association of…
The Association Between Experiencing Racism and Postpartum Care: A Cross-Sectional Study of Pregnant People in the United States in 2019
Background: The United States is the only high-income country with consistently high maternal mortality (MM) and severe maternal morbidity (SMM) rates, with Black pregnant people being disproportionately impacted. Racial and ethnic disparities in MM and SMM are not completely explained by social, economic, and behavioral factors suggesting that the impact of racism should be further…
The association between periconceptional diet quality and adverse pregnancy outcomes
Background: Diet quality during the periconceptional period can have consequences on pregnancy outcomes with potential life course implications for the pregnant person and the offspring. The Healthy Eating Index (total score) has been related to risk of adverse pregnancy outcomes. Little research has been done, however, evaluating associations of each component of the score with…
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