Graduate
August 12, 2025
A Nationwide Analysis of Financial Hardship After Surgery
Background and Objectives: Affordable access to surgical remains elusive for many in the US. However, the financial hardship attributable to surgery is not well understood at the national level. Our objectives were to (1) evaluate the association between surgery and financial hardship among working age adults in the US, (2) compare changes in financial hardship…
Ultra-processed foods, plant and animal source, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study
Background: Ultra processed food (UPF) consumption is associated with adverse health outcomes. Plant- and animal-sourced UPF have a unique nutritional composition to improve palatability which may impact health, but evidence is limited. The objective of this study aimed to investigate the association between UPF intake, plant-, and animal-sourced UPF, and mortality outcomes in older adults….
Elexacaftor/Tezacaftor/Ivacaftor Prescription in Lung Transplant Recipients with Cystic Fibrosis in the US
Elexacaftor/tezacaftor/ivacaftor (ETI) has dramatically improved pulmonary and extrapulmonary manifestations of cystic fibrosis (CF). ETI clinical trials excluded lung transplant (LTx) recipients, and current post-transplant prescribing practices are not evidence-based. We sought to identify the prevalence of new ETI prescriptions among CF LTx recipients in the United States (U.S.) and factors associated with ETI prescription after…
Factors associated with mortality and the need for re-intervention after stage 1 palliation for single ventricle heart disease
Background: Single ventricle management comprises a series of complex surgical procedures that are initiated during the newborn period. Despite advancements in surgical techniques, infants with a single ventricle face high mortality and the likelihood of unplanned reinterventions. Understanding the factors contributing to these reinterventions potentially could enhance patient outcomes, improve preoperative risk counseling to the…
Representation of Minoritized People with Cystic Fibrosis in CF Therapeutics Development Network Clinical Studies
Black and Hispanic people with CF (PwCF) experience a greater burden of worse health outcomes related to pulmonary disease compared to White, non-Hispanic PwCF. Prior evidence suggests that these communities are underrepresented in clinical research in CF. We used clinical study data from four recent modulator studies (CHEC-SC, PROMISE, PROSPECT, and GOAL) as well as…
Cytokines associated with moderate and severe adverse events during a controlled human malaria infection trial
Background: Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events (AEs) have not been examined.Methods: In order to determine which cytokines were associated with moderate and severe AEs, we measured the concentration of…
Metabolite-predicted biological age acceleration and associations with oncologic, neurodegenerative, and adiposity-related endpoints in multi-ancestry populations
Chronologic age is widely understood as a significant risk factor for many chronic diseases and is frequently used in risk stratification to guide selective screening. However, for age-related diseases, chronological age alone may not accurately reflect the underlying heterogeneity in biological aging that contributes to disease risk. Using prospectively collected data from the Women’s Health…
Optimizing the Placement of Automated External Defibrillators in Marin County, CA — A Location-Allocation Analysis
This study evaluated the spatial and temporal coverage of public automated external defibrillators (AEDs) in Marin County, California, from 2019 to 2024 to determine whether existing AEDs were optimally located to maximize Out-of-hospital cardiac arrest (OHCA) coverage and to identify additional placement opportunities. We defined coverage as the proportion of OHCAs occurring within 100 meters…
Factors Associated with Latent Tuberculosis Treatment Initiation for Primary Care Patients in a Large Health System
Background: One of the mainstays of eliminating tuberculosis as a public health threat is through the treatment of latent tuberculosis infections (LTBI). To determine ways to improve LTBI treatment rates, we assessed factors associated with LTBI treatment initiation in United States (US)-based primary care clinics. Methods: Using electronic health record data, we identified adult primary…
Pediatric Oncology and Bone Marrow Transplant ICU Patients in Children’s and General Hospitals
Pediatric oncology and hematopoietic stem cell (HCT) care in the US is increasingly provided at children’s hospitals (CH), but many children still receive care at general hospitals (GH). Little is known about the characteristics of pediatric oncology and HCT patients treated in intensive care units (ICUs) at these institutions, or how outcomes differ for patients…
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