MS
November 18, 2020
Plasma Amyloid, Inflammatory Markers, and Risk of Dementia in the Ginkgo Evaluation of Memory Study
Most individuals with dementia have mixed neurodegenerative and vascular pathologies that may interact to accelerate cognitive decline. Prior studies have shown that two vascular inflammatory markers (pentraxin 3 and serum amyloid P) and plasma amyloid are associated with dementia, though results have been inconsistent. Using weighted Cox proportional hazards regression, we evaluated the joint associations…
Eplet mismatches and de novo donor-specific antibody development in pediatric kidney transplant recipients
Background: The presence of HLA de novo donor-specific antibodies (dnDSA) is associated, probably causally, with failure of kidney transplants. In a pediatric kidney transplant population, we sought to determine the extent to which eplet mismatches (MM) are associated with the development of dnDSA. Methods: We performed a retrospective cohort analysis of pediatric kidney transplant recipients…
Non-inferiority of a non-contrast MRI follow up protocol for isolated optic pathway gliomas
BACKGROUND Pediatric optic pathway gliomas (OPGs) are typically indolent, but have variable clinical course. Treatment is dictated by symptoms and changes on contrast-enhanced magnetic resonance (CEMR) examinations. Gadolinium retention in children has motivated parsimonious use of gadolinium-based contrast agents (GBCAs). OBJECTIVES 1) Determine surveillance MR factors that motivate changes in tumor-directed therapies (TDTs), establish GBCA…
Risk Factors for Severe Acute Kidney Injury after Pediatric Hematopoietic Stem Cell Transplantation
Background: Acute Kidney Injury (AKI) is common after Hematopoietic Stem Cell Transplantation (HSCT) and is associated with increased morbidity and mortality. Risk factors for AKI after HSCT are not fully understood, and there are limited pediatric studies that describe post HSCT AKI. Objective: To assess unique risk factors for AKI in the HSCT population. Design/Methods:…
Genetic variation in telomere maintenance genes and survival after colorectal cancer diagnosis
INTRODUCTION Telomeres are the repetitive nucleotide sequences capping the end of chromosomes and are regulated by telomerase. Both telomere length and telomerase initiate carcinogenesis and prognosis in patients diagnosed with cancer, including colorectal cancer (CRC). Genome-wide association studies (GWAS) have identified several loci related to telomere length or telomerase activity, but the association between those…
Hospital Resource Utilization and Presence of Advance Directives at the End of Life for Adults with Congenital Heart Disease
OBJECTIVE Overall healthcare resource utilization by adults with congenital heart disease has increased dramatically in the last two decades. No prior studies have examined utilization at the end of life. The objective of this study is to better understand the patterns and influences on the intensity of care at the end of life for adults…
Transplant-Associated Thrombotic Microangiopathy (TA-TMA) is a Multifactorial Disease Unresponsive to Immunosuppressant Withdrawal
Background: Transplant-associated thrombotic microangiopathy (TA-TMA) after allogeneic hematopoietic cell transplantation (HCT) has not been well-characterized in large population studies with clinically adjudicated cases. Methods: We performed a retrospective cohort study of adults who underwent allogeneic HCT between 2006 and 2015 to determine the incidence of and risk factors for TA-TMA, and to describe its natural…
POLST-Discordant Intensive Care Near the End of Life: A Retrospective Cohort Study
Importance: Patients with chronic life-limiting illness frequently use the Physician Orders for Life Sustaining Treatment (POLST) to document preferences for limiting intensive care. However, the incidence and predictors of POLST-discordant care near the end of life are not known. Objective: To describe the incidence, predictors, and intensity of POLST-discordant intensive care among patients hospitalized near…
Health care service utilization of individuals in permanent supportive housing in Seattle, WA accessing care through Public Health – Seattle and King County’s Health Care for the Homeless Network
Introduction: Permanent supportive housing (PSH) programs combine non-time limited housing with optional supportive services, including case management and health care, and are designed for those facing barriers to housing stability. Prior studies suggest that PSH can reduce emergency room visits and health care expenditures for an individual while improving their housing stability and well-being. However,…
Racial/Ethnic Disparities in Risk of Breast Cancer Mortality by Molecular Subtype and Stage at Diagnosis
Previous research has found significant survival disparities between African-American and white women among select stages and subtypes of breast cancer, however other racial/ethnic groups have been less well-studied. This study expands on previous research, examining differences in breast cancer-specific mortality across multiple racial and ethnic groups. Women diagnosed with a first primary invasive breast cancer…
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