Graduate
May 20, 2022
Evaluation of Cognitive Function in the Dog Aging Project: Associations with Baseline Canine Characteristics
Background Canine Cognitive Dysfunction (CCD) is a neurodegenerative disease in aging canines. It has been described previously in relatively small cohorts of dogs using multiple different rating scales. This study aimed to use a minimally modified CCD rating scale developed by previous researchers to describe the prevalence of CCD more thoroughly in a large, nationwide…
Migraine and the risk of different molecular subtypes of breast cancer
Survivors of hematopoietic cell transplant (HCT) are at risk for neurocognitive impairments, which can impact quality of life. Given limited long-term studies, we aimed to characterize the late neurocognitive outcomes in a cohort of adult HCT survivors. Eligible survivors (age ≥21y at time of HCT and alive ³2y followed HCT) completed a 60-question survey of…
Long-term Neurocognitive Outcomes in Adult Survivors of Hematopoietic Cell Transplant
Survivors of hematopoietic cell transplant (HCT) are at risk for neurocognitive impairments, which can impact quality of life. Given limited long-term studies, we aimed to characterize the late neurocognitive outcomes in a cohort of adult HCT survivors. Eligible survivors (age ≥21y at time of HCT and alive ³2y followed HCT) completed a 60-question survey of…
Prevalence, incidence and characteristics associated with asymptomatic urethral inflammation in men who have sex with women
Background: Despite the potential to increase risk for acquisition of HIV and other sexually transmitted pathogens, the frequency with which men experience asymptomatic urethral inflammation is unknown. To better understand the full spectrum of perturbations to the male urethra, we aimed to determine the prevalence, incidence, and risk factors for asymptomatic urethral inflammation in men…
Invasive Mechanical Ventilation and Nutrition Intake in Association with Serious Outcomes among COVID-19 ICU Patients
Background: Worse clinical outcomes have been reported among critically ill COVID-19 patients who are admitted to an inpatient intensive care unit (ICU), especially those who require invasive mechanical ventilation (IMV). Patients on IMV do not receive any food or medication by mouth, during which their energy and protein needs are dependent on enteral nutrition (EN)…
Associations between isoniazid preventive therapy, non-tuberculous mycobacterial infection, and incipient TB signatures in people with HIV
Objective(s): To examine the association between isoniazid preventive therapy and incipient tuberculosis (TB) transcriptome-based signatures in persons with HIV (PWH) and to describe the association between non-tuberculous mycobacteria (NTM) and incipient TB signatures in PWH. Design: Cross-sectional study using clinical information and specimens obtained at one visit from previous cohort. Methods: Participants ages 18 to…
COVID-19 and Sexual and Reproductive Health Services in King County, Washington
Background: Lack of continuous access to high-quality sexual and reproductive health (SRH) services endangers individual- and population-level health. Understanding how the COVID-19 pandemic impacted SRH services will inform public health practices that guarantee access to SRH resources during times of future pandemics. The objective of this study was to investigate SRH prior to and during…
Impact of approval of biologic disease modifying anti-rheumatic drugs on juvenile idiopathic arthritis outcomes
Introduction: Juvenile idiopathic arthritis (JIA) affects nearly 300,000 US children, causing pain and physical disability. In clinical trials, biologic disease modifying antirheumatic drugs (bDMARDs) have been shown to decrease disease activity. We examined the effects of increased use of bDMARDs in realworld settings.Methods: We conducted a retrospective cohort study to assess outcomes in two cohorts…
Evaluating PrEP use and safety among women of reproductive age in sub-Saharan Africa
In sub-Saharan Africa, oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) has emerged as an important HIV prevention strategy for women and is being scaled up rapidly in areas with high HIV burden. New, long-acting PrEP methods are also approaching introduction, including the dapivirine vaginal ring, which women can wear continuously and…
The Impact of COVID-19 Stress on ART Adherence and Unsuppressed Viral Loads in People Living with HIV in Western Washington
Background: While current research finds that people living with HIV (PLWH) with suppressed HIV viral loads have similar likelihood of hospitalization and death due to COVID19 as the general population, COVID-19 stress may lead to decreased ability for PLWH to engage in care. Personal buffers, such as social support and identity characteristics, including US citizenship…
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