Faculty

Holly R Harris

Affiliate Associate Professor, Epidemiology

206-667-2712

Education

ScD Harvard T.H. Chan,
MPH University of Southern California, 2005
BA Macalester College, 2000

Contact

206-667-2712

Fred Hutch Cancer Center
Box M4-B859
Program in Epidemiology, Division of Public Health Sciences
1100 Fairview Avenue North
Seattle, WA 98109

Research Interests

I am broadly interested in the impact of lifestyle, nutrition, and genetic factors on women’s health. Specifically, I have focused on ovarian and breast cancer, as well as on hormonally related conditions that have shared reproductive risk factors with these diseases, including endometriosis and uterine fibroids. Much of my research to date has focused on understanding the role of the potentially modifiable risk factors of diet and lifestyle on the risk of these conditions. A more recent facet of my research is to explore the interrelatedness of these conditions and their shared risk factors. As ovarian cancer is rare, I am particularly interested in identifying women, such as those with endometriosis, who may be at higher risk because these women may benefit from screening modalities for ovarian cancer which are currently not appropriate for population-based use. Identification of women at high risk for ovarian cancer and breast cancer is also important as it allows for targeted prevention strategies and can guide clinical decisions regarding frequency of screening and chemoprevention strategies for both of these cancers. Finally, understanding the influence of genetic factors, both alone or as a part of gene-environment interactions may facilitate prevention and help identify women most at risk for ovarian and breast cancer.

Recent Publications (PubMed)

Beyond BRCA deficiency: Clinical and molecular predictors of survival in patients with BRCA -deficient tubo-ovarian high-grade serous carcinoma.
(2025 Sep 22)
medRxiv
Zwimpfer TA, Fereday S, Pandey A, Ariyaratne D, Jayawardana MW, Twomey L, Laumont CM, Kennedy CJ, Bolithon A, Meagher NS, Milne K, Hamilton P, Alsop J, Antoniou AC, Au-Yeung G, Beckmann MW, Berrington de Gonzalez A, Bisinotto C, Blome F, Bodelon C, Boros J, Brand AH, Carney ME, Cazorla-Jiménez A, Chiu DS, Christie EL, Chudecka-Głaz A, Coulson P, Cushing-Haugen KL, Cybulski C, Darcy KM, David C, Davidson T, Ekici AB, Elishaev E, Emons J, Engler T, Farrell R, Fischer A, García-Closas M, Gentry-Maharaj A, Ghatage P, Glasspool R, Harter P, Hartkopf AD, Hartmann A, Heikaus S, Hernandez BY, Hettiaratchi A, Heublein S, Huntsman DG, Jimenez-Linan M, Jones ME, Kang E, Kaznowska E, Kluz T, Kommoss FKF, Konecny G, Kruitwagen RFPM, Kwon J, Lambrechts D, Lee CH, Lester J, Leung SCY, Leung Y, Linder A, Lissowska J, Loverix L, Lubiński J, Mateoiu C, McNeish IA, Moubarak M, Nelson GS, Nevins N, Olawaiye AB, Olbrecht S, Orsulic S, Osorio A, Quinn CM, Raj Mohan G, Ray-Coquard I, Rodríguez-Antona C, Roxburgh P, Ruebner M, Salfinger SG, Samra S, Schoemaker MJ, Sinn HP, Sonke GS, Steele L, Stewart CJR, Talhouk A, Tan A, Tarney CM, Taylor SE, Van de Vijver KK, van der Aa MA, Van Gorp T, Van Nieuwenhuysen E, van-Wagensveld L, Wahner-Hendrickson AE, Walter C, Wang C, Welz J, Wentzensen N, Wilkens LR, Winham SJ, Winterhoff B, Anglesio MS, Berchuck A, Candido Dos Reis FJ, Cohen PA, Conrads TP, Crowe P, Doherty JA, Fasching PA, Fortner RT, García MJ, Gayther SA, Goodman MT, Gronwald J, Harris HR, Heitz F, Horlings HM, Karlan BY, Kelemen LE, Maxwell GL, Menon U, Modugno F, Neuhausen SL, Schildkraut JM, Staebler A, Sundfeldt K, Swerdlow AJ, Vergote I, Wu AH, Brenton JD, Pharoah PDP, Pearce CL, Pike MC, Goode EL, Ramus SJ, Köbel M, Nelson BH, DeFazio A, Friedlander ML, Bowtell DDL, Garsed DW

Childhood and adolescent dietary patterns and incidence of benign breast disease.
(2025 Oct 2)
Cancer Causes Control
Garzia NA, Fest S, Cushing-Haugen K, Kensler TW, Chavarro JE, Tamimi RM, Harris HR

Regular physical inactivity and ovarian cancer risk in the Ovarian Cancer in Women of African Ancestry (OCWAA) Consortium.
(2025 Sep 16)
Cancer Epidemiol Biomarkers Prev
Lima SM, Minlikeeva AN, Johnson CE, Guertin KA, Bandera EV, Zheng W, Bethea TN, Petrick JL, Joslin CE, Myers ER, Harris HR, Peres LC, Setiawan VW, Wu AH, Rosenberg L, Schildkraut JM, Ochs-Balcom HM

Laparoscopically confirmed endometriosis and midlife plasma markers of inflammation, cholesterol, and adipokines among participants in the Nurses' Health Study II.
(2025 Sep)
Maturitas 200(): 108663
Farland LV, Degnan WJ 3rd, Harris HR, Sasamoto N, Rexrode KM, Missmer SA

GWAS meta-analysis identifies five susceptibility loci for endometrial cancer.
(2025 Aug)
EBioMedicine 118(): 105830
Ramachandran D, Wang X, Laisk T, Zheng Y, Ingold N, Canson DM, Kho PF, Naumann BJ, Chapman CJ, Bousset K, Krause AV, Schürmann P, Wieland B, Hanel P, Hülse F, Häfner N, Runnebaum I, Dubrowinskaja N, Turmanov N, Yugay T, Yessimsiitova ZB, Amant F, Annibali D, Beckmann MW, Bodelon C, Buchanan DD, Chen C, Clarke MA, Cook LS, De Vivo I, De Wispelaere W, Du M, Easton DF, Emons J, Fasching PA, Friedenreich CM, Gallagher G, Giles GG, Goode EL, Harris HR, Hunter DJ, Kolin DL, Kraft P, Lacey JV, Lambrechts D, Lu L, Mutter GL, Naduparambil J, O'Connell K, Patel AV, Pharoah PDP, Rebbeck TR, Ricceri F, Risch HA, Ruebner M, Sacerdote C, Scott RJ, Setiawan VW, Shu XO, Southey MC, Tham E, Tomlinson I, Turman C, Wentzensen N, Xu W, Yu H, Zheng W, Spurdle AB, Yarden Y, Estonian Biobank Research Team, Mägi R, Hillemanns P, Glubb DM, Dörk T, O'Mara TA

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