Graduate
January 12, 2021
Psychiatric diagnoses in children and adolescents with chronic kidney disease
Background: Children with chronic kidney disease (CKD) are subject to a myriad of complex physical and psychosocial challenges, which may confer increased risk of developing a psychiatric disorder when compared with the general population. Currently available studies are limited by small sample size, narrow geographic region, or inconsistent disease definitions. This study uses a large…
Weight gain following antiretroviral therapy (ART) initiation in ART-naive people living with HIV in the current treatment era
Objectives We evaluated weight change among people living with HIV (PLWH) initiating antiretroviral therapy (ART) in the current treatment era. Methods Between 2012-2019, in 8 Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites, we identified 3232 ART-naïve PLWH starting 3-drug ART, including efavirenz (EFV), rilpivirine (RPV), atazanavir (ATV), darunavir (DRV), raltegravir (RAL),…
Diet quality and depressive symptoms in a cohort of American Indians: The Strong Heart Family Study
Background: Higher diet quality has been shown to be associated with a lower risk of depression compared to lower diet quality, though this relationship has not been studied in American Indians (AIs). We examined the relationship of diet quality with incidence of depressive symptoms in a prospective, family-based cohort of 1,100 AIs ≥14 years of…
November 25, 2020
Firearm-related morbidity and mortality by injury intent: Analysis of medical, criminal, and vital records in Seattle, WA
BACKGROUND Due to the reliance on administrative records in firearm injury research, individual studies do not present an integrated picture of firearm injuries. Non-fatal and fatal injuries are frequently studied separately, as are injuries of different intents. Certain risk factors for assault-related firearm injuries, like characteristics of the neighborhoods where they occur, the injured person’s…
Cattle-associated risk factors for human tuberculosis in rural livestock keeping communities, Uganda
Tuberculosis (TB) is a leading infectious cause of human death worldwide. TB can also infect cattle, resulting in productivity losses, trade barriers, and zoonotic transmission via milk, meat, or direct contact. While the majority of TB cases are non-zoonotic, an unknown proportion are acquired from cattle; in Africa, this proportion is estimated to be 0.4%…
Effect modification of the alcohol – colorectal cancer association
INTRODUCTION Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a meta-analysis of 16 studies of CRC to examine the shape of the alcohol-CRC association, investigate potential effect…
Trends in incidence of vancomycin-resistant enterococcus colonization and bacteremia among hematopoietic cell transplant recipients at a large comprehensive cancer care center
BACKGROUND Vancomycin-resistant Enterococcus (VRE) are important hospital-acquired pathogens among hematopoietic cell transplant (HCT) recipients. We examined the incidence and outcomes of patients with VRE colonization and bacteremia (VREB) over a ten-year period at a center that routinely screens and uses barrier precautions for VRE. METHODS Adults receiving their first allogeneic HCT at our center between…
Effects of Intubation Location on Risk of Ventilator Associated Events
BACKGROUND Ventilation is a crucial tool in modern medicine that allows for advanced respiratory support in critically ill patients. However, prolonged ventilation has been found to be linked with ventilator-associated conditions (VACs), which in turn are associated with multiple adverse hospital outcomes. OBJECTIVES To evaluate the association between intubation practices (using intubation locations as a…
Incidence, Longitudinal Trajectory, and Hemodynamic Implications of Cardiac Dysfunction Following Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public heath problem and leading cause of death and disability worldwide. While hemodynamic instability is common following TBI and associated with increased mortality, few studies have evaluated the function of the heart following TBI. Understanding the role of cardiac dysfunction following TBI represents a major gap in the…
Stressful Life Events in Pregnancy and Postpartum Depressive Symptoms among Women in Washington State
BACKGROUND Stressful life events (SLEs) such as job loss or death of a loved one are common in pregnancy. Studies have shown that women with SLEs during pregnancy are more likely to develop postpartum depressive symptoms (PDS). This study examined the association between stressful life events (SLEs) experienced one year before delivery and postpartum depressive…
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