MS
November 18, 2020
Unnecessary inhaled corticosteroids in COPD: understanding patient and health system complexity as contributors
OBJECTIVE To determine if patient complexity is associated with unnecessary use of inhaled corticosteroids (ICS) among patients with chronic obstructive pulmonary disease (COPD) at low risk of exacerbations and if health system complexity modifies this association. METHODS We identified Veterans with COPD without a guideline-recommended indication for ICS from electronic health records between January 2012…
Elevated vaginal pH levels and HPV among Senegalese women
Our investigation aimed to explore the extent to which elevated vaginal pH is associated with prevalent HPV infection among a cohort of Senegalese women ages 18-84. Sub-Saharan Africa has the greatest global burden of vaginal dysbiosis and the highest prevalence of HPV infection among women (24%). Globally, Africa has the highest estimated age-standardized cervical cancer…
Trajectories of Suicide Mortality in US Counties from 2000-2017 and the Influence of Selective Migration
Objectives: To identify five distinct latent trajectory classes of suicide mortality among US Counties from 2000 to 2017 and to compare these trajectories to each county’s cumulative net migration over the study period to assess the influence of population change due to migration as a potential measure of economic opportunity. Methods: The annual county suicide…
Effects of Washington’s opioid prescribing rules for chronic, non-cancer pain management on opioid overdose mortality and pharmaceutical opioid distribution: 1999-2017
Background Since the 1990s, the opioid crisis has affected individuals and communities across the United States. National and statewide comprehensive efforts to address the problem include policies to prevent opioid addiction, identify opioid-addicted individuals, and provide effective treatment. In Washington state, in response to rising prescription opioid-related overdose deaths, the legislature passed the Engrossed Substitute…
Plasma Amyloid, Inflammatory Markers, and Risk of Dementia in the Ginkgo Evaluation of Memory Study
Most individuals with dementia have mixed neurodegenerative and vascular pathologies that may interact to accelerate cognitive decline. Prior studies have shown that two vascular inflammatory markers (pentraxin 3 and serum amyloid P) and plasma amyloid are associated with dementia, though results have been inconsistent. Using weighted Cox proportional hazards regression, we evaluated the joint associations…
Eplet mismatches and de novo donor-specific antibody development in pediatric kidney transplant recipients
Background: The presence of HLA de novo donor-specific antibodies (dnDSA) is associated, probably causally, with failure of kidney transplants. In a pediatric kidney transplant population, we sought to determine the extent to which eplet mismatches (MM) are associated with the development of dnDSA. Methods: We performed a retrospective cohort analysis of pediatric kidney transplant recipients…
Non-inferiority of a non-contrast MRI follow up protocol for isolated optic pathway gliomas
BACKGROUND Pediatric optic pathway gliomas (OPGs) are typically indolent, but have variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced magnetic resonance (CEMR) examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents (GBCAs). OBJECTIVES 1) Determine surveillance MR factors that motivate changes in tumor-directed therapies (TDTs), establish GBCA…
Risk Factors for Severe Acute Kidney Injury after Pediatric Hematopoietic Stem Cell Transplantation
Background: Acute Kidney Injury (AKI) is common after Hematopoietic Stem Cell Transplantation (HSCT) and is associated with increased morbidity and mortality. Risk factors for AKI after HSCT are not fully understood, and there are limited pediatric studies that describe post HSCT AKI. Objective: To assess unique risk factors for AKI in the HSCT population. Design/Methods:…
Genetic variation in telomere maintenance genes and survival after colorectal cancer diagnosis
INTRODUCTION Telomeres are the repetitive nucleotide sequences capping the end of chromosomes and are regulated by telomerase. Both telomere length and telomerase initiate carcinogenesis and prognosis in patients diagnosed with cancer, including colorectal cancer (CRC). Genome-wide association studies (GWAS) have identified several loci related to telomere length or telomerase activity, but the association between those…
Hospital Resource Utilization and Presence of Advance Directives at the End of Life for Adults with Congenital Heart Disease
OBJECTIVE Overall healthcare resource utilization by adults with congenital heart disease has increased dramatically in the last two decades. No prior studies have examined utilization at the end of life. The objective of this study is to better understand the patterns and influences on the intensity of care at the end of life for adults…
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