Faculty

Nicholas Smith

Professor, Epidemiology

206-221-1279

Education

PhD Epidemiology, University of Washington, 1997
MPH Epidemiology/Biostatistics, University of California (Berkeley), 1993
BA Social Sciences, University of California (Irvine), 1987

Contact

206-221-1279

Box 351619
Department of Epidemiology
Hans Rosling Center for Population Health, 886
Seattle, WA 98195
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Bio

Dr. Smith is Professor of Epidemiology and Director of the VA Seattle Epidemiologic Research and Information Center (ERIC) at the VA Puget Sound Health Care System

Research Areas

Research Interests

My research interests within cardiovascular epidemiologic research are wide and include investigations of inherited and acquired risk factors for arterial and venous thrombosis, diabetes, and heart failure. A major focus of my research in the past 15 years has been on genetic association studies, first conducted in the local setting and now being orchestrated internationally. Early work was conducted at Group Health Research Institute and involved a series of case-controls studies conducted with colleagues at the University of Washington. These studies addressed primarily pharmaco and pharmaco-genetic epidemiologic questions related to myocardial infarctions, stroke, and venous thrombosis. More recently, I have been involved in 2 large international genetics consortia, the Cohorts of Heart and Aging Genetic Epidemiology (CHARGE) Consortium and the International Network of Venous Thrombosis (INVENT) Consortium. In CHARGE, I co-convene 2 working groups, the CHARGE Hemostasis Working Group and the CHARGE Heart Failure Working Group. I am also a co-convener of the International Network on Venous Thrombosis (INVENT) consortium. For these consortia, I provide leadership in the conduct of intermediate and clinical phenotype association studies using genome-wide and exome-wide markers and exome sequencing. I am also the director of the Seattle Epidemiologic Research and Information Center (ERIC), a program of the Department of Veterans Affairs (VA) Cooperative Studies Program (CSP). The VA CSP is intimately involved in the VA’s Million Veteran Program (MVP), which is collecting DNA, lifestyle questionnaires from over a 1,000,000 Veterans who use the Veterans Health Administration for their care.

Recent Publications (PubMed)

Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.
(2025 Jun 24)
Blood Adv
Wolford BN, Zhao QY, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton BM, Desch KC, Thibord F, Klarin D, Johnson AD, Tregouet DA, Damrauer SM, Smith NL, Lo Faro V, Tsuo K, Daly M, Neale B, Zhou W, Willer CJ, Shavit JA, Surakka I
Epidemiology, Immunology and Clinical Characteristics of COVID-19 (EPIC(3))-Database of a prospective longitudinal observational study within the Veterans Health Administration.
(2025)
Front Public Health 13(): 1535315
Huang L, Li X, Kamal SI, Sugimoto JD, Liu CH, Wang T, Morelli DK, Midthun JB, Pakanati VR, Deardorff KV, Sporleder JL, Lopez J, Holodniy M, Smith NL, Lee JS, Shah JA, Ross JM
Functioning and disability consequences of comorbid posttraumatic stress disorder and diabetes in Vietnam era men and women veterans.
(2025 Jun 12)
Health Psychol
Serier KN, Burns HM, Magruder KM, Spiro A, Pless Kaiser A, Kimerling R, Frayne SM, Kilbourne AM, Stock EM, Forsberg CW, Smith NL, Smith BN
Evaluation of interfacility transfer patterns among patients with emergency general surgery conditions.
(2025 Jun 4)
Surgery 184(): 109448
Clark NM, Maine RG, Hantouli MN, Cooper E, Porter A, Sitlani CM, Smith NL, Davidson GH
Plasminogen activation and plasmin activity are not required to prevent venous thrombosis/thromboembolism.
(2025 May 22)
Blood
Sang Y, Menegatti M, Brody JA, Wiggins KL, Cooley BC, Kapfer KN, Kangro K, de Laat B, Peyvandi F, Flick MJ, Smith NL, Shapiro AD, Wolberg AS
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