Graduate
August 12, 2025
Representation of Minoritized People with Cystic Fibrosis in CF Therapeutics Development Network Clinical Studies
Black and Hispanic people with CF (PwCF) experience a greater burden of worse health outcomes related to pulmonary disease compared to White, non-Hispanic PwCF. Prior evidence suggests that these communities are underrepresented in clinical research in CF. We used clinical study data from four recent modulator studies (CHEC-SC, PROMISE, PROSPECT, and GOAL) as well as…
Cytokines associated with moderate and severe adverse events during a controlled human malaria infection trial
Background: Ensuring the safety and efficacy of candidate vaccines is critical. Although mechanisms underpinning protective immune responses to malaria vaccines are frequently investigated, immune responses correlating with moderate and severe adverse events (AEs) have not been examined.Methods: In order to determine which cytokines were associated with moderate and severe AEs, we measured the concentration of…
Metabolite-predicted biological age acceleration and associations with oncologic, neurodegenerative, and adiposity-related endpoints in multi-ancestry populations
Chronologic age is widely understood as a significant risk factor for many chronic diseases and is frequently used in risk stratification to guide selective screening. However, for age-related diseases, chronological age alone may not accurately reflect the underlying heterogeneity in biological aging that contributes to disease risk. Using prospectively collected data from the Women’s Health…
Optimizing the Placement of Automated External Defibrillators in Marin County, CA — A Location-Allocation Analysis
This study evaluated the spatial and temporal coverage of public automated external defibrillators (AEDs) in Marin County, California, from 2019 to 2024 to determine whether existing AEDs were optimally located to maximize Out-of-hospital cardiac arrest (OHCA) coverage and to identify additional placement opportunities. We defined coverage as the proportion of OHCAs occurring within 100 meters…
Factors Associated with Latent Tuberculosis Treatment Initiation for Primary Care Patients in a Large Health System
Background: One of the mainstays of eliminating tuberculosis as a public health threat is through the treatment of latent tuberculosis infections (LTBI). To determine ways to improve LTBI treatment rates, we assessed factors associated with LTBI treatment initiation in United States (US)-based primary care clinics. Methods: Using electronic health record data, we identified adult primary…
Pediatric Oncology and Bone Marrow Transplant ICU Patients in Children’s and General Hospitals
Pediatric oncology and hematopoietic stem cell (HCT) care in the US is increasingly provided at children’s hospitals (CH), but many children still receive care at general hospitals (GH). Little is known about the characteristics of pediatric oncology and HCT patients treated in intensive care units (ICUs) at these institutions, or how outcomes differ for patients…
Receipt of Glucagon-Like Peptide-1 Receptor Agonists Among rural Patients with Obstructive Sleep Apnea and Excess Weight
Successful weight loss is more difficult for those with OSA, and gaps in weight management care are more pronounced in rural areas. Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) are promising agents to improve the effectiveness of weight management care patients with OSA and excess weight living in rural areas. We sought to test the association of…
August 5, 2025
Advancing Sexual Health for Cisgender Women: A Series of Studies Addressing Doxycycline Post-Exposure Prophylaxis, Vaginal Health, and Antimicrobial Resistance in Kenyan Women
Abstract Globally, high rates of sexually transmitted infections (STIs) persist even in the face of effective antibiotic treatment, with young women living in Africa facing a disproportionate burden. Sexually transmitted infections can lead to dire reproductive health consequences for women, including severe complications and significant economic burdens related to lost productivity and quality of life….
Early Childhood Education and Violence Prevention Across the Life Course and Generations
Abstract High-quality early childhood education may buffer against social and structural drivers of interpersonal and self-directed violence. This dissertation examined associations of Head Start—a large-scale early childhood education program for low-income children, launched in 1965 as part of the War on Poverty—and violence-related outcomes within and across generations. Intragenerational analyses found that attending Head Start…
Retention, mental health, and scalable treatment programs for youth living with HIV: An exploration of social and behavioral influences
Abstract Background: Adolescents and young adults living with HIV (AYLHIV) are at higher risk of negative health outcomes including disengagement from care, viral non-suppression, depression, and anxiety. This additional risk may be partially explained by the substantial changes in relationship structures, cognitive functioning, and independent self-management of HIV that occur throughout adolescence, but age-specific data…
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