MS
November 19, 2020
Resolution of Sepsis-Associated Acute Kidney Injury: Association with Emergency Department Fluid Management Patterns
Background: Sepsis is the most common cause of acute kidney injury (AKI). AKI is associated with poor outcomes including progression to chronic kidney disease, increased intensive care unit and hospital length of stay, and mortality. Recent evidence suggests that trajectory of AKI (duration and resolution/persistence), rather than KDIGO stage, is associated with these poor outcomes….
November 18, 2020
Beta Lactam and Other Antibiotic Allergies in Solid Organ and Hematopoietic Cell Transplant Recipients
Background Patients with reported beta lactam antibiotic allergies (BLA) are more likely to receive broad-spectrum antibiotics and experience adverse outcomes. Data on the burden of beta lactam and other antibiotic allergies among solid organ transplant (SOT) and hematopoietic cell transplant (HCT) recipients are limited. Methods We reviewed records of first-time adult SOT or allogeneic HCT…
Outcomes of Wraparound Care Coordination for Youth with Complex Behavioral Health Needs
Background. Approximately 10% of youth in the US are estimated to experience “serious emotional disorder,” or SED. Wraparound is a commonly implemented care coordination process for youth with SED and complex needs, but effectiveness research is sparse, and results have been mixed. RCTs have found favorable effects of Wraparound on child welfare placements and service…
Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
In vitro testing of cholinesterase inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting pathologies associated with Alzheimer’s Disease. Imaging studies had inconsistent results. Our objective was to assess the impact…
Social Determinants of Asthma in American Indian Children
BACKGROUND American Indian (AI) / Alaska Native (AN) children have a higher asthma prevalence than white children in the U.S. (9.4% versus 7.7%, respectively). The AI/AN population is extremely diverse; demographic, lifestyle, genetic, and environmental factors influence asthma prevalence and severity in these communities. Our study sought to examine risk factors associated with asthma among…
Detection of protein targets associated with survival in malignant pediatric brain tumors
BACKGROUND Brain tumors are the leading cause of pediatric cancer death. Specific protein detection by immunohistochemistry may predict patient survival and identify opportunities for targeted therapy. The purpose of this study was to evaluate the prevalence of selected protein markers to prioritize targets for further therapeutic study. PROCEDURE We studied a single institution cohort of…
Unnecessary inhaled corticosteroids in COPD: understanding patient and health system complexity as contributors
OBJECTIVE To determine if patient complexity is associated with unnecessary use of inhaled corticosteroids (ICS) among patients with chronic obstructive pulmonary disease (COPD) at low risk of exacerbations and if health system complexity modifies this association. METHODS We identified Veterans with COPD without a guideline-recommended indication for ICS from electronic health records between January 2012…
Elevated vaginal pH levels and HPV among Senegalese women
Our investigation aimed to explore the extent to which elevated vaginal pH is associated with prevalent HPV infection among a cohort of Senegalese women ages 18-84. Sub-Saharan Africa has the greatest global burden of vaginal dysbiosis and the highest prevalence of HPV infection among women (24%). Globally, Africa has the highest estimated age-standardized cervical cancer…
Trajectories of Suicide Mortality in US Counties from 2000-2017 and the Influence of Selective Migration
Objectives: To identify five distinct latent trajectory classes of suicide mortality among US Counties from 2000 to 2017 and to compare these trajectories to each county’s cumulative net migration over the study period to assess the influence of population change due to migration as a potential measure of economic opportunity. Methods: The annual county suicide…
Effects of Washington’s opioid prescribing rules for chronic, non-cancer pain management on opioid overdose mortality and pharmaceutical opioid distribution: 1999-2017
Background Since the 1990s, the opioid crisis has affected individuals and communities across the United States. National and statewide comprehensive efforts to address the problem include policies to prevent opioid addiction, identify opioid-addicted individuals, and provide effective treatment. In Washington state, in response to rising prescription opioid-related overdose deaths, the legislature passed the Engrossed Substitute…
Previous page Next page