School of Public Health

McClelland, Scott

Scott McClelland

Professor, Medicine - Allergy and Infectious Dis.
Professor, Epidemiology
Professor, Global Health


MD Medicine, University of Washington, 1995
MPH Epidemiology, University of Washington, 2001
BS Biology, University of Washington, 1989

Contact Info

University of Washington
Box 359909
325 9th Avenue
Seattle, WA 98104
Tel: 206-543-4278

Dr. McClelland is an Associate Professor of Epidemiology, Medicine, and Global Health. He is co-Director of the University of Washington's Center for AIDS Research (CFAR) International Core, and a member of the International AIDS Research and Training Program and the Kenya Research Program faculty. Dr. McClelland is Site Leader for the University of Washington (UW)/University of Nairobi (UON) Mombasa HIV/STD Research Site. This highly productive research field site includes strong collaborative research efforts between the UW, UON, the Kenya Medical Research Institute (KEMRI), Coast Provincial General Hospital, the Municipal Council of Mombasa, and the Kenya Ministry of Health.


  • Impact of peri-conceptual vaginal microbiota on the risk of spontaneous preterm birth

  • RCT of an IS approach to improve the rate of HIV testing in women presenting for family planning in Mombasa County, Kenya

  • Effect of antiretroviral therapy on infectivity and sexual risk behavior in Kenyan women

  • Prevalence, correlates, and clinical outcomes of HIV-1/HBV co-infected women receiving antiretroviral therapy

  • Polymorphisms in the CYP2B6 drug metabolizing enzymes, clinical outcomes, and adverse drug events in antiretroviral treated Kenyan women

  • Incidence and epidemiologic correlates of HIV-1 superinfection

  • Vaginal ecology and the risk of HIV-1 and STIs in women
  • Randomized trial of periodic presumptive treatment to reduce vaginal infections in women at risk for HIV-1 and STIs
  • Women's Lifecourse Events and HIV Transmission Potential: A Multidisciplinary Study


Division of Infectious Diseases:

Department of Global Health:

Center for AIDS Research:

Kenya Research Program:

Mombasa Field Site:

Research Interests

Dr. McClelland's research focuses on human immunodeficiency virus (HIV) and sexually transmitted infection (STI) epidemiology and prevention in most at-risk populations including female sex workers and men who have sex with men. This includes both primary prevention strategies for reducing the risk of HIV/STI acquisition and secondary prevention aimed at reducing infectiousness and risk behavior in people living with these conditions.

Dr. McClelland is the Protocol Chair for a Sexually Transmitted Infections Clinical Trials Group funded study entitled, "Preventing Vaginal Infections (PVI Trial)." This double-blind, randomized trial is evaluating the efficacy of monthly treatment with topical metronidazole and fluconazole co-formulated suppositories versus placebo for preventing vaginal infections in HIV-1-seronegative women. Vaginal infections have been associated with increased risk for HIV-1 acquisition, and may account for a high population attributable risk of HIV-1 infection. The PVI trial is ongoing, and includes sites in Mombasa and Nairobi, Kenya as well as Birmingham, Alabama.

Dr. McClelland is the study leader for an NIH/NICHD-funded P01 study that is part of a program-project grant entitled "Mechanisms and Cofactors for HIV-1 Transmission in Women."Dr. McClelland's project, entitled "Vaginal Flora and HIV-1 Acquisition in Women" involves a multi-site case-control study to compare vaginal bacterial flora using molecular methods in HIV-1 seroconverters compared to controls who remain HIV-1 seronegative. Participants include the high-risk cohort in Mombasa and a cohort of pregnant and post-partum women in Kisumu, Kenya.This study is ongoing.

Teaching Interests

Dr. McClelland teaches Epidemiology 532, "Epidemiology of Infectious Diseases in Resource-Limited Countries." The course is offered every other year (odd number years) in the Spring. He is a regular lecturer in med 561 (Tropical Medicine), EPI 507/OBGYN590 (HIV and STDs in Women and Children), EPI 530 (AIDS, A Multidisciplinary Approach), and GH573 (Clinical Management of HIV).



In The News

Uncovering the female body’s secret protection against HIV
PBS NewsHour, 08/19/2016