Co-occurring clonal hematopoiesis exhibits strong selection and high leukemia risk.
(2026 May 21)
Nat Commun
Barnao KM, Hubbard AK, Chan ICC, Zhou W, Jakubek YA, Genovese G, Wong WSW, Kelly RL, Young CD, Brown DW, Huang WY, Freedman ND, Jones K, Hutchinson A, Hicks B, Tran D, Arnett D, Barnes KC, Bis JC, Boerwinkle E, Brody JA, Carson AP, Chasman DI, Cho MH, Desai P, Doyle MF, Fornage M, Guo X, Heard-Costa N, Irvin MR, Johnson AD, Kardia SLR, Kooperberg C, Levy D, Lewis JP, Li Y, Loos RJF, Mack TM, Mathias RA, Mitchell BD, North KE, Pankratz N, Peyser PA, Preuss MH, Psaty BM, Raffield LM, Redline S, Rich SS, Rotter JI, Silverman EK, Smith AV, Smith JA, Stilp A, Cao Y, Scheet P, Reiner AP, Bick AG, Chanock SJ, Auer PL, Bolton KL, Machiela MJ

Rare coding variant architecture and gene discovery from 130,000 sequenced cases of atrial fibrillation.
(2026 May 4)
Res Sq
Jurgens S, Enzan N, Dinsmore I, Choi SH, Luo J, Lipov A, Hartle C, Wang X, Marston N, Weng LC, Melloni G, Chalazan B, Gray M, Pirruccello J, Diaz A, Chaffin M, Ornelas-Loredo A, Tang O, Darbar F, Kany S, Chen Y, von Falkenhausen A, Morrison A, Natale A, Tveit A, Geelhoed B, Cade B, Wagoner DV, Haase D, Soliman EZ, Davogustto G, Calkins H, Anderson J, Brody J, Barnard J, Hokanson J, Smith J, Bis J, Young K, Johnson L, Long L, Risch L, Gula L, Kwee L, Kühne M, Preuss M, Gupta N, Nafissi N, Smith N, Nilsson P, van der Harst P, Wells Q, Judy R, Schnabel R, Johnson R, Smit RAJ, Gabriel S, Knight S, Furukawa T, Min YI, Yoneda Z, Laksman Z, Alonso A, Psaty B, Albert C, Arking D, Roden D, Chasman D, Rader D, Conen D, McManus D, Fatkin D, Boerwinkle E, Marcus G, Christophersen I, Smith JG, Roberts J, Raffield L, Shoemaker MB, Cho M, Cutler M, Chung M, Olesen M, Sinner M, Sotoodehnia N, Kirchhof P, Loos RJF, Nazarian S, Mohanty S, Damrauer S, Kaab S, Heckbert S, Redline S, Shah S, Tanaka T, Ebana Y, Lubitz S, Lunetta K, Benjamin E, Rienstra M, Figtree G, Darbar D, Bezzina C, Ruff C, Sabatine M, Mirshahi T, Ellinor P

Machine learning cross-platform proteomic imputation enables protein quality scoring and replication of epidemiological associations.
(2026 May 9)
bioRxiv
Li L, Alaa A, Tan Y, Demirel I, Friedman S, Zha Q, Tracy R, Taylor KD, Yu B, Ballantyne CM, Deo R, Dubin R, Tsai MY, Peloso GM, Brody J, Austin T, Psaty BM, Nicholas J, Raffield LM, Tahir U, Coresh J, Hornsby W, Chan A, Rich SS, Rotter JI, Ganz P, Gerszten R, Philippakis A, Natarajan P, Yu Z

Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals.
(2026 May 5)
Nat Med
Neuen BL, Major RW, Grams ME, Sang Y, Coresh J, Ballew SH, Surapaneni A, de Pinho NA, Arnlov J, Arnott C, Bell S, Berry J, Brenner H, Ciemins E, Chang AR, Cushman M, de Lemos JA, Diaz-Tocados JM, Farjat AE, Fletcher RA, Gansevoort RT, Heerspink HJL, Herrington WG, Hong C, Horwitz EJ, Hwang SJ, Jassal SK, Kalra PA, Katz R, Khan SS, Kovesdy CP, Kronenberg F, Lees JS, Lloyd-Jones DM, Mill JG, Naimark DMJ, Ndumele C, Polkinghorne KR, Psaty BM, Schloemer P, Shlipak M, Shrestha P, Song Z, Staplin N, Steubl D, Vart P, Visseren FLJ, Woodward M, Yamagishi K, Young BA, Sabanayagam C, Valdivielso JM

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging.
(2026 Mar 19)
Am J Respir Crit Care Med
Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O'Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan R, Oelsner EC, Manichaikul A, Bick AG, Scheet P, Reiner AP, NHLBI Trans-Omics for Precision Medicine Consortium, Jakubek YA, Auer PL, Cho MH, DeMeo DL