Faculty

Nona Sotoodehnia

Adjunct Professor, Epidemiology
Professor, Medicine - Cardiology
Co-Director, Cardiovascular Health Research Unit, Medicine - Cardiology
John Laughlin Endowed Professorship in Cardiovascular Research, Medicine - Cardiology

206-287-2777

Education

MPH Harvard School of Public Health, 1996
MD Harvard Medical School, 1996
BS Massachusetts Institute of Technology, 1991

Contact

206-287-2777

Box 359748
WA

Bio

Dr. Sotoodehnia, the John and Cookie Laughlin Endowed Professor in Cardiology, is co-director of the Cardiovascular Health Research Unit. She is a general cardiologist at Harborview Medical Center.

She conducts research on the genomics and epidemiology of cardiovascular diseases and risk factors. Her research focus includes cardiac arrhythmias and sudden cardiac arrest, diabetes and coronary heart disease. She and her group are leading efforts in precision medicine, examining drug-gene interactions, risk prediction and drug safety. Her work investigates gender and ethnic differences in cardiovascular risk and outcomes. In addition, she has a long interest in international health and is helping lead efforts in cardiovascular treatments in Nepal.

Research Interests

  • Preventive cardiology
  • Arrhythmias including sudden cardiac death and atrial fibrillation
  • Coronary heart disease
  • Precision medicine
  • International health
  • Diabetes and gender 
  • Ethnic differences in cardiovascular risk and outcomes

Recent Publications (PubMed)

cpiVAE: Robust and Interpretable Cross-Platform Proteomics Imputation.
(2025 Nov 21)
bioRxiv
Li Y, Duong T, Rooney MR, Ballantyne CM, Coresh J, Brody JA, Sotoodehnia N, Arking DE, Bader JS

Deciphering the Role of Different Ceramide Synthases in the Human Cardiomyocyte Hypertrophic Response.
(2025 Sep 22)
Metabolites 15(9):
Wiley AM, Krueger MA, Sotoodehnia N, Umans JG, Hoofnagle AN, Lemaitre RN, Totah RA, Gharib SA

Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis.
(2025 Aug 31)
Metabolites 15(9):
Wiley AM, Krueger MA, Becker JO, Karasu M, Sotoodehnia N, Umans JG, Hoofnagle AN, Gharib SA, Totah RA, Lemaitre RN

Associations of Plasma Trimethylamine N -Oxide-Related Metabolites with the Development and Progression of Albuminuria : The Multiethnic Study of Atherosclerosis.
(2025 Nov 1)
Clin J Am Soc Nephrol 20(11): 1549-1563
Wang M, Tang WHW, Li XS, de Oliveira Otto MC, Lemaitre RN, Fretts A, Nemet I, Sotoodehnia N, Sitlani CM, Budoff M, DiDonato JA, Wang Z, Siscovick DS, Sarnak MJ, Mozaffarian D, Hazen SL

Premature Ventricular Contraction Location and Incident Heart Failure.
(2025 Sep 11)
JACC Clin Electrophysiol
Dewland TA, Rosenthal DG, Gerstenfeld EP, Scheinman MM, Alonso A, Soliman EZ, Chen LY, Siscovick DS, Sotoodehnia N, Gottdiener JS, Psaty BM, Heckbert SR, Stein PK, Marcus GM

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