School of Public Health


EPI 519 Research Methods And Current Topics In Cardiovascular Epidemiology (3)

Overview of epidemiologic research methods applied to current topics in cardiovascular and cardiometabolic health and disease in human populations. Covers pathophysiology; molecular, clinical, behavioral, and social risk factors; burden and disparities across and within populations nationally and globally; and public health interventions. Prerequisite: EPI 511 or EPI 512; BIOST 508, BIOST 511 or BIOST 517; or permission Credit/no-credit only.

Winter 2021

Line Number Section ID Credits Days/Times Room/Bldg Instructor
14589A3.0Tuesday, Thursday @ 8:30am - 9:50amN/ANicholas L. Smith
For a complete listing of Epidemiology courses, their elective categories, and when they are typically offered, please see the Epidemiology Course Planning Sheet

Additional Course Details

The objective of the course is to provide graduate students with an overview of the current topics and methods in cardiovascular and cardiometabolic epidemiology.

Topics Covered

  • Hallmark cardiovascular outcomes and their risk factors including:
    • Myocardial infarction
    • Ischemic and hemorrhagic stroke
    • Venous thromboembolism
    • Atrial fibrillation
    • Sudden cardiac arrest
    • Heart failure
  • Genetics of CVD
  • Microbiome, inflammation, and CVD risk
  • Viremia and HIV and CVD risk
  • Lipids and sphingolipids and CVD risk
  • Diabetes and renal contributions to CVD risk
  • Global burden of CVD
  • Social determinants of CV health and disease
  • Community-based interventions in American Indians and in international settings
  • CVD and risk drug treatment and safety
  • Methods covered include:
    • Mendelian randomization
    • Genome-wide association studies
    • Causal inference
    • Multilevel analyses
    • Marginal structural models
    • Ascertainment methods

Learning Objectives

  • Appreciate the burden and impact of cardiovascular disease on the health of human populations;
  • Understand the breadth of common cardiovascular conditions and their inter-relationship to human biology and health;
  • Characterize the breadth of factors (causal and markers) from the human condition that modify cardiovascular and cardiometabolic health over the course of life;
  • Understand the role of public health agencies and interventions in shaping population cardiovascular health;
  • Characterize the strength and weakness of the current approaches to understanding and improving cardiovascular health in human populations.
  • Understand the application of current epidemiologic methods to improve our understanding of cardiovascular disease and health

Course Format

This 3-unit credit/no-credit lecture and discussion course.

How You Are Evaluated

Credit based on journal critiques and presentation.

Contact the Instructor

Nicholas L. Smith (